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Abnormal vaginal bleeding

MedGen UID:
661931
•Concept ID:
C0578503
•
Finding
SNOMED CT: Abnormal vaginal bleeding (301822002)
 
HPO: HP:0034263

Definition

Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal. [from HPO]

Professional guidelines

PubMed

Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review.
Wang X, Yang J, Wan X, Feng F, Zhao J, Ren T, Xiang Y
Orphanet J Rare Dis 2021 Nov 18;16(1):480. doi: 10.1186/s13023-021-02111-w. PMID: 34794477Free PMC Article
Uterine arteriovenous malformation - diagnosis and management.
Szpera-Goździewicz A, Gruca-Stryjak K, Bręborowicz GH, Ropacka-Lesiak M
Ginekol Pol 2018;89(5):276-279. doi: 10.5603/GP.a2018.0047. PMID: 30084480
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Recent clinical studies

Etiology

Pessaries (mechanical devices) for managing pelvic organ prolapse in women.
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Adenomyosis:A Clinico-pathological Study.
Emmanuel I, Ochigbo A, Philip A, Nyam EY
West Afr J Med 2019 Jan-Apr;36(1):88-92. PMID: 30924123
Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study.
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
Abnormal vaginal bleeding in women with gynaecological malignancies.
Adams T, Denny L
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:134-147. Epub 2016 Oct 26 doi: 10.1016/j.bpobgyn.2016.09.014. PMID: 27856158
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Diagnosis

Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study.
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
Abnormal vaginal bleeding in women with gynaecological malignancies.
Adams T, Denny L
Best Pract Res Clin Obstet Gynaecol 2017 Apr;40:134-147. Epub 2016 Oct 26 doi: 10.1016/j.bpobgyn.2016.09.014. PMID: 27856158
Imaging the Endometrium: A Pictorial Essay.
Sadro CT
Can Assoc Radiol J 2016 Aug;67(3):254-62. Epub 2016 Apr 15 doi: 10.1016/j.carj.2015.09.012. PMID: 27090929
Menstrual disorders.
Deligeoroglou E, Creatsas G
Endocr Dev 2012;22:160-170. Epub 2012 Jul 25 doi: 10.1159/000331697. PMID: 22846527
Chronic endometritis.
Michels TC
Am Fam Physician 1995 Jul;52(1):217-22. PMID: 7604765

Therapy

Pessaries (mechanical devices) for managing pelvic organ prolapse in women.
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin.
Brekelmans MP, Scheres LJ, Bleker SM, Hutten BA, Timmermans A, Büller HR, Middeldorp S
Thromb Haemost 2017 Apr 3;117(4):809-815. Epub 2017 Feb 9 doi: 10.1160/TH16-11-0874. PMID: 28180233
Mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction (HFpEF).
Capuano A, Scavone C, Vitale C, Sportiello L, Rossi F, Rosano GM, Coats AJ
Int J Cardiol 2015 Dec 1;200:15-9. doi: 10.1016/j.ijcard.2015.07.038. PMID: 26404747
Causes and Diagnosis of Abnormal Vaginal Bleeding.
Sokol E, Peddinti R
Pediatr Ann 2015 Jul;44(7):e164-7. doi: 10.3928/00904481-20150710-09. PMID: 26171705
Combined oral contraception.
Miller C, Murtagh J
Aust Fam Physician 1992 Dec;21(12):1787-8. PMID: 1476509

Prognosis

Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin.
Brekelmans MP, Scheres LJ, Bleker SM, Hutten BA, Timmermans A, Büller HR, Middeldorp S
Thromb Haemost 2017 Apr 3;117(4):809-815. Epub 2017 Feb 9 doi: 10.1160/TH16-11-0874. PMID: 28180233
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Müllerian adenosarcoma: a review of cases and literature.
Huang PS, Chang WC, Huang SC
Eur J Gynaecol Oncol 2014;35(6):617-20. PMID: 25556263
Dysfunctional uterine bleeding in adolescents.
Lavin C
Curr Opin Pediatr 1996 Aug;8(4):328-32. doi: 10.1097/00008480-199608000-00005. PMID: 8954262
Anovulatory uterine bleeding.
Poindexter AN, Ritter MB
Compr Ther 1983 Dec;9(12):65-71. PMID: 6368113

Clinical prediction guides

Pessaries (mechanical devices) for managing pelvic organ prolapse in women.
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study.
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
ACR appropriateness criteria(®) on abnormal vaginal bleeding.
Bennett GL, Andreotti RF, Lee SI, Dejesus Allison SO, Brown DL, Dubinsky T, Glanc P, Mitchell DG, Podrasky AE, Shipp TD, Siegel CL, Wong-You-Cheong JJ, Zelop CM
J Am Coll Radiol 2011 Jul;8(7):460-8. doi: 10.1016/j.jacr.2011.03.011. PMID: 21723482
Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature.
Dimitraki M, Tsikouras P, Bouchlariotou S, Dafopoulos A, Liberis V, Maroulis G, Teichmann AT
Arch Gynecol Obstet 2011 Feb;283(2):261-6. Epub 2010 Aug 4 doi: 10.1007/s00404-010-1601-3. PMID: 20683604Free PMC Article
Progestin-only oral contraception: a comprehensive review.
McCann MF, Potter LS
Contraception 1994 Dec;50(6 Suppl 1):S1-195. PMID: 10226677

Recent systematic reviews

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.
Romero SA, Young K, Hickey M, Su HI
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD007245. doi: 10.1002/14651858.CD007245.pub4. PMID: 33348436Free PMC Article
Pessaries (mechanical devices) for managing pelvic organ prolapse in women.
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Immediate versus delayed postpartum insertion of contraceptive implant for contraception.
Sothornwit J, Werawatakul Y, Kaewrudee S, Lumbiganon P, Laopaiboon M
Cochrane Database Syst Rev 2017 Apr 22;4(4):CD011913. doi: 10.1002/14651858.CD011913.pub2. PMID: 28432791Free PMC Article
Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.
Dominick S, Hickey M, Chin J, Su HI
Cochrane Database Syst Rev 2015 Dec 9;2015(12):CD007245. doi: 10.1002/14651858.CD007245.pub3. PMID: 26649916Free PMC Article
Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.
Chin J, Konje JC, Hickey M
Cochrane Database Syst Rev 2009 Oct 7;(4):CD007245. doi: 10.1002/14651858.CD007245.pub2. PMID: 19821400

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