U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Widened mediastinum

MedGen UID:
677085
•Concept ID:
C0746459
•
Finding
Synonym: Mediastinal widening
SNOMED CT: Mediastinal widening (363646005); Widened mediastinum (363646005)
 
HPO: HP:0034501

Definition

Abnormal increase in the width of the mediastinum, often defined as being greater than 6 to 8 cm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWidened mediastinum

Professional guidelines

PubMed

Inhalational anthrax: threat, clinical presentation, and treatment.
Henry L
J Am Acad Nurse Pract 2001 Apr;13(4):164-8; quiz 169-70. doi: 10.1111/j.1745-7599.2001.tb00241.x. PMID: 11930529
Diagnosis and management of blunt great vessel trauma.
von Segesser LK, Fischer A, Vogt P, Turina M
J Card Surg 1997 Mar-Apr;12(2 Suppl):181-6; discussion 186-92. PMID: 9271744
Thoracic aortic dissection or aneurysm: clinical presentation, diagnostic imaging and initial management in a tertiary referral centre.
Hennessy TG, Smith D, McCann HA, McCarthy C, Sugrue DD
Ir J Med Sci 1996 Oct-Dec;165(4):259-62. doi: 10.1007/BF02943084. PMID: 8990649

Recent clinical studies

Etiology

Blunt Traumatic Aortic Injury in the Pan-scan Era.
Yu L, Baumann BM, Raja AS, Mower WR, Langdorf MI, Medak AJ, Anglin DR, Hendey GW, Nishijima D, Rodriguez RM
Acad Emerg Med 2020 Apr;27(4):291-296. Epub 2019 Dec 30 doi: 10.1111/acem.13900. PMID: 31811732
Initial chest X-ray in multiple trauma patients: Still works!
Koci J, Kocova E, Hyspler R, Lochman P, Berkova J, Trlica J, Dedek T
Neuro Endocrinol Lett 2019 Dec;40(7-8):305-307. PMID: 32304365
Blunt Trauma: What Is Behind the Widened Mediastinum on Chest X-Ray (CXR)?
Vasileiou G, Qian S, Al-Ghamdi H, Pace D, Rattan R, Mulder M, Namias N, Dante Yeh D
J Surg Res 2019 Nov;243:23-26. Epub 2019 May 28 doi: 10.1016/j.jss.2019.04.079. PMID: 31151033
Aortic dissection.
Prisant LM, Nalamolu VR
J Clin Hypertens (Greenwich) 2005 Jun;7(6):367-71. doi: 10.1111/j.1524-6175.2005.04116.x. PMID: 16088302Free PMC Article
Post-traumatic hepatic pseudoaneurysms in children.
Sidhu MK, Shaw DW, Daly CP, Waldhausen JH, Coldwell D
Pediatr Radiol 1999 Jan;29(1):46-52. doi: 10.1007/s002470050532. PMID: 9880616

Diagnosis

Misdiagnosis of aortic dissection: A systematic review of the literature.
Lovatt S, Wong CW, Schwarz K, Borovac JA, Lo T, Gunning M, Phan T, Patwala A, Barker D, Mallen CD, Kwok CS
Am J Emerg Med 2022 Mar;53:16-22. Epub 2021 Dec 4 doi: 10.1016/j.ajem.2021.11.047. PMID: 34968970
Blunt Traumatic Aortic Injury in the Pan-scan Era.
Yu L, Baumann BM, Raja AS, Mower WR, Langdorf MI, Medak AJ, Anglin DR, Hendey GW, Nishijima D, Rodriguez RM
Acad Emerg Med 2020 Apr;27(4):291-296. Epub 2019 Dec 30 doi: 10.1111/acem.13900. PMID: 31811732
Aortic dissection.
Prisant LM, Nalamolu VR
J Clin Hypertens (Greenwich) 2005 Jun;7(6):367-71. doi: 10.1111/j.1524-6175.2005.04116.x. PMID: 16088302Free PMC Article
Diagnosis and management of blunt great vessel trauma.
von Segesser LK, Fischer A, Vogt P, Turina M
J Card Surg 1997 Mar-Apr;12(2 Suppl):181-6; discussion 186-92. PMID: 9271744
Anthrax pneumonia.
Penn CC, Klotz SA
Semin Respir Infect 1997 Mar;12(1):28-30. PMID: 9097373

Therapy

Clinical Examination for Acute Aortic Dissection: A Systematic Review and Meta-analysis.
Ohle R, Kareemi HK, Wells G, Perry JJ
Acad Emerg Med 2018 Apr;25(4):397-412. Epub 2018 Jan 24 doi: 10.1111/acem.13360. PMID: 29265487
Inhalational anthrax: threat, clinical presentation, and treatment.
Henry L
J Am Acad Nurse Pract 2001 Apr;13(4):164-8; quiz 169-70. doi: 10.1111/j.1745-7599.2001.tb00241.x. PMID: 11930529
Routine helical computed tomographic evaluation of the mediastinum in high-risk blunt trauma patients.
Demetriades D, Gomez H, Velmahos GC, Asensio JA, Murray J, Cornwell EE 3rd, Alo K, Berne TV
Arch Surg 1998 Oct;133(10):1084-8. doi: 10.1001/archsurg.133.10.1084. PMID: 9790205
Anthrax pneumonia.
Penn CC, Klotz SA
Semin Respir Infect 1997 Mar;12(1):28-30. PMID: 9097373
Aortic dissection: a statistical analysis of the usefulness of plain chest radiographic findings.
Jagannath AS, Sos TA, Lockhart SH, Saddekni S, Sniderman KW
AJR Am J Roentgenol 1986 Dec;147(6):1123-6. doi: 10.2214/ajr.147.6.1123. PMID: 3490744

Prognosis

Blunt Traumatic Aortic Injury in the Pan-scan Era.
Yu L, Baumann BM, Raja AS, Mower WR, Langdorf MI, Medak AJ, Anglin DR, Hendey GW, Nishijima D, Rodriguez RM
Acad Emerg Med 2020 Apr;27(4):291-296. Epub 2019 Dec 30 doi: 10.1111/acem.13900. PMID: 31811732
Blunt Trauma: What Is Behind the Widened Mediastinum on Chest X-Ray (CXR)?
Vasileiou G, Qian S, Al-Ghamdi H, Pace D, Rattan R, Mulder M, Namias N, Dante Yeh D
J Surg Res 2019 Nov;243:23-26. Epub 2019 May 28 doi: 10.1016/j.jss.2019.04.079. PMID: 31151033
Aortic dissection.
Prisant LM, Nalamolu VR
J Clin Hypertens (Greenwich) 2005 Jun;7(6):367-71. doi: 10.1111/j.1524-6175.2005.04116.x. PMID: 16088302Free PMC Article
Post-traumatic hepatic pseudoaneurysms in children.
Sidhu MK, Shaw DW, Daly CP, Waldhausen JH, Coldwell D
Pediatr Radiol 1999 Jan;29(1):46-52. doi: 10.1007/s002470050532. PMID: 9880616
Anthrax pneumonia.
Penn CC, Klotz SA
Semin Respir Infect 1997 Mar;12(1):28-30. PMID: 9097373

Clinical prediction guides

Blunt Traumatic Aortic Injury in the Pan-scan Era.
Yu L, Baumann BM, Raja AS, Mower WR, Langdorf MI, Medak AJ, Anglin DR, Hendey GW, Nishijima D, Rodriguez RM
Acad Emerg Med 2020 Apr;27(4):291-296. Epub 2019 Dec 30 doi: 10.1111/acem.13900. PMID: 31811732
Blunt Trauma: What Is Behind the Widened Mediastinum on Chest X-Ray (CXR)?
Vasileiou G, Qian S, Al-Ghamdi H, Pace D, Rattan R, Mulder M, Namias N, Dante Yeh D
J Surg Res 2019 Nov;243:23-26. Epub 2019 May 28 doi: 10.1016/j.jss.2019.04.079. PMID: 31151033
Clinical Examination for Acute Aortic Dissection: A Systematic Review and Meta-analysis.
Ohle R, Kareemi HK, Wells G, Perry JJ
Acad Emerg Med 2018 Apr;25(4):397-412. Epub 2018 Jan 24 doi: 10.1111/acem.13360. PMID: 29265487
Aortic dissection.
Prisant LM, Nalamolu VR
J Clin Hypertens (Greenwich) 2005 Jun;7(6):367-71. doi: 10.1111/j.1524-6175.2005.04116.x. PMID: 16088302Free PMC Article
Diagnosis and management of blunt great vessel trauma.
von Segesser LK, Fischer A, Vogt P, Turina M
J Card Surg 1997 Mar-Apr;12(2 Suppl):181-6; discussion 186-92. PMID: 9271744

Recent systematic reviews

Misdiagnosis of aortic dissection: A systematic review of the literature.
Lovatt S, Wong CW, Schwarz K, Borovac JA, Lo T, Gunning M, Phan T, Patwala A, Barker D, Mallen CD, Kwok CS
Am J Emerg Med 2022 Mar;53:16-22. Epub 2021 Dec 4 doi: 10.1016/j.ajem.2021.11.047. PMID: 34968970
Clinical Examination for Acute Aortic Dissection: A Systematic Review and Meta-analysis.
Ohle R, Kareemi HK, Wells G, Perry JJ
Acad Emerg Med 2018 Apr;25(4):397-412. Epub 2018 Jan 24 doi: 10.1111/acem.13360. PMID: 29265487

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...