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Gastrointestinal obstruction

MedGen UID:
66735
Concept ID:
C0236124
Disease or Syndrome
Synonyms: GI obstruction; Obstruction in digestive tract
SNOMED CT: Gastrointestinal obstruction (126765001)
 
HPO: HP:0004796

Conditions with this feature

Currarino triad
MedGen UID:
323460
Concept ID:
C1531773
Disease or Syndrome
The Currarino syndrome is an autosomal dominant form of hereditary sacral dysgenesis that classically consists of the triad of sacral malformation, presacral mass, and anorectal malformations. However, other features include neonatal-onset bowel obstruction, chronic constipation, recurrent perianal sepsis, renal/urinary tract anomalies, female internal genital anomalies, tethered spinal cord, and anterior meningocele. There is marked inter- and intrafamilial variability, and up to 33% of patients are asymptomatic (summary by Wang et al., 2006).

Professional guidelines

PubMed

Kamposioras K, Geraghty J, Appleyard J, Dawod M, Papadimitriou K, Lamarca A, Anthoney A
J Gastrointest Cancer 2022 Dec;53(4):1050-1065. Epub 2021 Oct 14 doi: 10.1007/s12029-021-00718-7. PMID: 34648136Free PMC Article
Kennedy J, Goudie D, Blair E, Chandler K, Joss S, McKay V, Green A, Armstrong R, Lees M, Kamien B, Hopper B, Tan TY, Yap P, Stark Z, Okamoto N, Miyake N, Matsumoto N, Macnamara E, Murphy JL, McCormick E, Hakonarson H, Falk MJ, Li D, Blackburn P, Klee E, Babovic-Vuksanovic D, Schelley S, Hudgins L, Kant S, Isidor B, Cogne B, Bradbury K, Williams M, Patel C, Heussler H, Duff-Farrier C, Lakeman P, Scurr I, Kini U, Elting M, Reijnders M, Schuurs-Hoeijmakers J, Wafik M, Blomhoff A, Ruivenkamp CAL, Nibbeling E, Dingemans AJM, Douine ED, Nelson SF; DDD Study,, Hempel M, Bierhals T, Lessel D, Johannsen J, Arboleda VA, Newbury-Ecob R
Genet Med 2019 Apr;21(4):850-860. Epub 2018 Sep 24 doi: 10.1038/s41436-018-0259-2. PMID: 30245513Free PMC Article
Lau PE, Cruz S, Cassady CI, Mehollin-Ray AR, Ruano R, Keswani S, Lee TC, Olutoye OO, Cass DL
J Pediatr Surg 2017 May;52(5):722-725. Epub 2017 Jan 29 doi: 10.1016/j.jpedsurg.2017.01.028. PMID: 28216077

Recent clinical studies

Etiology

Šefr R, Zapletal O, Krsička P, Novotný I, Pacal M, Němec L, Jedlička V
Rozhl Chir 2023 Spring;102(2):60-63. doi: 10.33699/PIS.2023.102.2.60-63. PMID: 37185027
Xiao J, Hao LW, Wang J, Yu XS, You JY, Li ZJ, Mao HD, Meng XY, Feng JX
World J Pediatr 2023 Jul;19(7):644-651. Epub 2023 Mar 1 doi: 10.1007/s12519-023-00686-x. PMID: 36857021Free PMC Article
Warner MA, Meyerhoff KL, Warner ME, Posner KL, Stephens L, Domino KB
Anesthesiology 2021 Aug 1;135(2):284-291. doi: 10.1097/ALN.0000000000003831. PMID: 34019629
Kennedy J, Goudie D, Blair E, Chandler K, Joss S, McKay V, Green A, Armstrong R, Lees M, Kamien B, Hopper B, Tan TY, Yap P, Stark Z, Okamoto N, Miyake N, Matsumoto N, Macnamara E, Murphy JL, McCormick E, Hakonarson H, Falk MJ, Li D, Blackburn P, Klee E, Babovic-Vuksanovic D, Schelley S, Hudgins L, Kant S, Isidor B, Cogne B, Bradbury K, Williams M, Patel C, Heussler H, Duff-Farrier C, Lakeman P, Scurr I, Kini U, Elting M, Reijnders M, Schuurs-Hoeijmakers J, Wafik M, Blomhoff A, Ruivenkamp CAL, Nibbeling E, Dingemans AJM, Douine ED, Nelson SF; DDD Study,, Hempel M, Bierhals T, Lessel D, Johannsen J, Arboleda VA, Newbury-Ecob R
Genet Med 2019 Apr;21(4):850-860. Epub 2018 Sep 24 doi: 10.1038/s41436-018-0259-2. PMID: 30245513Free PMC Article
Lau PE, Cruz S, Cassady CI, Mehollin-Ray AR, Ruano R, Keswani S, Lee TC, Olutoye OO, Cass DL
J Pediatr Surg 2017 May;52(5):722-725. Epub 2017 Jan 29 doi: 10.1016/j.jpedsurg.2017.01.028. PMID: 28216077

Diagnosis

Amir Ali AA, Hameed K, Nawaz A, Khan I, Perveen S
J Coll Physicians Surg Pak 2022 Dec;32(12):SS100-SS101. doi: 10.29271/jcpsp.2022.Supp0.SS100. PMID: 36597304
Kennedy J, Goudie D, Blair E, Chandler K, Joss S, McKay V, Green A, Armstrong R, Lees M, Kamien B, Hopper B, Tan TY, Yap P, Stark Z, Okamoto N, Miyake N, Matsumoto N, Macnamara E, Murphy JL, McCormick E, Hakonarson H, Falk MJ, Li D, Blackburn P, Klee E, Babovic-Vuksanovic D, Schelley S, Hudgins L, Kant S, Isidor B, Cogne B, Bradbury K, Williams M, Patel C, Heussler H, Duff-Farrier C, Lakeman P, Scurr I, Kini U, Elting M, Reijnders M, Schuurs-Hoeijmakers J, Wafik M, Blomhoff A, Ruivenkamp CAL, Nibbeling E, Dingemans AJM, Douine ED, Nelson SF; DDD Study,, Hempel M, Bierhals T, Lessel D, Johannsen J, Arboleda VA, Newbury-Ecob R
Genet Med 2019 Apr;21(4):850-860. Epub 2018 Sep 24 doi: 10.1038/s41436-018-0259-2. PMID: 30245513Free PMC Article
Hucl T
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):691-707. Epub 2013 Sep 15 doi: 10.1016/j.bpg.2013.09.001. PMID: 24160928
Kucik CJ, Martin GL, Sortor BV
Am Fam Physician 2004 Mar 1;69(5):1161-8. PMID: 15023017
Bissonnette B, Sullivan PJ
Can J Anaesth 1991 Jul;38(5):668-76. doi: 10.1007/BF03008206. PMID: 1934223

Therapy

Capurso G, Tacelli M, Vanella G, Ponz de Leon Pisani R, Dell'Anna G, Abati M, Mele R, Lauri G, Panaitescu A, Nunziata R, Zaccari P, Archibugi L, Arcidiacono PG
Expert Rev Gastroenterol Hepatol 2023 Dec;17(12):1267-1283. Epub 2024 Jan 17 doi: 10.1080/17474124.2023.2295498. PMID: 38093702
Ezaizi Y, Hasan B, Manini ML, Absah I
Paediatr Drugs 2022 Sep;24(5):539-545. Epub 2022 Jun 30 doi: 10.1007/s40272-022-00518-x. PMID: 35768647
Voldby AW, Boolsen AW, Aaen AA, Burcharth J, Ekeløf S, Loprete R, Jønck S, Eskandarani HA, Thygesen LC, Møller AM, Brandstrup B
J Gastrointest Surg 2022 Sep;26(9):1930-1941. Epub 2022 May 23 doi: 10.1007/s11605-021-05240-6. PMID: 35606601
Kucik CJ, Martin GL, Sortor BV
Am Fam Physician 2004 Mar 1;69(5):1161-8. PMID: 15023017
Knodel LC, Talbert RL
Med Toxicol 1987 Jan-Feb;2(1):10-32. doi: 10.1007/BF03259858. PMID: 3547004

Prognosis

Ni M, Zhu X, Liu W, Gu L, Zhu Y, Cao P, Gu Y, Xu Y, Dai C, Wu X, Yang Y, Zhou C, Li J
BMC Pregnancy Childbirth 2023 Jul 8;23(1):503. doi: 10.1186/s12884-023-05828-7. PMID: 37422671Free PMC Article
Blumenthaler AN, Bruera E, Badgwell BD
Ann Surg 2023 Feb 1;277(2):284-290. Epub 2023 Jan 10 doi: 10.1097/SLA.0000000000004974. PMID: 36745760Free PMC Article
Pujara D, Chiang YJ, Cormier JN, Bruera E, Badgwell B
J Am Coll Surg 2017 Jul;225(1):53-59. Epub 2017 May 5 doi: 10.1016/j.jamcollsurg.2017.04.033. PMID: 28483604
Lau PE, Cruz S, Cassady CI, Mehollin-Ray AR, Ruano R, Keswani S, Lee TC, Olutoye OO, Cass DL
J Pediatr Surg 2017 May;52(5):722-725. Epub 2017 Jan 29 doi: 10.1016/j.jpedsurg.2017.01.028. PMID: 28216077
van Geenen RC, van Gulik TM, Busch OR, de Wit LT, Obertop H, Gouma DJ
Br J Surg 2001 Nov;88(11):1467-71. doi: 10.1046/j.0007-1323.2001.01900.x. PMID: 11683742

Clinical prediction guides

Voldby AW, Boolsen AW, Aaen AA, Burcharth J, Ekeløf S, Loprete R, Jønck S, Eskandarani HA, Thygesen LC, Møller AM, Brandstrup B
J Gastrointest Surg 2022 Sep;26(9):1930-1941. Epub 2022 May 23 doi: 10.1007/s11605-021-05240-6. PMID: 35606601
Syal S, Sen A, Sugandhi N, Nanda M, Jhadav A
Afr J Paediatr Surg 2020 Jan-Jun;17(1-2):18-22. doi: 10.4103/ajps.AJPS_27_17. PMID: 33106448Free PMC Article
Leung AKC, Hon KL
Curr Pediatr Rev 2019;15(3):164-169. doi: 10.2174/1573396315666190313163530. PMID: 30868957
Hosoe N, Takabayashi K, Ogata H, Kanai T
Dig Endosc 2019 Sep;31(5):498-507. Epub 2019 Feb 10 doi: 10.1111/den.13346. PMID: 30656743
Lau PE, Cruz S, Cassady CI, Mehollin-Ray AR, Ruano R, Keswani S, Lee TC, Olutoye OO, Cass DL
J Pediatr Surg 2017 May;52(5):722-725. Epub 2017 Jan 29 doi: 10.1016/j.jpedsurg.2017.01.028. PMID: 28216077

Recent systematic reviews

Seta T, Iwagami H, Agatsuma N, Noma A, Ikenouchi M, Kubo K, Akamatsu T, Uenoyama Y, Ito D, Yamashita Y, Nakayama T
Eur J Gastroenterol Hepatol 2023 Oct 1;35(10):1097-1106. Epub 2023 Jul 28 doi: 10.1097/MEG.0000000000002622. PMID: 37577799
Pettit S, Chalmers D
J Pediatr Urol 2021 Dec;17(6):763-768. Epub 2021 Sep 11 doi: 10.1016/j.jpurol.2021.09.003. PMID: 34538561
Pratt J, Green S
Clin Nutr ESPEN 2017 Oct;21:59-65. Epub 2017 Jun 26 doi: 10.1016/j.clnesp.2017.05.004. PMID: 30014870
Wedlake L, Slack N, Andreyev HJ, Whelan K
Inflamm Bowel Dis 2014 Mar;20(3):576-86. doi: 10.1097/01.MIB.0000437984.92565.31. PMID: 24445775
Yang Z, Wu Q, Wang F, Ye X, Qi X, Fan D
Int J Med Sci 2013;10(7):825-35. Epub 2013 Apr 27 doi: 10.7150/ijms.5969. PMID: 23794946Free PMC Article

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