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Secondary Raynaud phenomenon

MedGen UID:
705755
•Concept ID:
C1282916
•
Disease or Syndrome
Synonyms: Raynaud's Syndrome; Secondary Raynaud Phenomenon; Secondary Raynaud's Phenomenon; Secondary Raynaud's phenomenon
SNOMED CT: Secondary Raynaud phenomenon (356198000); Secondary Raynaud's phenomenon (356198000)

Definition

Raynaud phenomenon associated with an underlying autoimmune disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Raynaud phenomenon

Professional guidelines

PubMed

Therapy. Optimized treatment algorithms for digital vasculopathy in SSc.
Cutolo M, Sulli A
Nat Rev Rheumatol 2015 Oct;11(10):569-71. Epub 2015 Aug 11 doi: 10.1038/nrrheum.2015.111. PMID: 26260763
Assessing microvascular changes in systemic sclerosis diagnosis and management.
Cutolo M, Sulli A, Smith V
Nat Rev Rheumatol 2010 Oct;6(10):578-87. Epub 2010 Aug 10 doi: 10.1038/nrrheum.2010.104. PMID: 20703220

Recent clinical studies

Etiology

Raynaud Phenomenon and Other Vasospastic Disorders.
Casanegra AI, Shepherd RF
Cardiol Clin 2021 Nov;39(4):583-599. doi: 10.1016/j.ccl.2021.06.010. PMID: 34686269
Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy.
Boukovalas S, Mays AC, Selber JC
Ann Plast Surg 2019 Jan;82(1):53-54. doi: 10.1097/SAP.0000000000001622. PMID: 30260839
Prevalence of Raynaud phenomenon and nailfold capillaroscopic abnormalities in Fabry disease: a cross-sectional study.
Deshayes S, Auboire L, Jaussaud R, Lidove O, Parienti JJ, Triclin N, Imbert B, Bienvenu B, Aouba A
Medicine (Baltimore) 2015 May;94(20):e780. doi: 10.1097/MD.0000000000000780. PMID: 25997047Free PMC Article
Assessing microvascular changes in systemic sclerosis diagnosis and management.
Cutolo M, Sulli A, Smith V
Nat Rev Rheumatol 2010 Oct;6(10):578-87. Epub 2010 Aug 10 doi: 10.1038/nrrheum.2010.104. PMID: 20703220
Calcium antagonists in dermatology: a review of the evidence and research-based studies.
Palamaras I, Kyriakis K
Dermatol Online J 2005 Aug 1;11(2):8. PMID: 16150216

Diagnosis

Raynaud Phenomenon and Other Vasospastic Disorders.
Casanegra AI, Shepherd RF
Cardiol Clin 2021 Nov;39(4):583-599. doi: 10.1016/j.ccl.2021.06.010. PMID: 34686269
Hand-arm vibration syndrome: What family physicians should know.
Shen SC, House RA
Can Fam Physician 2017 Mar;63(3):206-210. PMID: 28292796Free PMC Article
Dynamic Doppler evaluation of the hand arteries to distinguish between primary and secondary raynaud phenomenon.
Toprak U, Hayretci M, Erhuner Z, Tascilar K, Ates A, Karaaslan Y, Karademir MA
AJR Am J Roentgenol 2011 Jul;197(1):W175-80. doi: 10.2214/AJR.10.5740. PMID: 21700982
Assessing microvascular changes in systemic sclerosis diagnosis and management.
Cutolo M, Sulli A, Smith V
Nat Rev Rheumatol 2010 Oct;6(10):578-87. Epub 2010 Aug 10 doi: 10.1038/nrrheum.2010.104. PMID: 20703220
Raynaud phenomenon.
Reilly A, Snyder B
Am J Nurs 2005 Aug;105(8):56-65; quiz 65-6. doi: 10.1097/00000446-200508000-00028. PMID: 16062060

Therapy

Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy.
Boukovalas S, Mays AC, Selber JC
Ann Plast Surg 2019 Jan;82(1):53-54. doi: 10.1097/SAP.0000000000001622. PMID: 30260839
Interferons beta have vasoconstrictive and procoagulant effects: a woman who developed livedo reticularis and Raynaud phenomenon in association with interferon beta treatment for multiple sclerosis.
Rot U, Ledinek AH
Clin Neurol Neurosurg 2013 Dec;115 Suppl 1:S79-81. doi: 10.1016/j.clineuro.2013.09.027. PMID: 24321162
Assessing microvascular changes in systemic sclerosis diagnosis and management.
Cutolo M, Sulli A, Smith V
Nat Rev Rheumatol 2010 Oct;6(10):578-87. Epub 2010 Aug 10 doi: 10.1038/nrrheum.2010.104. PMID: 20703220
Calcium antagonists in dermatology: a review of the evidence and research-based studies.
Palamaras I, Kyriakis K
Dermatol Online J 2005 Aug 1;11(2):8. PMID: 16150216
Is there a vasospasmolytic effect of acupuncture in patients with secondary Raynaud phenomenon?
Hahn M, Steins A, Möhrle M, Blum A, Jünger M
J Dtsch Dermatol Ges 2004 Sep;2(9):758-62. doi: 10.1046/j.1439-0353.2004.04729.x. PMID: 16279219

Prognosis

Raynaud Phenomenon and Other Vasospastic Disorders.
Casanegra AI, Shepherd RF
Cardiol Clin 2021 Nov;39(4):583-599. doi: 10.1016/j.ccl.2021.06.010. PMID: 34686269
Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy.
Boukovalas S, Mays AC, Selber JC
Ann Plast Surg 2019 Jan;82(1):53-54. doi: 10.1097/SAP.0000000000001622. PMID: 30260839
Hand-arm vibration syndrome: What family physicians should know.
Shen SC, House RA
Can Fam Physician 2017 Mar;63(3):206-210. PMID: 28292796Free PMC Article
Quantitative Alterations of Capillary Diameter Have a Predictive Value for Development of the Capillaroscopic Systemic Sclerosis Pattern.
Trombetta AC, Smith V, Pizzorni C, Meroni M, Paolino S, Cariti C, Ruaro B, Sulli A, Cutolo M
J Rheumatol 2016 Mar;43(3):599-606. Epub 2016 Feb 1 doi: 10.3899/jrheum.150900. PMID: 26834221
Assessing microvascular changes in systemic sclerosis diagnosis and management.
Cutolo M, Sulli A, Smith V
Nat Rev Rheumatol 2010 Oct;6(10):578-87. Epub 2010 Aug 10 doi: 10.1038/nrrheum.2010.104. PMID: 20703220

Clinical prediction guides

Endothelial dysfunction, microvascular damage and ischemic peripheral vasculopathy in systemic sclerosis.
Silva I, Teixeira A, Oliveira J, Almeida R, Vasconcelos C
Clin Hemorheol Microcirc 2017;66(2):117-130. doi: 10.3233/CH-150044. PMID: 28128745
Quantitative Alterations of Capillary Diameter Have a Predictive Value for Development of the Capillaroscopic Systemic Sclerosis Pattern.
Trombetta AC, Smith V, Pizzorni C, Meroni M, Paolino S, Cariti C, Ruaro B, Sulli A, Cutolo M
J Rheumatol 2016 Mar;43(3):599-606. Epub 2016 Feb 1 doi: 10.3899/jrheum.150900. PMID: 26834221
Prevalence of Raynaud phenomenon and nailfold capillaroscopic abnormalities in Fabry disease: a cross-sectional study.
Deshayes S, Auboire L, Jaussaud R, Lidove O, Parienti JJ, Triclin N, Imbert B, Bienvenu B, Aouba A
Medicine (Baltimore) 2015 May;94(20):e780. doi: 10.1097/MD.0000000000000780. PMID: 25997047Free PMC Article
Long-term follow-up of hypothenar hammer syndrome: a series of 47 patients.
Marie I, Hervé F, Primard E, Cailleux N, Levesque H
Medicine (Baltimore) 2007 Nov;86(6):334-343. doi: 10.1097/MD.0b013e31815c95d3. PMID: 18004178
Correlations among capillaroscopic abnormalities, digital flow and immunologic findings in patients with isolated Raynaud's phenomenon. Can laser Doppler flowmetry help identify a secondary Raynaud phenomenon?
Binaghi F, Cannas F, Mathieu A, Pitzus F
Int Angiol 1992 Jul-Sep;11(3):186-94. PMID: 1460352

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