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Acute lung injury during and following administration of blood product

MedGen UID:
679226
Concept ID:
C0948343
Disease or Syndrome
Synonyms: Acute Lung Injury, Transfusion Related; Acute Lung Injury, Transfusion-Related; TRALI; Transfusion Related Acute Lung Injury; Transfusion-Related Acute Lung Injury
SNOMED CT: TRALI - Transfusion related acute lung injury (733054008); Transfusion related acute lung injury (733054008); Acute lung injury during and following administration of blood product (733054008)

Definition

A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute lung injury during and following administration of blood product

Professional guidelines

PubMed

Yu Y, Lian Z
Front Immunol 2023;14:1175387. Epub 2023 May 12 doi: 10.3389/fimmu.2023.1175387. PMID: 37251400Free PMC Article
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5):428-39. doi: 10.1097/PCC.0000000000000350. PMID: 25647235Free PMC Article

Recent clinical studies

Etiology

O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Roubinian N
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):585-594. Epub 2018 Dec 14 doi: 10.1182/asheducation-2018.1.585. PMID: 30570487Free PMC Article
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article
Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5):428-39. doi: 10.1097/PCC.0000000000000350. PMID: 25647235Free PMC Article
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Diagnosis

Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S
Transfusion 2019 Jul;59(7):2465-2476. Epub 2019 Apr 16 doi: 10.1111/trf.15311. PMID: 30993745Free PMC Article
Semple JW, Rebetz J, Kapur R
Blood 2019 Apr 25;133(17):1840-1853. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-860809. PMID: 30808638
Goel R, Tobian AAR, Shaz BH
Blood 2019 Apr 25;133(17):1831-1839. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-833988. PMID: 30808635
Roubinian N
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):585-594. Epub 2018 Dec 14 doi: 10.1182/asheducation-2018.1.585. PMID: 30570487Free PMC Article
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article

Therapy

O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Semple JW, Rebetz J, Kapur R
Blood 2019 Apr 25;133(17):1840-1853. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-860809. PMID: 30808638
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Sharma S, Sharma P, Tyler LN
Am Fam Physician 2011 Mar 15;83(6):719-24. PMID: 21404983

Prognosis

Yu Y, Lian Z
Front Immunol 2023;14:1175387. Epub 2023 May 12 doi: 10.3389/fimmu.2023.1175387. PMID: 37251400Free PMC Article
Semple JW, Rebetz J, Kapur R
Blood 2019 Apr 25;133(17):1840-1853. Epub 2019 Feb 26 doi: 10.1182/blood-2018-10-860809. PMID: 30808638
Guo Y, Tian X, Wang X, Xiao Z
Front Immunol 2018;9:1299. Epub 2018 Jun 8 doi: 10.3389/fimmu.2018.01299. PMID: 29951056Free PMC Article
Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5):428-39. doi: 10.1097/PCC.0000000000000350. PMID: 25647235Free PMC Article
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Clinical prediction guides

Chen DW, Kang T, Xu XZ, Xia WJ, Ye X, Wu YB, Xu YR, Liu J, Ren H, Deng J, Chen YK, Ding HQ, Aslam M, Zelek WM, Morgan BP, Kapur R, Santoso S, Fu YS
JCI Insight 2023 Mar 22;8(6) doi: 10.1172/jci.insight.165142. PMID: 36809299Free PMC Article
Hu L, Wang B, Jiang Y, Zhu B, Wang C, Yu Q, Hou W, Xia Z, Wu G, Sun Y
Respir Care 2021 Jun;66(6):1029-1038. Epub 2021 Mar 27 doi: 10.4187/respcare.08829. PMID: 33774597
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Sperry JL, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ, Adams PW, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Duane TM, Alarcon LH, Callaway CW, Zuckerbraun BS, Neal MD, Rosengart MR, Forsythe RM, Billiar TR, Yealy DM, Peitzman AB, Zenati MS; PAMPer Study Group
N Engl J Med 2018 Jul 26;379(4):315-326. doi: 10.1056/NEJMoa1802345. PMID: 30044935
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Recent systematic reviews

White SK, Walker BS, Schmidt RL, Metcalf RA
Transfusion 2024 Feb;64(2):289-300. Epub 2023 Dec 20 doi: 10.1111/trf.17688. PMID: 38116828
Chen BZ, Xia R
Vox Sang 2020 Jul;115(5):349-357. Epub 2020 Apr 15 doi: 10.1111/vox.12879. PMID: 32293034
Chassé M, McIntyre L, English SW, Tinmouth A, Knoll G, Wolfe D, Wilson K, Shehata N, Forster A, van Walraven C, Fergusson DA
Transfus Med Rev 2016 Apr;30(2):69-80. Epub 2016 Feb 9 doi: 10.1016/j.tmrv.2016.01.002. PMID: 26920039
Martí-Carvajal AJ, Simancas-Racines D, Peña-González BS
Cochrane Database Syst Rev 2015 Jul 14;2015(7):CD009330. doi: 10.1002/14651858.CD009330.pub2. PMID: 26171902Free PMC Article
Middelburg RA, van Stein D, Briët E, van der Bom JG
Transfusion 2008 Oct;48(10):2167-76. Epub 2008 Jun 28 doi: 10.1111/j.1537-2995.2008.01810.x. PMID: 18564387

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