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Fournier gangrene

MedGen UID:
65967
•Concept ID:
C0238419
•
Disease or Syndrome
Synonyms: Fournier Disease; Fournier Gangrene; Fournier's Disease; Fournier's Gangrene; Fourniers Disease; Fourniers Gangrene; Gangrene, Fournier; Gangrene, Fournier's
SNOMED CT: Fournier's gangrene (398318005); Fournier gangrene (398318005)
 
Monarch Initiative: MONDO:0043352

Definition

An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFournier gangrene

Professional guidelines

PubMed

Fournier's Gangrene: Our Five-Year Series and the Role of Vacuum-Assisted Closure in the Treatment.
Gul MO, Sunamak O, Kina U, Gunay E, Akyuz C
Niger J Clin Pract 2021 Sep;24(9):1277-1282. doi: 10.4103/njcp.njcp_387_20. PMID: 34531337
Necrotising fasciitis in the central part of the body: diagnosis, management and review of the literature.
Vayvada H, Demirdover C, Menderes A, Karaca C
Int Wound J 2013 Aug;10(4):466-72. Epub 2012 Jun 13 doi: 10.1111/j.1742-481X.2012.01006.x. PMID: 22694053Free PMC Article
Complex wounds and their management.
Park H, Copeland C, Henry S, Barbul A
Surg Clin North Am 2010 Dec;90(6):1181-94. doi: 10.1016/j.suc.2010.08.001. PMID: 21074035

Recent clinical studies

Etiology

Fournier's gangrene mortality: A 17-year systematic review and meta-analysis.
El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, Mahmoud MU, Bin-Jumah M, Alkahtani S, Abdel-Daim MM
Int J Infect Dis 2020 Mar;92:218-225. Epub 2020 Jan 18 doi: 10.1016/j.ijid.2019.12.030. PMID: 31962181
SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects.
Tentolouris A, Vlachakis P, Tzeravini E, Eleftheriadou I, Tentolouris N
Int J Environ Res Public Health 2019 Aug 17;16(16) doi: 10.3390/ijerph16162965. PMID: 31426529Free PMC Article
Presentation and Diagnosis of Fournier Gangrene.
Voelzke BB, Hagedorn JC
Urology 2018 Apr;114:8-13. Epub 2017 Nov 13 doi: 10.1016/j.urology.2017.10.031. PMID: 29146218
Fournier's gangrene. A clinical review.
Singh A, Ahmed K, Aydin A, Khan MS, Dasgupta P
Arch Ital Urol Androl 2016 Oct 5;88(3):157-164. doi: 10.4081/aiua.2016.3.157. PMID: 27711086
Fournier's gangrene.
Shyam DC, Rapsang AG
Surgeon 2013 Aug;11(4):222-32. Epub 2013 Apr 8 doi: 10.1016/j.surge.2013.02.001. PMID: 23578806

Diagnosis

Scrotal Ultrasound.
Rebik K, Wagner JM, Middleton W
Radiol Clin North Am 2019 May;57(3):635-648. Epub 2019 Feb 14 doi: 10.1016/j.rcl.2019.01.007. PMID: 30928082
Fournier's Gangrene: Literature Review and Clinical Cases.
Chernyadyev SA, Ufimtseva MA, Vishnevskaya IF, Bochkarev YM, Ushakov AA, Beresneva TA, Galimzyanov FV, Khodakov VV
Urol Int 2018;101(1):91-97. Epub 2018 Jun 27 doi: 10.1159/000490108. PMID: 29949811Free PMC Article
Urologic Emergencies.
Manjunath AS, Hofer MD
Med Clin North Am 2018 Mar;102(2):373-385. Epub 2017 Dec 20 doi: 10.1016/j.mcna.2017.10.013. PMID: 29406065
Fournier's gangrene. A clinical review.
Singh A, Ahmed K, Aydin A, Khan MS, Dasgupta P
Arch Ital Urol Androl 2016 Oct 5;88(3):157-164. doi: 10.4081/aiua.2016.3.157. PMID: 27711086
Anorectal emergencies.
Lohsiriwat V
World J Gastroenterol 2016 Jul 14;22(26):5867-78. doi: 10.3748/wjg.v22.i26.5867. PMID: 27468181Free PMC Article

Therapy

SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects.
Tentolouris A, Vlachakis P, Tzeravini E, Eleftheriadou I, Tentolouris N
Int J Environ Res Public Health 2019 Aug 17;16(16) doi: 10.3390/ijerph16162965. PMID: 31426529Free PMC Article
Fournier's Gangrene: Literature Review and Clinical Cases.
Chernyadyev SA, Ufimtseva MA, Vishnevskaya IF, Bochkarev YM, Ushakov AA, Beresneva TA, Galimzyanov FV, Khodakov VV
Urol Int 2018;101(1):91-97. Epub 2018 Jun 27 doi: 10.1159/000490108. PMID: 29949811Free PMC Article
Fournier's gangrene. A clinical review.
Singh A, Ahmed K, Aydin A, Khan MS, Dasgupta P
Arch Ital Urol Androl 2016 Oct 5;88(3):157-164. doi: 10.4081/aiua.2016.3.157. PMID: 27711086
Serious and long-term adverse events associated with the therapeutic and cosmetic use of botulinum toxin.
Yiannakopoulou E
Pharmacology 2015;95(1-2):65-9. Epub 2015 Jan 21 doi: 10.1159/000370245. PMID: 25613637
Fournier's gangrene.
Shyam DC, Rapsang AG
Surgeon 2013 Aug;11(4):222-32. Epub 2013 Apr 8 doi: 10.1016/j.surge.2013.02.001. PMID: 23578806

Prognosis

Fournier gangrene: pictorial review.
Wongwaisayawan S, Krishna S, Haroon M, Nisha Y, Sheikh A
Abdom Radiol (NY) 2020 Nov;45(11):3838-3848. doi: 10.1007/s00261-020-02549-9. PMID: 32342151
Fournier's gangrene mortality: A 17-year systematic review and meta-analysis.
El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, Mahmoud MU, Bin-Jumah M, Alkahtani S, Abdel-Daim MM
Int J Infect Dis 2020 Mar;92:218-225. Epub 2020 Jan 18 doi: 10.1016/j.ijid.2019.12.030. PMID: 31962181
Fournier gangrene.
Matsuura H, Iwasa K
Cleve Clin J Med 2018 Sep;85(9):664-665. doi: 10.3949/ccjm.85a.18036. PMID: 30192736
Fournier's Gangrene: Literature Review and Clinical Cases.
Chernyadyev SA, Ufimtseva MA, Vishnevskaya IF, Bochkarev YM, Ushakov AA, Beresneva TA, Galimzyanov FV, Khodakov VV
Urol Int 2018;101(1):91-97. Epub 2018 Jun 27 doi: 10.1159/000490108. PMID: 29949811Free PMC Article
Fournier's gangrene. A clinical review.
Singh A, Ahmed K, Aydin A, Khan MS, Dasgupta P
Arch Ital Urol Androl 2016 Oct 5;88(3):157-164. doi: 10.4081/aiua.2016.3.157. PMID: 27711086

Clinical prediction guides

The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis.
Huang C, Zhong Y, Yue C, He B, Li Y, Li J
World J Emerg Surg 2023 Mar 25;18(1):23. doi: 10.1186/s13017-023-00490-y. PMID: 36966323Free PMC Article
Fournier gangrene: pictorial review.
Wongwaisayawan S, Krishna S, Haroon M, Nisha Y, Sheikh A
Abdom Radiol (NY) 2020 Nov;45(11):3838-3848. doi: 10.1007/s00261-020-02549-9. PMID: 32342151
Fournier Gangrene in Men and Women: Appearance on CT, Ultrasound, and MRI and What the Surgeon Wants to Know.
Ballard DH, Mazaheri P, Raptis CA, Lubner MG, Menias CO, Pickhardt PJ, Mellnick VM
Can Assoc Radiol J 2020 Feb;71(1):30-39. Epub 2020 Jan 28 doi: 10.1177/0846537119888396. PMID: 32063012Free PMC Article
Rectal cancer and Fournier's gangrene - current knowledge and therapeutic options.
Bruketa T, Majerovic M, Augustin G
World J Gastroenterol 2015 Aug 14;21(30):9002-20. doi: 10.3748/wjg.v21.i30.9002. PMID: 26290629Free PMC Article
Fournier's gangrene--current concepts.
Wróblewska M, Kuzaka B, Borkowski T, Kuzaka P, Kawecki D, Radziszewski P
Pol J Microbiol 2014;63(3):267-73. PMID: 25546936

Recent systematic reviews

The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis.
Huang C, Zhong Y, Yue C, He B, Li Y, Li J
World J Emerg Surg 2023 Mar 25;18(1):23. doi: 10.1186/s13017-023-00490-y. PMID: 36966323Free PMC Article
The role of hyperbaric oxygen therapy in Fournier's Gangrene: A systematic review and meta-analysis of observational studies.
Raizandha MA, Hidayatullah F, Kloping YP, Rahman IA, Djatisoesanto W, Rizaldi F
Int Braz J Urol 2022 Sep-Oct;48(5):771-781. doi: 10.1590/S1677-5538.IBJU.2022.0119. PMID: 35594328Free PMC Article
Relationship between diversional stoma and mortality rate in Fournier's gangrene: a systematic review and meta-analysis.
Sarofim M, Di Re A, Descallar J, Toh JWT
Langenbecks Arch Surg 2021 Dec;406(8):2581-2590. Epub 2021 Apr 16 doi: 10.1007/s00423-021-02175-z. PMID: 33864128
Hyperbaric Oxygenation in the Treatment of Fournier's Gangrene: A Systematic Review.
Schneidewind L, Anheuser P, Schönburg S, Wagenlehner FME, Kranz J
Urol Int 2021;105(3-4):247-256. Epub 2020 Dec 7 doi: 10.1159/000511615. PMID: 33285541Free PMC Article
Fournier's gangrene mortality: A 17-year systematic review and meta-analysis.
El-Qushayri AE, Khalaf KM, Dahy A, Mahmoud AR, Benmelouka AY, Ghozy S, Mahmoud MU, Bin-Jumah M, Alkahtani S, Abdel-Daim MM
Int J Infect Dis 2020 Mar;92:218-225. Epub 2020 Jan 18 doi: 10.1016/j.ijid.2019.12.030. PMID: 31962181

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