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Lichen sclerosus et atrophicus(LSA)

MedGen UID:
7338
Concept ID:
C0023652
Disease or Syndrome
Synonyms: Lichen sclerosis; Lichen sclerosis et atrophicus; Lichen sclerosus; LSA
SNOMED CT: Lichen sclerosus (895217008); Lichen sclerosus (895454001)
 
Monarch Initiative: MONDO:0007899
OMIM®: 151590
Orphanet: ORPHA33409

Definition

A chronic inflammatory process affecting the skin. It is characterized by the presence of white, indurated plaques, epidermal atrophy, and fibrosis of the upper dermis. It usually appears in the vulva and penis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLichen sclerosus et atrophicus

Professional guidelines

PubMed

Manuelpillai N, Saunders H, Veysey E
Australas J Dermatol 2022 May;63(2):248-250. Epub 2022 Mar 9 doi: 10.1111/ajd.13814. PMID: 35262179
Rodríguez-Salgado P, García-Romero MT
Gac Med Mex 2019;155(5):483-491. doi: 10.24875/GMM.M20000336. PMID: 32091025
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159

Recent clinical studies

Etiology

Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Diagnosis

Arif T, Fatima R, Sami M
Australas J Dermatol 2022 Nov;63(4):452-462. Epub 2022 Aug 11 doi: 10.1111/ajd.13890. PMID: 35950883
Kraus CN
JAMA Dermatol 2022 Sep 1;158(9):1088. doi: 10.1001/jamadermatol.2022.0359. PMID: 35793083
Rodríguez-Salgado P, García-Romero MT
Gac Med Mex 2019;155(5):522-531. doi: 10.24875/GMM.18004288. PMID: 31695234
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Therapy

Mortensen OE, Christensen SE, Løkkegaard E
Acta Obstet Gynecol Scand 2022 Jun;101(6):657-692. Epub 2022 Apr 28 doi: 10.1111/aogs.14353. PMID: 35484706Free PMC Article
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Bielsa Marsol I
Actas Dermosifiliogr 2013 Oct;104(8):654-66. Epub 2013 Aug 13 doi: 10.1016/j.adengl.2012.10.012. PMID: 23948159
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article

Prognosis

Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Tziotzios C, Lee JYW, Brier T, Saito R, Hsu CK, Bhargava K, Stefanato CM, Fenton DA, McGrath JA
J Am Acad Dermatol 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010. PMID: 30318136
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Fistarol SK, Itin PH
Curr Probl Dermatol 2011;40:58-70. Epub 2011 Feb 10 doi: 10.1159/000321051. PMID: 21325840
Murphy R
Dermatol Clin 2010 Oct;28(4):707-15. doi: 10.1016/j.det.2010.07.006. PMID: 20883914

Clinical prediction guides

Boero V, Cavalli R, Caia C, Berrettini A, Cetera GE, Monti E, Barbara G, Albertini GC, Restelli E, Libutti G, Motta T, Lazzari C, Vercellini P
Pediatr Dermatol 2023 May-Jun;40(3):472-475. Epub 2023 Mar 30 doi: 10.1111/pde.15308. PMID: 36998082
Arif T, Fatima R, Sami M
Australas J Dermatol 2022 Nov;63(4):452-462. Epub 2022 Aug 11 doi: 10.1111/ajd.13890. PMID: 35950883
Conteduca V, Medri M, Mazzoni L, De Giorgi U, Stanganelli I
Cancer Immunol Immunother 2022 Jun;71(6):1545-1548. Epub 2021 Oct 27 doi: 10.1007/s00262-021-03094-0. PMID: 34705086Free PMC Article
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Grassi S, Tadiotto Cicogna G, Magri F, Caterina Fortuna M, Caro G, Pernazza A, Soda G, Miraglia E, Giustini S, Carlesimo M, Rossi A
J Cosmet Dermatol 2021 Feb;20(2):615-620. Epub 2020 Aug 9 doi: 10.1111/jocd.13573. PMID: 32590887

Recent systematic reviews

Sanchez I, Ibraheim MK, Lee BA, Kraus CN, Elsensohn A
Am J Dermatopathol 2023 Dec 1;45(12):820-821. doi: 10.1097/DAD.0000000000002550. PMID: 37883982
Alharbi A, Khobrani A, Noor A, Alghamdi W, Alotaibi A, Alnuhait M, Haseeb A
Int J Environ Res Public Health 2022 Dec 29;20(1) doi: 10.3390/ijerph20010580. PMID: 36612904Free PMC Article
Pope R, Lee MH, Myers A, Song J, Abou Ghayda R, Kim JY, Hong SH, Lee SB, Koyanagi A, Jacob L, Smith L, Shin JI
J Sex Med 2022 Nov;19(11):1616-1624. Epub 2022 Sep 15 doi: 10.1016/j.jsxm.2022.07.011. PMID: 36115787
Veronesi G, Virdi A, Leuzzi M, Gurioli C, Chessa MA, Guglielmo A, Neri I
Pediatr Dermatol 2021 Sep;38(5):1012-1019. Epub 2021 Sep 24 doi: 10.1111/pde.14771. PMID: 34561885
Fergus KB, Lee AW, Baradaran N, Cohen AJ, Stohr BA, Erickson BA, Mmonu NA, Breyer BN
Urology 2020 Jan;135:11-19. Epub 2019 Oct 9 doi: 10.1016/j.urology.2019.09.034. PMID: 31605681

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