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Southern tick-associated rash illness

MedGen UID:
753176
•Concept ID:
C2733483
•
Disease or Syndrome
Synonyms: Masters disease; STARI Southern tick-associated rash illness
SNOMED CT: Masters disease (444100007); STARI - Southern tick-associated rash illness (444100007); Southern tick-associated rash illness (444100007)

Definition

A putative Borrelia infection causing acute manifestations similar to Lyme disease, particularly erythema migrans, following the bite of the lone star tick, Amblyomma americanum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSouthern tick-associated rash illness

Professional guidelines

PubMed

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy.
Smith GN, Moore KM, Hatchette TF, Nicholson J, Bowie W, Langley JM
J Obstet Gynaecol Can 2020 May;42(5):644-653. doi: 10.1016/j.jogc.2020.01.001. PMID: 32414479

Recent clinical studies

Etiology

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy.
Smith GN, Moore KM, Hatchette TF, Nicholson J, Bowie W, Langley JM
J Obstet Gynaecol Can 2020 May;42(5):644-653. doi: 10.1016/j.jogc.2020.01.001. PMID: 32414479
Metabolic differentiation of early Lyme disease from southern tick-associated rash illness (STARI).
Molins CR, Ashton LV, Wormser GP, Andre BG, Hess AM, Delorey MJ, Pilgard MA, Johnson BJ, Webb K, Islam MN, Pegalajar-Jurado A, Molla I, Jewett MW, Belisle JT
Sci Transl Med 2017 Aug 16;9(403) doi: 10.1126/scitranslmed.aal2717. PMID: 28814545Free PMC Article
Arthropod-Borne Diseases: The Camper's Uninvited Guests.
Juckett G
Microbiol Spectr 2015 Aug;3(4) doi: 10.1128/microbiolspec.IOL5-0001-2014. PMID: 26350321
Lyme borreliosis in human patients in Florida and Georgia, USA.
Clark KL, Leydet B, Hartman S
Int J Med Sci 2013;10(7):915-31. Epub 2013 May 23 doi: 10.7150/ijms.6273. PMID: 23781138Free PMC Article
Prevention of vector transmitted diseases with clove oil insect repellent.
Shapiro R
J Pediatr Nurs 2012 Aug;27(4):346-9. Epub 2011 May 25 doi: 10.1016/j.pedn.2011.03.011. PMID: 22703681

Diagnosis

Early Lyme Disease (Erythema Migrans) and Its Mimics (Southern Tick-Associated Rash Illness and Tick-Associated Rash Illness).
Strle F, Wormser GP
Infect Dis Clin North Am 2022 Sep;36(3):523-539. doi: 10.1016/j.idc.2022.03.005. PMID: 36116832
Metabolic differentiation of early Lyme disease from southern tick-associated rash illness (STARI).
Molins CR, Ashton LV, Wormser GP, Andre BG, Hess AM, Delorey MJ, Pilgard MA, Johnson BJ, Webb K, Islam MN, Pegalajar-Jurado A, Molla I, Jewett MW, Belisle JT
Sci Transl Med 2017 Aug 16;9(403) doi: 10.1126/scitranslmed.aal2717. PMID: 28814545Free PMC Article
Diseases from North America: focus on tick-borne infections.
Nathavitharana RR, Mitty JA
Clin Med (Lond) 2015 Feb;15(1):74-7. doi: 10.7861/clinmedicine.14-6-74. PMID: 25650204Free PMC Article
Tick bites and skin rashes.
Elston DM
Curr Opin Infect Dis 2010 Apr;23(2):132-8. doi: 10.1097/QCO.0b013e328335b09b. PMID: 20071986
Lyme disease update.
Hoppa E, Bachur R
Curr Opin Pediatr 2007 Jun;19(3):275-80. doi: 10.1097/MOP.0b013e3280e1269a. PMID: 17505186

Therapy

Early Lyme Disease (Erythema Migrans) and Its Mimics (Southern Tick-Associated Rash Illness and Tick-Associated Rash Illness).
Strle F, Wormser GP
Infect Dis Clin North Am 2022 Sep;36(3):523-539. doi: 10.1016/j.idc.2022.03.005. PMID: 36116832
Diseases from North America: focus on tick-borne infections.
Nathavitharana RR, Mitty JA
Clin Med (Lond) 2015 Feb;15(1):74-7. doi: 10.7861/clinmedicine.14-6-74. PMID: 25650204Free PMC Article
Southern Tick-Associated Rash Illness (STARI) in the North: STARI following a tick bite in Long Island, New York.
Feder HM Jr, Hoss DM, Zemel L, Telford SR 3rd, Dias F, Wormser GP
Clin Infect Dis 2011 Nov;53(10):e142-6. Epub 2011 Sep 21 doi: 10.1093/cid/cir553. PMID: 21940418
Tick bites and skin rashes.
Elston DM
Curr Opin Infect Dis 2010 Apr;23(2):132-8. doi: 10.1097/QCO.0b013e328335b09b. PMID: 20071986
Southern tick-associated rash illness: erythema migrans is not always Lyme disease.
Blanton L, Keith B, Brzezinski W
South Med J 2008 Jul;101(7):759-60. doi: 10.1097/SMJ.0b013e31817a8b3f. PMID: 18580719

Prognosis

Early Lyme Disease (Erythema Migrans) and Its Mimics (Southern Tick-Associated Rash Illness and Tick-Associated Rash Illness).
Strle F, Wormser GP
Infect Dis Clin North Am 2022 Sep;36(3):523-539. doi: 10.1016/j.idc.2022.03.005. PMID: 36116832

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