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Legionella infection

MedGen UID:
7292
•Concept ID:
C0023240
•
Disease or Syndrome
Synonym: Legionellosis
SNOMED CT: Legionella infection (26726000); Legionellosis (26726000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Related gene: TLR5
 
Monarch Initiative: MONDO:0005823
Orphanet: ORPHA549

Definition

Legionellosis or Legionnaires' disease (LD) is a bacterial lung infection characterized by a potentially fatal pneumonia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Quantitative Microbial Risk Assessment Applied to Legionella Contamination on Long-Distance Public Transport.
Federigi I, De Giglio O, Diella G, Triggiano F, Apollonio F, D'Ambrosio M, Cioni L, Verani M, Montagna MT, Carducci A
Int J Environ Res Public Health 2022 Feb 10;19(4) doi: 10.3390/ijerph19041960. PMID: 35206148Free PMC Article
New trends in the prevention and management of community-acquired pneumonia.
Postma DF, van Werkhoven CH, Huijts SM, Bolkenbaas M, Oosterheert JJ, Bonten MJ
Neth J Med 2012 Oct;70(8):337-48. PMID: 23065981
Treatment strategies for Legionella infection.
Pedro-Botet ML, Yu VL
Expert Opin Pharmacother 2009 May;10(7):1109-21. doi: 10.1517/14656560902900820. PMID: 19405787

Recent clinical studies

Etiology

Incidence and influence of hyperCKemia in Legionella infection.
Hill J, Li J, Li Y
J Neurol Sci 2022 May 15;436:120252. Epub 2022 Apr 6 doi: 10.1016/j.jns.2022.120252. PMID: 35405618
Significance of Hypophosphatemia in Patients with Pneumonia.
Morimoto Y, Ishiguro T, Uozumi R, Takano K, Kobayashi Y, Kobayashi Y, Shimizu Y, Takayanagi N
Intern Med 2022;61(7):979-988. Epub 2022 Apr 1 doi: 10.2169/internalmedicine.6949-20. PMID: 35370255Free PMC Article
Overview and comparison of Legionella regulations worldwide.
Van Kenhove E, Dinne K, Janssens A, Laverge J
Am J Infect Control 2019 Aug;47(8):968-978. Epub 2019 Jan 9 doi: 10.1016/j.ajic.2018.10.006. PMID: 30638676
Legionnaire's Disease and Immunosuppressive Drugs.
Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686
Legionella infection.
Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Diagnosis

Incidence and influence of hyperCKemia in Legionella infection.
Hill J, Li J, Li Y
J Neurol Sci 2022 May 15;436:120252. Epub 2022 Apr 6 doi: 10.1016/j.jns.2022.120252. PMID: 35405618
Could it be Legionella?
Darby J, Buising K
Aust Fam Physician 2008 Oct;37(10):812-5. PMID: 19002299
Legionellosis.
Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431
Legionella infection.
Murray S
CMAJ 2005 Nov 22;173(11):1322. doi: 10.1503/cmaj.051349. PMID: 16301697Free PMC Article
Legionella infection.
Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Therapy

Legionnaire's Disease and Immunosuppressive Drugs.
Htwe TH, Khardori NM
Infect Dis Clin North Am 2017 Mar;31(1):29-42. Epub 2016 Dec 12 doi: 10.1016/j.idc.2016.10.003. PMID: 27979686
Treatment strategies for Legionella infection.
Pedro-Botet ML, Yu VL
Expert Opin Pharmacother 2009 May;10(7):1109-21. doi: 10.1517/14656560902900820. PMID: 19405787
Legionellosis.
Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431
Legionella infection and control in occupational and environmental health.
Fujii J, Yoshida S
Rev Environ Health 1998 Oct-Dec;13(4):179-203. doi: 10.1515/reveh.1998.13.4.179. PMID: 9987814
Legionella infection.
Nguyen ML, Yu VL
Clin Chest Med 1991 Jun;12(2):257-68. PMID: 1855370

Prognosis

Incidence and influence of hyperCKemia in Legionella infection.
Hill J, Li J, Li Y
J Neurol Sci 2022 May 15;436:120252. Epub 2022 Apr 6 doi: 10.1016/j.jns.2022.120252. PMID: 35405618
Significance of Hypophosphatemia in Patients with Pneumonia.
Morimoto Y, Ishiguro T, Uozumi R, Takano K, Kobayashi Y, Kobayashi Y, Shimizu Y, Takayanagi N
Intern Med 2022;61(7):979-988. Epub 2022 Apr 1 doi: 10.2169/internalmedicine.6949-20. PMID: 35370255Free PMC Article
Legionnaire's Disease and Influenza.
Magira EE, Zakynthinos S
Infect Dis Clin North Am 2017 Mar;31(1):137-153. doi: 10.1016/j.idc.2016.10.010. PMID: 28159173
Atypical presentation of Legionella pneumonia among patients with underlying cancer: A fifteen-year review.
del Castillo M, Lucca A, Plodkowski A, Huang YT, Kaplan J, Gilhuley K, Babady NE, Seo SK, Kamboj M
J Infect 2016 Jan;72(1):45-51. Epub 2015 Oct 20 doi: 10.1016/j.jinf.2015.10.006. PMID: 26496794Free PMC Article
Legionella prosthetic-valve endocarditis.
Tompkins LS, Roessler BJ, Redd SC, Markowitz LE, Cohen ML
N Engl J Med 1988 Mar 3;318(9):530-5. doi: 10.1056/NEJM198803033180902. PMID: 3340136

Clinical prediction guides

Significance of Hypophosphatemia in Patients with Pneumonia.
Morimoto Y, Ishiguro T, Uozumi R, Takano K, Kobayashi Y, Kobayashi Y, Shimizu Y, Takayanagi N
Intern Med 2022;61(7):979-988. Epub 2022 Apr 1 doi: 10.2169/internalmedicine.6949-20. PMID: 35370255Free PMC Article
Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies.
Graham FF, Finn N, White P, Hales S, Baker MG
Int J Environ Res Public Health 2022 Feb 8;19(3) doi: 10.3390/ijerph19031907. PMID: 35162928Free PMC Article
Symbiont-Mediated Defense against Legionella pneumophila in Amoebae.
König L, Wentrup C, Schulz F, Wascher F, Escola S, Swanson MS, Buchrieser C, Horn M
mBio 2019 May 14;10(3) doi: 10.1128/mBio.00333-19. PMID: 31088922Free PMC Article
Overview and comparison of Legionella regulations worldwide.
Van Kenhove E, Dinne K, Janssens A, Laverge J
Am J Infect Control 2019 Aug;47(8):968-978. Epub 2019 Jan 9 doi: 10.1016/j.ajic.2018.10.006. PMID: 30638676
Legionellosis.
Pedro-Botet ML, Sabrià M
Semin Respir Crit Care Med 2005 Dec;26(6):625-34. doi: 10.1055/s-2005-925526. PMID: 16388431

Recent systematic reviews

Can legionellosis be considered an occupational risk in the healthcare sector? A systematic review and meta-analysis.
Bongiovanni A, Colazingari V, Messineo A, Del Cimmuto A, De Giusti M, La Torre G
Public Health 2023 Jan;214:31-37. Epub 2022 Dec 1 doi: 10.1016/j.puhe.2022.10.027. PMID: 36463752
Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies.
Graham FF, Finn N, White P, Hales S, Baker MG
Int J Environ Res Public Health 2022 Feb 8;19(3) doi: 10.3390/ijerph19031907. PMID: 35162928Free PMC Article
Accuracy of diagnostic tests for Legionnaires' disease: a systematic review.
Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T
J Med Microbiol 2017 Apr;66(4):485-489. doi: 10.1099/jmm.0.000454. PMID: 28463665

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