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Male Breast Carcinoma In Situ

MedGen UID:
673213
•Concept ID:
C0686328
•
Neoplastic Process
Synonym: Carcinoma in situ of male breast
SNOMED CT: Carcinoma in situ of male breast (92652009)

Definition

A proliferation of atypical neoplastic epithelial cells confined to the mammary ducts of the male breast. It includes the entire spectrum of carcinoma in situ observed in the female breast. It usually develops in the retroareolar region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMale Breast Carcinoma In Situ

Professional guidelines

PubMed

Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ.
Gupta A, Jhawar SR, Sayan M, Yehia ZA, Haffty BG, Yu JB, Wang SY
J Clin Oncol 2021 Jul 20;39(21):2386-2396. Epub 2021 May 21 doi: 10.1200/JCO.21.00831. PMID: 34019456Free PMC Article
Breast cancer in the oldest old (≥ 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review.
Di Lascio S, Tognazzo E, Bigiotti S, Bonollo M, Costa A, Pagani O, Meani F
Eur J Surg Oncol 2021 Apr;47(4):796-803. Epub 2020 Oct 13 doi: 10.1016/j.ejso.2020.10.008. PMID: 33097334
The differential diagnosis of pagetoid cells in the epidermis.
Kohler S, Rouse RV, Smoller BR
Mod Pathol 1998 Jan;11(1):79-92. PMID: 9556428

Recent clinical studies

Etiology

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Prognostic and Biologic Significance of ERBB2-Low Expression in Early-Stage Breast Cancer.
Tarantino P, Jin Q, Tayob N, Jeselsohn RM, Schnitt SJ, Vincuilla J, Parker T, Tyekucheva S, Li T, Lin NU, Hughes ME, Weiss AC, King TA, Mittendorf EA, Curigliano G, Tolaney SM
JAMA Oncol 2022 Aug 1;8(8):1177-1183. doi: 10.1001/jamaoncol.2022.2286. PMID: 35737367Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Cancer overdiagnosis: a biological challenge and clinical dilemma.
Srivastava S, Koay EJ, Borowsky AD, De Marzo AM, Ghosh S, Wagner PD, Kramer BS
Nat Rev Cancer 2019 Jun;19(6):349-358. doi: 10.1038/s41568-019-0142-8. PMID: 31024081Free PMC Article

Diagnosis

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Male Breast Cancer in Australia.
Lomma C, Chan A, Chih H, Reid C, Peter W
Asia Pac J Clin Oncol 2021 Apr;17(2):e57-e62. Epub 2020 Jan 19 doi: 10.1111/ajco.13299. PMID: 31957255
Cancer overdiagnosis: a biological challenge and clinical dilemma.
Srivastava S, Koay EJ, Borowsky AD, De Marzo AM, Ghosh S, Wagner PD, Kramer BS
Nat Rev Cancer 2019 Jun;19(6):349-358. doi: 10.1038/s41568-019-0142-8. PMID: 31024081Free PMC Article

Therapy

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Prognostic and Biologic Significance of ERBB2-Low Expression in Early-Stage Breast Cancer.
Tarantino P, Jin Q, Tayob N, Jeselsohn RM, Schnitt SJ, Vincuilla J, Parker T, Tyekucheva S, Li T, Lin NU, Hughes ME, Weiss AC, King TA, Mittendorf EA, Curigliano G, Tolaney SM
JAMA Oncol 2022 Aug 1;8(8):1177-1183. doi: 10.1001/jamaoncol.2022.2286. PMID: 35737367Free PMC Article
Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.
Ross JS, Fakih M, Ali SM, Elvin JA, Schrock AB, Suh J, Vergilio JA, Ramkissoon S, Severson E, Daniel S, Fabrizio D, Frampton G, Sun J, Miller VA, Stephens PJ, Gay LM
Cancer 2018 Apr 1;124(7):1358-1373. Epub 2018 Jan 16 doi: 10.1002/cncr.31125. PMID: 29338072Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Prognosis

Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Prognostic and Biologic Significance of ERBB2-Low Expression in Early-Stage Breast Cancer.
Tarantino P, Jin Q, Tayob N, Jeselsohn RM, Schnitt SJ, Vincuilla J, Parker T, Tyekucheva S, Li T, Lin NU, Hughes ME, Weiss AC, King TA, Mittendorf EA, Curigliano G, Tolaney SM
JAMA Oncol 2022 Aug 1;8(8):1177-1183. doi: 10.1001/jamaoncol.2022.2286. PMID: 35737367Free PMC Article
Male breast cancer: an update.
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Cancer overdiagnosis: a biological challenge and clinical dilemma.
Srivastava S, Koay EJ, Borowsky AD, De Marzo AM, Ghosh S, Wagner PD, Kramer BS
Nat Rev Cancer 2019 Jun;19(6):349-358. doi: 10.1038/s41568-019-0142-8. PMID: 31024081Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Clinical prediction guides

Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database.
Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM
JAMA Oncol 2023 Apr 1;9(4):500-510. doi: 10.1001/jamaoncol.2022.7476. PMID: 36821125Free PMC Article
Prognostic and Biologic Significance of ERBB2-Low Expression in Early-Stage Breast Cancer.
Tarantino P, Jin Q, Tayob N, Jeselsohn RM, Schnitt SJ, Vincuilla J, Parker T, Tyekucheva S, Li T, Lin NU, Hughes ME, Weiss AC, King TA, Mittendorf EA, Curigliano G, Tolaney SM
JAMA Oncol 2022 Aug 1;8(8):1177-1183. doi: 10.1001/jamaoncol.2022.2286. PMID: 35737367Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Cancer overdiagnosis: a biological challenge and clinical dilemma.
Srivastava S, Koay EJ, Borowsky AD, De Marzo AM, Ghosh S, Wagner PD, Kramer BS
Nat Rev Cancer 2019 Jun;19(6):349-358. doi: 10.1038/s41568-019-0142-8. PMID: 31024081Free PMC Article
Assessment of a HER2 scoring system for colorectal cancer: results from a validation study.
Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M
Mod Pathol 2015 Nov;28(11):1481-91. Epub 2015 Oct 9 doi: 10.1038/modpathol.2015.98. PMID: 26449765

Recent systematic reviews

Aspects to consider regarding breast cancer risk in trans men: A systematic review and risk management approach.
Wahlström E, Audisio RA, Selvaggi G
PLoS One 2024;19(3):e0299333. Epub 2024 Mar 7 doi: 10.1371/journal.pone.0299333. PMID: 38451995Free PMC Article
Paget's disease of the male breast in the 21st century: A systematic review.
Adams SJ, Kanthan R
Breast 2016 Oct;29:14-23. Epub 2016 Jul 6 doi: 10.1016/j.breast.2016.06.015. PMID: 27394005
The identification of incident cancers in UK primary care databases: a systematic review.
Rañopa M, Douglas I, van Staa T, Smeeth L, Klungel O, Reynolds R, Bhaskaran K
Pharmacoepidemiol Drug Saf 2015 Jan;24(1):11-8. Epub 2014 Nov 24 doi: 10.1002/pds.3729. PMID: 25421570
Cancer risk models and preselection for screening.
Stegeman I, Bossuyt PM
Cancer Epidemiol 2012 Oct;36(5):461-9. Epub 2012 Jul 25 doi: 10.1016/j.canep.2012.06.010. PMID: 22841151

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