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Chronic schizophrenia

MedGen UID:
66383
•Concept ID:
C0221765
•
Mental or Behavioral Dysfunction
Synonyms: Chronic Schizophrenia; Chronic schizophrenic
SNOMED CT: Chronic schizophrenic (83746006); Chronic schizophrenia (83746006)

Professional guidelines

PubMed

Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies.
Schoevers J, Leweke JE, Leweke FM
Curr Opin Psychiatry 2020 May;33(3):185-191. doi: 10.1097/YCO.0000000000000596. PMID: 32073423
Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.
Marini S, De Berardis D, Vellante F, Santacroce R, Orsolini L, Valchera A, Girinelli G, Carano A, Fornaro M, Gambi F, Martinotti G, Di Giannantonio M
Mediators Inflamm 2016;2016:3476240. Epub 2016 Jul 25 doi: 10.1155/2016/3476240. PMID: 27524864Free PMC Article
Treatment of schizophrenia.
Kane JM
Schizophr Bull 1987;13(1):133-56. doi: 10.1093/schbul/13.1.133. PMID: 2885912

Recent clinical studies

Etiology

Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates.
Herold CJ, Lässer MM, Schröder J
J Neuropsychol 2023 Mar;17(1):89-107. Epub 2022 Sep 5 doi: 10.1111/jnp.12288. PMID: 36065152
Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.
Dixon BJ, Kumar J, Danielmeier C
Neurosci Biobehav Rev 2022 Jan;132:224-247. Epub 2021 Dec 2 doi: 10.1016/j.neubiorev.2021.11.010. PMID: 34864431Free PMC Article
Brain ventricular volume changes in schizophrenia. A narrative review.
Svancer P, Spaniel F
Neurosci Lett 2021 Aug 10;759:136065. Epub 2021 Jun 16 doi: 10.1016/j.neulet.2021.136065. PMID: 34146640
Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.
Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669Free PMC Article
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Diagnosis

Regulatory T cells mediate insomnia-related psychotic symptoms and cognitive impairment in chronic schizophrenia patients.
Wang M, Zhou Z, Tang W, Peng M, Chen L, Lou M, Fang X, Xu H
J Psychiatr Res 2023 Jul;163:102-108. Epub 2023 May 13 doi: 10.1016/j.jpsychires.2023.05.011. PMID: 37207432
Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.
Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669Free PMC Article
Sleep-related psychosis.
Frase L, Sixt B, Nissen C
BMJ Case Rep 2013 Jul 8;2013 doi: 10.1136/bcr-2013-009373. PMID: 23839606Free PMC Article
Schizotypal personality disorder.
Chemerinski E, Triebwasser J, Roussos P, Siever LJ
J Pers Disord 2013 Oct;27(5):652-79. Epub 2012 Aug 28 doi: 10.1521/pedi_2012_26_053. PMID: 22928856
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Therapy

Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies.
Schoevers J, Leweke JE, Leweke FM
Curr Opin Psychiatry 2020 May;33(3):185-191. doi: 10.1097/YCO.0000000000000596. PMID: 32073423
The Use of Long-Acting Injectable Antipsychotics in Schizophrenia: Evaluating the Evidence.
Correll CU, Citrome L, Haddad PM, Lauriello J, Olfson M, Calloway SM, Kane JM
J Clin Psychiatry 2016;77(suppl 3):1-24. doi: 10.4088/JCP.15032su1. PMID: 27732772
Polyunsaturated fatty acids in emerging psychosis.
Mossaheb N, Schloegelhofer M, Schaefer MR, Fusar-Poli P, Smesny S, McGorry P, Berger G, Amminger GP
Curr Pharm Des 2012;18(4):576-91. doi: 10.2174/138161212799316055. PMID: 22239591
Aripiprazole.
McGavin JK, Goa KL
CNS Drugs 2002;16(11):779-86; discussion 787-8. doi: 10.2165/00023210-200216110-00008. PMID: 12383035
Clinical review of risperidone.
Chouinard G, Arnott W
Can J Psychiatry 1993 Sep;38 Suppl 3:S89-95. PMID: 7504574

Prognosis

Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.
Dixon BJ, Kumar J, Danielmeier C
Neurosci Biobehav Rev 2022 Jan;132:224-247. Epub 2021 Dec 2 doi: 10.1016/j.neubiorev.2021.11.010. PMID: 34864431Free PMC Article
Brain ventricular volume changes in schizophrenia. A narrative review.
Svancer P, Spaniel F
Neurosci Lett 2021 Aug 10;759:136065. Epub 2021 Jun 16 doi: 10.1016/j.neulet.2021.136065. PMID: 34146640
Ageing with schizophrenia: an update.
Solomon HV, Sinopoli M, DeLisi LE
Curr Opin Psychiatry 2021 May 1;34(3):266-274. doi: 10.1097/YCO.0000000000000694. PMID: 33534420
Mismatch Negativity in First-Episode Schizophrenia: A Meta-Analysis.
Haigh SM, Coffman BA, Salisbury DF
Clin EEG Neurosci 2017 Jan;48(1):3-10. Epub 2016 May 11 doi: 10.1177/1550059416645980. PMID: 27170669Free PMC Article
Somatic Comorbidity in Schizophrenia: Some Possible Biological Mechanisms Across the Life Span.
Dieset I, Andreassen OA, Haukvik UK
Schizophr Bull 2016 Nov;42(6):1316-1319. Epub 2016 Mar 31 doi: 10.1093/schbul/sbw028. PMID: 27033328Free PMC Article

Clinical prediction guides

Neurodegenerative model of schizophrenia: Growing evidence to support a revisit.
Stone WS, Phillips MR, Yang LH, Kegeles LS, Susser ES, Lieberman JA
Schizophr Res 2022 May;243:154-162. Epub 2022 Mar 25 doi: 10.1016/j.schres.2022.03.004. PMID: 35344853Free PMC Article
Color painting predicts clinical symptoms in chronic schizophrenia patients via deep learning.
Shen H, Wang SH, Zhang Y, Wang H, Li F, Lucas MV, Zhang YD, Liu Y, Yuan TF
BMC Psychiatry 2021 Oct 22;21(1):522. doi: 10.1186/s12888-021-03452-3. PMID: 34686178Free PMC Article
Association between empathy and clinical symptoms in chronic schizophrenia: A large sample study based on Chinese Han population.
Wang W, Zhou Y, Liu R, Wei S, Xu H, Wang J, Wang L, Trinh TH, Wu HE, Wang D, Zhang X
J Psychiatr Res 2021 Jul;139:106-112. Epub 2021 May 22 doi: 10.1016/j.jpsychires.2021.05.046. PMID: 34058648
Insomnia, suicidal ideation, and psychopathology in Chinese patients with chronic schizophrenia.
Miller BJ, McCall WV, Xia L, Zhang Y, Li W, Yao X, Liu H
Prog Neuropsychopharmacol Biol Psychiatry 2021 Dec 20;111:110202. Epub 2020 Dec 4 doi: 10.1016/j.pnpbp.2020.110202. PMID: 33285266
Anhedonia and schizophrenia.
Harrow M, Grinker RR, Holzman PS, Kayton L
Am J Psychiatry 1977 Jul;134(7):794-7. doi: 10.1176/ajp.134.7.794. PMID: 869058

Recent systematic reviews

Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic review and dose-response meta-analysis.
Wu H, Siafis S, Wang D, Burschinski A, Schneider-Thoma J, Priller J, Davis JM, Leucht S
Eur Neuropsychopharmacol 2023 Jul;72:40-49. Epub 2023 Apr 17 doi: 10.1016/j.euroneuro.2023.03.015. PMID: 37075639
Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review and network meta-analysis.
Halstead S, Siskind D, Amft M, Wagner E, Yakimov V, Shih-Jung Liu Z, Walder K, Warren N
Lancet Psychiatry 2023 Apr;10(4):260-271. Epub 2023 Feb 27 doi: 10.1016/S2215-0366(23)00025-1. PMID: 36863384
A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia.
di Hou M, Santoro V, Biondi A, Shergill SS, Premoli I
J Psychiatry Neurosci 2021 Nov-Dec;46(6):E675-E701. Epub 2021 Dec 21 doi: 10.1503/jpn.210006. PMID: 34933940Free PMC Article
Antipsychotic-induced extrapyramidal side effects: A systematic review and meta-analysis of observational studies.
Ali T, Sisay M, Tariku M, Mekuria AN, Desalew A
PLoS One 2021;16(9):e0257129. Epub 2021 Sep 10 doi: 10.1371/journal.pone.0257129. PMID: 34506552Free PMC Article
A systematic review and meta-analysis of cognitive remediation in early schizophrenia.
Revell ER, Neill JC, Harte M, Khan Z, Drake RJ
Schizophr Res 2015 Oct;168(1-2):213-22. Epub 2015 Aug 21 doi: 10.1016/j.schres.2015.08.017. PMID: 26305063

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