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Mouth Mucous Membrane Leukoplakia

MedGen UID:: 68702
•Concept ID:: C0240371
•: Finding

Definition

A clinical term that indicates the presence of a white patch on the mucous membrane in the mouth which cannot be characterized as any other disease. It may be a precancerous condition and in most cases histologic examination reveals keratosis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMouth Mucous Membrane Leukoplakia

Pathological Conditions, Signs and Symptoms
- Pathological Conditions, Anatomical
  - Leukoplakia
    - Mucous Membrane Leukoplakia
      - Mouth Mucous Membrane Leukoplakia
        Leukoplakia of Buccal Mucosa

Professional guidelines

PubMed

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review.

Parakh MK, Ulaganambi S, Ashifa N, Premkumar R, Jain AL
Eur J Cancer Prev 2020 Jan;29(1):65-72. doi: 10.1097/CEJ.0000000000000510. PMID: 30921006

See all (32)

Recent clinical studies

Etiology

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Lorenzo-Pouso AI, Lafuente-Ibáñez de Mendoza I, Pérez-Sayáns M, Pérez-Jardón A, Chamorro-Petronacci CM, Blanco-Carrión A, Aguirre-Urízar JM
J Oral Pathol Med 2022 Aug;51(7):585-593. Epub 2022 May 12 doi: 10.1111/jop.13304. PMID: 35488780 Free PMC Article

Common Oral Lesions.

Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

See all (431)

Diagnosis

Common Oral Lesions.

Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.

Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762 Free PMC Article

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

See all (416)

Therapy

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions.

Gutkind JS, Molinolo AA, Wu X, Wang Z, Nachmanson D, Harismendy O, Alexandrov LB, Wuertz BR, Ondrey FG, Laronde D, Rock LD, Rosin M, Coffey C, Butler VD, Bengtson L, Hsu CH, Bauman JE, Hewitt SM, Cohen EE, Chow HS, Lippman SM, Szabo E
JCI Insight 2021 Sep 8;6(17) doi: 10.1172/jci.insight.147096. PMID: 34255745 Free PMC Article

Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.

Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762 Free PMC Article

Systemic and topical photodynamic therapy (PDT) on oral mucosa lesions: an overview.

Di Stasio D, Romano A, Gentile C, Maio C, Lucchese A, Serpico R, Paparella R, Minervini G, Candotto V, Laino L
J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):123-126. PMID: 29460529

Contact and irritant stomatitis.

Tosti A, Piraccini BM, Peluso AM
Semin Cutan Med Surg 1997 Dec;16(4):314-9. doi: 10.1016/s1085-5629(97)80022-3. PMID: 9421224

See all (238)

Prognosis

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Oral erythroplakia-What is it?

Holmstrup P
Oral Dis 2018 Mar;24(1-2):138-143. doi: 10.1111/odi.12709. PMID: 29480616

Erythroplakia: the dangerous red mucosa.

Bouquot JE, Ephros H
Pract Periodontics Aesthet Dent 1995 Aug;7(6):59-67; quiz 68. PMID: 9002888

See all (213)

Clinical prediction guides

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Common Oral Lesions.

Randall DA, Wilson Westmark NL, Neville BW
Am Fam Physician 2022 Apr 1;105(4):369-376. PMID: 35426641

Epithelial and fibroblast SPARC expression patterns in oral leukoplakia and oral squamous cell carcinoma.

Poomsawat S, Kosanwat T, Meesakul O, Sanguansin S
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Aug;134(2):e44-e50. Epub 2021 Oct 31 doi: 10.1016/j.oooo.2021.10.019. PMID: 35165061

Management of oral potentially malignant disorders.

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758

Aneuploidy and loss of heterozygosity as risk markers for malignant transformation in oral mucosa.

Odell EW
Oral Dis 2021 Nov;27(8):1993-2007. Epub 2021 Feb 26 doi: 10.1111/odi.13797. PMID: 33577101

See all (309)

Recent systematic reviews

Oral bacteriome and oral potentially malignant disorders: A systematic review of the associations.

Pignatelli P, Curia MC, Tenore G, Bondi D, Piattelli A, Romeo U
Arch Oral Biol 2024 Apr;160:105891. Epub 2024 Jan 8 doi: 10.1016/j.archoralbio.2024.105891. PMID: 38295615

Critical update, systematic review, and meta-analysis of oral erythroplakia as an oral potentially malignant disorder.

Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review.

Torrejon-Moya A, Jané-Salas E, López-López J
J Oral Pathol Med 2020 May;49(5):404-408. Epub 2020 Feb 9 doi: 10.1111/jop.12999. PMID: 31990082

Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.

Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Malignant transformation of oral leukoplakia: a systematic review of observational studies.

Warnakulasuriya S, Ariyawardana A
J Oral Pathol Med 2016 Mar;45(3):155-66. Epub 2015 Jul 20 doi: 10.1111/jop.12339. PMID: 26189354

See all (11)