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ovarian failure

MedGen UID:
677092
•Concept ID:
C0747102
•
Disease or Syndrome
Synonym: Ovarian failure
SNOMED CT: Ovarian failure (111550004)

Definition

The inability of the ovaries to function. [from NCI]

Professional guidelines

PubMed

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities.
Fu YX, Ji J, Shan F, Li J, Hu R
Stem Cell Res Ther 2021 Mar 3;12(1):161. doi: 10.1186/s13287-021-02212-0. PMID: 33658073Free PMC Article
Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility.
Esfandyari S, Chugh RM, Park HS, Hobeika E, Ulin M, Al-Hendy A
Cells 2020 Oct 8;9(10) doi: 10.3390/cells9102253. PMID: 33050021Free PMC Article
Immunosuppressive treatment for proliferative lupus nephritis.
Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF
Cochrane Database Syst Rev 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4. PMID: 29957821Free PMC Article

Recent clinical studies

Etiology

Sleep During Menopause.
Hachul H, Hachul de Campos B, Lucena L, Tufik S
Sleep Med Clin 2023 Dec;18(4):423-433. Epub 2023 Jul 16 doi: 10.1016/j.jsmc.2023.06.004. PMID: 38501515
Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence.
Ai G, Meng M, Guo J, Li C, Zhu J, Liu L, Liu B, Yang W, Shao X, Cheng Z, Wang L
Stem Cell Res Ther 2023 Apr 11;14(1):75. doi: 10.1186/s13287-023-03297-5. PMID: 37038203Free PMC Article
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem Cell Res Ther 2020 Feb 4;11(1):49. doi: 10.1186/s13287-019-1537-x. PMID: 32019599Free PMC Article
Down syndrome and infertility: what support should we provide?
Parizot E, Dard R, Janel N, Vialard F
J Assist Reprod Genet 2019 Jun;36(6):1063-1067. Epub 2019 May 9 doi: 10.1007/s10815-019-01457-2. PMID: 31073724Free PMC Article
Premature ovarian failure.
Neumannová H, Müllerová M
Cas Lek Cesk 2018 Dec 3;157(7):350-353. PMID: 30650978

Diagnosis

Role of m6A modification in female infertility and reproductive system diseases.
Chen J, Fang Y, Xu Y, Sun H
Int J Biol Sci 2022;18(9):3592-3604. Epub 2022 May 16 doi: 10.7150/ijbs.69771. PMID: 35813486Free PMC Article
Genetics of human female infertility†.
Yatsenko SA, Rajkovic A
Biol Reprod 2019 Sep 1;101(3):549-566. doi: 10.1093/biolre/ioz084. PMID: 31077289Free PMC Article
Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR.
Pastore LM, Christianson MS, Stelling J, Kearns WG, Segars JH
J Assist Reprod Genet 2018 Jan;35(1):17-23. Epub 2017 Oct 2 doi: 10.1007/s10815-017-1058-4. PMID: 28971280Free PMC Article
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL Jr, Gelber RD, Hortobagyi GN, Albain KS; POEMS/S0230 Investigators
N Engl J Med 2015 Mar 5;372(10):923-32. doi: 10.1056/NEJMoa1413204. PMID: 25738668Free PMC Article
Triple X syndrome: a review of the literature.
Otter M, Schrander-Stumpel CT, Curfs LM
Eur J Hum Genet 2010 Mar;18(3):265-71. Epub 2009 Jul 1 doi: 10.1038/ejhg.2009.109. PMID: 19568271Free PMC Article

Therapy

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence.
Ai G, Meng M, Guo J, Li C, Zhu J, Liu L, Liu B, Yang W, Shao X, Cheng Z, Wang L
Stem Cell Res Ther 2023 Apr 11;14(1):75. doi: 10.1186/s13287-023-03297-5. PMID: 37038203Free PMC Article
Application of Stem Cell Therapy for Infertility.
Saha S, Roy P, Corbitt C, Kakar SS
Cells 2021 Jun 28;10(7) doi: 10.3390/cells10071613. PMID: 34203240Free PMC Article
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem Cell Res Ther 2020 Feb 4;11(1):49. doi: 10.1186/s13287-019-1537-x. PMID: 32019599Free PMC Article
Immunosuppressive treatment for proliferative lupus nephritis.
Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF
Cochrane Database Syst Rev 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4. PMID: 29957821Free PMC Article
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL Jr, Gelber RD, Hortobagyi GN, Albain KS; POEMS/S0230 Investigators
N Engl J Med 2015 Mar 5;372(10):923-32. doi: 10.1056/NEJMoa1413204. PMID: 25738668Free PMC Article

Prognosis

Turner Syndrome and Fertility.
Viuff M, Gravholt CH
Ann Endocrinol (Paris) 2022 Aug;83(4):244-249. Epub 2022 Jun 18 doi: 10.1016/j.ando.2022.06.001. PMID: 35728697
Anti-Müllerian Hormone in Female Reproduction.
di Clemente N, Racine C, Pierre A, Taieb J
Endocr Rev 2021 Nov 16;42(6):753-782. doi: 10.1210/endrev/bnab012. PMID: 33851994
Ovarian Reserve Markers in Premature Ovarian Insufficiency: Within Different Clinical Stages and Different Etiologies.
Jiao X, Meng T, Zhai Y, Zhao L, Luo W, Liu P, Qin Y
Front Endocrinol (Lausanne) 2021;12:601752. Epub 2021 Mar 18 doi: 10.3389/fendo.2021.601752. PMID: 33815272Free PMC Article
Genetics of primary ovarian insufficiency: new developments and opportunities.
Qin Y, Jiao X, Simpson JL, Chen ZJ
Hum Reprod Update 2015 Nov-Dec;21(6):787-808. Epub 2015 Aug 4 doi: 10.1093/humupd/dmv036. PMID: 26243799Free PMC Article
A review of trisomy X (47,XXX).
Tartaglia NR, Howell S, Sutherland A, Wilson R, Wilson L
Orphanet J Rare Dis 2010 May 11;5:8. doi: 10.1186/1750-1172-5-8. PMID: 20459843Free PMC Article

Clinical prediction guides

Management of bone loss due to endocrine therapy during cancer treatment.
Khan MI
Osteoporos Int 2023 Apr;34(4):671-680. Epub 2023 Jan 19 doi: 10.1007/s00198-023-06672-3. PMID: 36656338
Application of Stem Cell Therapy for Infertility.
Saha S, Roy P, Corbitt C, Kakar SS
Cells 2021 Jun 28;10(7) doi: 10.3390/cells10071613. PMID: 34203240Free PMC Article
Anti-Müllerian Hormone in Female Reproduction.
di Clemente N, Racine C, Pierre A, Taieb J
Endocr Rev 2021 Nov 16;42(6):753-782. doi: 10.1210/endrev/bnab012. PMID: 33851994
Ovarian Reserve Markers in Premature Ovarian Insufficiency: Within Different Clinical Stages and Different Etiologies.
Jiao X, Meng T, Zhai Y, Zhao L, Luo W, Liu P, Qin Y
Front Endocrinol (Lausanne) 2021;12:601752. Epub 2021 Mar 18 doi: 10.3389/fendo.2021.601752. PMID: 33815272Free PMC Article
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem Cell Res Ther 2020 Feb 4;11(1):49. doi: 10.1186/s13287-019-1537-x. PMID: 32019599Free PMC Article

Recent systematic reviews

Mesenchymal stem cells therapy improves ovarian function in premature ovarian failure: a systematic review and meta-analysis based on preclinical studies.
Guo C, Ma Y, Situ Y, Liu L, Luo G, Li H, Ma W, Sun L, Wang W, Weng Q, Wu L, Fan D
Front Endocrinol (Lausanne) 2023;14:1165574. Epub 2023 Jul 6 doi: 10.3389/fendo.2023.1165574. PMID: 37484938Free PMC Article
The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis.
Li M, Zhu Y, Wei J, Chen L, Chen S, Lai D
Climacteric 2023 Apr;26(2):95-102. Epub 2022 Dec 15 doi: 10.1080/13697137.2022.2153033. PMID: 36519275
Immunosuppressive treatment for proliferative lupus nephritis.
Tunnicliffe DJ, Palmer SC, Henderson L, Masson P, Craig JC, Tong A, Singh-Grewal D, Flanc RS, Roberts MA, Webster AC, Strippoli GF
Cochrane Database Syst Rev 2018 Jun 29;6(6):CD002922. doi: 10.1002/14651858.CD002922.pub4. PMID: 29957821Free PMC Article
Ovotoxicity of cigarette smoke: A systematic review of the literature.
Budani MC, Tiboni GM
Reprod Toxicol 2017 Sep;72:164-181. Epub 2017 Jul 3 doi: 10.1016/j.reprotox.2017.06.184. PMID: 28684319
Treatment for lupus nephritis.
Henderson L, Masson P, Craig JC, Flanc RS, Roberts MA, Strippoli GF, Webster AC
Cochrane Database Syst Rev 2012 Dec 12;12:CD002922. doi: 10.1002/14651858.CD002922.pub3. PMID: 23235592

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