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Skin Lymphoepithelioma-Like Carcinoma

MedGen UID:
699346
•Concept ID:
C1276137
•
Neoplastic Process
Synonyms: Lymphoepithelial tumor of skin; Lymphoepithelioma-like carcinoma of skin
SNOMED CT: Lymphoepithelial tumor of skin (403952004); Lymphoepithelioma-like carcinoma of skin (403952004)

Definition

A rare, poorly differentiated squamous cell carcinoma of the skin. It is characterized by the presence of tumor cells islands surrounded and infiltrated by lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Lymphoepithelioma-Like Carcinoma

Professional guidelines

PubMed

Melanotic and non-melanotic malignancies of the face and external ear - A review of current treatment concepts and future options.
Kolk A, Wolff KD, Smeets R, Kesting M, Hein R, Eckert AW
Cancer Treat Rev 2014 Aug;40(7):819-37. Epub 2014 Apr 16 doi: 10.1016/j.ctrv.2014.04.002. PMID: 24814015

Recent clinical studies

Etiology

Lymphoepithelioma-like carcinoma of the skin.
Cavalieri S, Feliciani C, Massi G, Addolorato G, Gasbarrini G, Amerio P, Rotoli M
Int J Immunopathol Pharmacol 2007 Oct-Dec;20(4):851-4. doi: 10.1177/039463200702000424. PMID: 18179760
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Apr;33(4):261-79. doi: 10.1111/j.0303-6987.2006.00516.x. PMID: 16630176
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Mar;33(3):191-206. doi: 10.1111/j.0303-6987.2006.00516_1.x. PMID: 16466506
Cutaneous lymphadenoma.
Inalöz HS, Chowdhury MM, Knight AG
J Eur Acad Dermatol Venereol 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x. PMID: 11763398
Cutaneous lymphoepithelial neoplasms.
Okamura JM, Barr RJ
Adv Dermatol 1997;12:277-94; discussion 295. PMID: 8973744

Diagnosis

Lymphoepithelioma-like carcinoma of the skin.
Oliveira CC, Nóbrega VC, Marques MEA
An Bras Dermatol 2018 Mar;93(2):256-258. doi: 10.1590/abd1806-4841.20187205. PMID: 29723365Free PMC Article
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
Wick MR, Santa Cruz DJ, Gru AA
Semin Diagn Pathol 2017 Jan;34(1):99-107. Epub 2016 Nov 29 doi: 10.1053/j.semdp.2016.11.008. PMID: 27979335
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature.
Welch PQ, Williams SB, Foss RD, Tomaszewski MM, Gupta A, Ojha J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Jan;111(1):78-86. Epub 2010 Oct 16 doi: 10.1016/j.tripleo.2010.05.075. PMID: 20952226
Lymphoepithelioma-like carcinoma of the skin.
Cavalieri S, Feliciani C, Massi G, Addolorato G, Gasbarrini G, Amerio P, Rotoli M
Int J Immunopathol Pharmacol 2007 Oct-Dec;20(4):851-4. doi: 10.1177/039463200702000424. PMID: 18179760
Cutaneous lymphadenoma.
Inalöz HS, Chowdhury MM, Knight AG
J Eur Acad Dermatol Venereol 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x. PMID: 11763398

Therapy

Lymphoepithelioma-Like Carcinoma of the Esophagus: A Rare Tumor.
Khokhar N, Nasir H, Amir M, Hassan S, Khan K, Ahmed M
J Coll Physicians Surg Pak 2017 Sep;27(9):S114-S116. PMID: 28969745

Prognosis

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a recurrent and metastatic case.
Mucha-Małecka A, Urbanek K, Ambicka A, Majchrzak P, Małecki K
Strahlenther Onkol 2019 Nov;195(11):1028-1032. Epub 2019 Sep 9 doi: 10.1007/s00066-019-01516-8. PMID: 31501980Free PMC Article
Melanotic and non-melanotic malignancies of the face and external ear - A review of current treatment concepts and future options.
Kolk A, Wolff KD, Smeets R, Kesting M, Hein R, Eckert AW
Cancer Treat Rev 2014 Aug;40(7):819-37. Epub 2014 Apr 16 doi: 10.1016/j.ctrv.2014.04.002. PMID: 24814015
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Apr;33(4):261-79. doi: 10.1111/j.0303-6987.2006.00516.x. PMID: 16630176
Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
Cassarino DS, Derienzo DP, Barr RJ
J Cutan Pathol 2006 Mar;33(3):191-206. doi: 10.1111/j.0303-6987.2006.00516_1.x. PMID: 16466506
Lymphoepithelioma-like carcinoma of the skin: a report of 3 Epstein-Barr virus (EBV)-negative additional cases. Immunohistochemical study of the stroma reaction.
Ferlicot S, Plantier F, Rethers L, Bui AD, Wechsler J
J Cutan Pathol 2000 Jul;27(6):306-11. doi: 10.1034/j.1600-0560.2000.027006306.x. PMID: 10885408

Clinical prediction guides

Primary lymphoepithelioma-like carcinoma of the lung.
Bildirici K, Ak G, Peker B, Metintaş M, Alataş F, Erginel S, Uçgun I
Tuberk Toraks 2005;53(1):69-73. PMID: 15765291
Neuroendocrine carcinoma of the skin with lymphoepithelioma-like features.
Rosso R, Paulli M, Carnevali L
Am J Dermatopathol 1998 Oct;20(5):483-6. doi: 10.1097/00000372-199810000-00010. PMID: 9790110
Lymphoepithelioma-like carcinoma of the skin.
Ko T, Muramatsu T, Shirai T
J Dermatol 1997 Feb;24(2):104-9. doi: 10.1111/j.1346-8138.1997.tb02752.x. PMID: 9065705
Lymphoepithelioma-like carcinoma of the skin.
Shek TW, Leung EY, Luk IS, Loong F, Chan AC, Yik YH, Lam LK
Am J Dermatopathol 1996 Dec;18(6):637-44. doi: 10.1097/00000372-199612000-00017. PMID: 8989941

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