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Fungal keratitis

MedGen UID:
687913
Concept ID:
C1262117
Disease or Syndrome
Synonyms: Fungal infection of cornea; Fungal Keratitis; fungal keratitis; Keratomycosis; Mycotic keratitis
SNOMED CT: Mycotic keratitis (314558005); Fungal infection of cornea (314558005); Keratomycosis (314558005); Fungal keratitis (314558005)
 
Monarch Initiative: MONDO:0033821
Orphanet: ORPHA519930

Definition

A rare disorder of the anterior segment of the eye characterized by ocular infection by human-pathogenic fungi, most commonly <i>Aspergillus</i>, <i>Candida</i>, or <i>Fusarium</i> species, which gain access into the corneal stroma through a defect in the corneal epithelium. Risk factors include trauma, ocular surface disease, contact lenses, or immunocompromised state. Patients present with pain, foreign body sensation, redness, photophobia, tearing, secretion, or blurred vision. The condition may be complicated by corneal destruction and perforation, endophthalmitis, scleritis, and panophthalmitis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFungal keratitis

Professional guidelines

PubMed

Sharma N, Bagga B, Singhal D, Nagpal R, Kate A, Saluja G, Maharana PK
Ocul Surf 2022 Apr;24:22-30. Epub 2021 Dec 13 doi: 10.1016/j.jtos.2021.12.001. PMID: 34915188
Donovan C, Arenas E, Ayyala RS, Margo CE, Espana EM
Surv Ophthalmol 2022 May-Jun;67(3):758-769. Epub 2021 Aug 20 doi: 10.1016/j.survophthal.2021.08.002. PMID: 34425126Free PMC Article
Sha XY, Shi Q, Liu L, Zhong JX
Int Ophthalmol 2021 Sep;41(9):3249-3256. Epub 2021 Apr 30 doi: 10.1007/s10792-021-01873-3. PMID: 33929644

Recent clinical studies

Etiology

Niu L, Liu X, Ma Z, Yin Y, Sun L, Yang L, Zheng Y
Microb Pathog 2020 Jan;138:103802. Epub 2019 Oct 15 doi: 10.1016/j.micpath.2019.103802. PMID: 31626916
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448
Nucci F, Nouér SA, Capone D, Anaissie E, Nucci M
Semin Respir Crit Care Med 2015 Oct;36(5):706-14. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562897. PMID: 26398537
Thomas PA, Geraldine P
Curr Opin Infect Dis 2007 Apr;20(2):129-41. doi: 10.1097/QCO.0b013e328017f878. PMID: 17496570
Fernandez V, Dursun D, Miller D, Alfonso EC
Am J Ophthalmol 2002 Sep;134(3):435-8. doi: 10.1016/s0002-9394(02)01576-3. PMID: 12208257

Diagnosis

Cabrera-Aguas M, Khoo P, Watson SL
Clin Exp Ophthalmol 2022 Jul;50(5):543-562. Epub 2022 Jun 3 doi: 10.1111/ceo.14113. PMID: 35610943Free PMC Article
Sharma N, Bagga B, Singhal D, Nagpal R, Kate A, Saluja G, Maharana PK
Ocul Surf 2022 Apr;24:22-30. Epub 2021 Dec 13 doi: 10.1016/j.jtos.2021.12.001. PMID: 34915188
Donovan C, Arenas E, Ayyala RS, Margo CE, Espana EM
Surv Ophthalmol 2022 May-Jun;67(3):758-769. Epub 2021 Aug 20 doi: 10.1016/j.survophthal.2021.08.002. PMID: 34425126Free PMC Article
Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J
Surv Ophthalmol 2019 May-Jun;64(3):255-271. Epub 2018 Dec 24 doi: 10.1016/j.survophthal.2018.12.003. PMID: 30590103Free PMC Article
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448

Therapy

Sharma N, Bagga B, Singhal D, Nagpal R, Kate A, Saluja G, Maharana PK
Ocul Surf 2022 Apr;24:22-30. Epub 2021 Dec 13 doi: 10.1016/j.jtos.2021.12.001. PMID: 34915188
Donovan C, Arenas E, Ayyala RS, Margo CE, Espana EM
Surv Ophthalmol 2022 May-Jun;67(3):758-769. Epub 2021 Aug 20 doi: 10.1016/j.survophthal.2021.08.002. PMID: 34425126Free PMC Article
Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J
Surv Ophthalmol 2019 May-Jun;64(3):255-271. Epub 2018 Dec 24 doi: 10.1016/j.survophthal.2018.12.003. PMID: 30590103Free PMC Article
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448
Nucci F, Nouér SA, Capone D, Anaissie E, Nucci M
Semin Respir Crit Care Med 2015 Oct;36(5):706-14. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562897. PMID: 26398537

Prognosis

Niu L, Liu X, Ma Z, Yin Y, Sun L, Yang L, Zheng Y
Microb Pathog 2020 Jan;138:103802. Epub 2019 Oct 15 doi: 10.1016/j.micpath.2019.103802. PMID: 31626916
Sahay P, Singhal D, Nagpal R, Maharana PK, Farid M, Gelman R, Sinha R, Agarwal T, Titiyal JS, Sharma N
Surv Ophthalmol 2019 May-Jun;64(3):380-400. Epub 2019 Feb 22 doi: 10.1016/j.survophthal.2019.02.007. PMID: 30797882
Bourcier T, Sauer A, Dory A, Denis J, Sabou M
J Fr Ophtalmol 2017 Nov;40(9):e307-e313. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.08.001. PMID: 28987448
Srinivasan M
Curr Opin Ophthalmol 2004 Aug;15(4):321-7. doi: 10.1097/00055735-200408000-00008. PMID: 15232472
Fernandez V, Dursun D, Miller D, Alfonso EC
Am J Ophthalmol 2002 Sep;134(3):435-8. doi: 10.1016/s0002-9394(02)01576-3. PMID: 12208257

Clinical prediction guides

Keenan JD
Cornea 2023 Nov 1;42(11):1333-1339. Epub 2023 Jul 4 doi: 10.1097/ICO.0000000000003340. PMID: 38112645Free PMC Article
Harbiyeli İİ, Erdem E, Görkemli N, İbayev A, Kandemir H, Açıkalın A, İlkit M, Yağmur M
Turk J Ophthalmol 2022 Apr 28;52(2):75-85. doi: 10.4274/tjo.galenos.2021.09515. PMID: 35481727Free PMC Article
Huang Q, Zhang W, Sun Y, Li X, Zhang X, Lu X, Qi X
Mycopathologia 2022 Feb;187(1):95-102. Epub 2021 Nov 17 doi: 10.1007/s11046-021-00604-7. PMID: 34787839
Brown L, Leck AK, Gichangi M, Burton MJ, Denning DW
Lancet Infect Dis 2021 Mar;21(3):e49-e57. Epub 2020 Oct 22 doi: 10.1016/S1473-3099(20)30448-5. PMID: 33645500
Fernandez V, Dursun D, Miller D, Alfonso EC
Am J Ophthalmol 2002 Sep;134(3):435-8. doi: 10.1016/s0002-9394(02)01576-3. PMID: 12208257

Recent systematic reviews

Ahmadikia K, Aghaei Gharehbolagh S, Fallah B, Naeimi Eshkaleti M, Malekifar P, Rahsepar S, Getso MI, Sharma S, Mahmoudi S
Front Cell Infect Microbiol 2021;11:698780. Epub 2021 Aug 26 doi: 10.3389/fcimb.2021.698780. PMID: 34513726Free PMC Article
Ting DSJ, Henein C, Said DG, Dua HS
Sci Rep 2021 Jun 21;11(1):13007. doi: 10.1038/s41598-021-92366-x. PMID: 34155280Free PMC Article
Shivaji S
Indian J Ophthalmol 2021 Mar;69(3):535-542. doi: 10.4103/ijo.IJO_1362_20. PMID: 33595467Free PMC Article
Papaioannou L, Miligkos M, Papathanassiou M
Cornea 2016 Jan;35(1):62-71. doi: 10.1097/ICO.0000000000000644. PMID: 26509768
FlorCruz NV, Peczon IV, Evans JR
Cochrane Database Syst Rev 2012 Feb 15;(2):CD004241. doi: 10.1002/14651858.CD004241.pub3. PMID: 22336802

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