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Ovarian Endometriotic Cyst

MedGen UID:
75712
•Concept ID:
C0269102
•
Neoplastic Process
Synonyms: Endometrioma; Endometriomas
SNOMED CT: Endometriotic cyst (103678008); Endometrioma (103678008)

Definition

A cystic form of endometriosis affecting the ovary. It may or may not be associated with endometriosis in other areas in the pelvis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Endometriotic Cyst

Professional guidelines

PubMed

Role of surgical treatment in endometriosis.
D'Alterio MN, Saponara S, D'Ancona G, Russo M, Laganà AS, Sorrentino F, Nappi L, Angioni S
Minerva Obstet Gynecol 2021 Jun;73(3):317-332. doi: 10.23736/S2724-606X.21.04737-7. PMID: 34008386
Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study.
Nasu K, Nishida M, Ueda T, Yuge A, Takai N, Narahara H
Am J Physiol Endocrinol Metab 2007 Jul;293(1):E16-23. Epub 2006 Aug 8 doi: 10.1152/ajpendo.00135.2006. PMID: 16896168
Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis.
Nasu K, Nishida M, Ueda T, Takai N, Bing S, Narahara H, Miyakawa I
Mol Hum Reprod 2005 Nov;11(11):817-23. Epub 2006 Jan 3 doi: 10.1093/molehr/gah249. PMID: 16390854

Recent clinical studies

Etiology

Clinical and Pathological Significance of Cellular Atypia in Endometriosis.
Maier IM, Maier AC, Crișan A, Puşcaşiu L
Medicina (Kaunas) 2021 May 7;57(5) doi: 10.3390/medicina57050453. PMID: 34066945Free PMC Article
Risk factors for endometriotic-cyst associated ovarian cancer: A case controlled study.
Udomsinkul P, Triratanachart S, Oranratanaphan S
Taiwan J Obstet Gynecol 2020 Mar;59(2):269-274. doi: 10.1016/j.tjog.2020.01.016. PMID: 32127149
Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
Zhu G, Kong J, Fu X, Liu F, Huang H, Hong L, Wang K
Syst Biol Reprod Med 2020 Feb;66(1):59-69. Epub 2019 Nov 12 doi: 10.1080/19396368.2019.1688425. PMID: 31714804
Longitudinal changes in magnetic resonance imaging of malignant and borderline tumors associated with ovarian endometriotic cyst comparing with endometriotic cysts without arising malignancy.
Nishio N, Kido A, Kataoka M, Kuwahara R, Nakao K, Kurata Y, Matsumura N, Mandai M, Togashi K
Eur J Radiol 2018 Aug;105:175-181. Epub 2018 Jun 13 doi: 10.1016/j.ejrad.2018.06.007. PMID: 30017276
Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms.
Maeda D, Shih IeM
Adv Anat Pathol 2013 Jan;20(1):45-52. doi: 10.1097/PAP.0b013e31827bc24d. PMID: 23232571Free PMC Article

Diagnosis

Clinical and Pathological Significance of Cellular Atypia in Endometriosis.
Maier IM, Maier AC, Crișan A, Puşcaşiu L
Medicina (Kaunas) 2021 May 7;57(5) doi: 10.3390/medicina57050453. PMID: 34066945Free PMC Article
Risk factors for endometriotic-cyst associated ovarian cancer: A case controlled study.
Udomsinkul P, Triratanachart S, Oranratanaphan S
Taiwan J Obstet Gynecol 2020 Mar;59(2):269-274. doi: 10.1016/j.tjog.2020.01.016. PMID: 32127149
Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms.
Maeda D, Shih IeM
Adv Anat Pathol 2013 Jan;20(1):45-52. doi: 10.1097/PAP.0b013e31827bc24d. PMID: 23232571Free PMC Article
Conservative management of decidualized ovarian endometriotic cyst during pregnancy mimicking malignancy: case report and a review of the literature.
Tohya T, Tajima T
Eur J Gynaecol Oncol 2011;32(3):347-9. PMID: 21797133
CA 125 in the management of endometriosis.
Koninckx PR, Muyldermans M, Meuleman C, Cornillie FJ
Eur J Obstet Gynecol Reprod Biol 1993 Apr;49(1-2):109-13. doi: 10.1016/0028-2243(93)90134-x. PMID: 8365504

Therapy

Risk factors for endometriotic-cyst associated ovarian cancer: A case controlled study.
Udomsinkul P, Triratanachart S, Oranratanaphan S
Taiwan J Obstet Gynecol 2020 Mar;59(2):269-274. doi: 10.1016/j.tjog.2020.01.016. PMID: 32127149
Usefulness of hemostatic sealants for minimizing ovarian damage during laparoscopic cystectomy for endometriosis.
Choi C, Kim WY, Lee DH, Lee SH
J Obstet Gynaecol Res 2018 Mar;44(3):532-539. Epub 2017 Dec 21 doi: 10.1111/jog.13542. PMID: 29271052
Short-term histopathological effects of dienogest therapy on ovarian endometriomas: in vivo, nonrandomized, controlled trial.
Mabrouk M, Paradisi R, Arena A, Del Forno S, Matteucci C, Zannoni L, Caprara G, Seracchioli R
Gynecol Endocrinol 2018 May;34(5):399-403. Epub 2017 Nov 21 doi: 10.1080/09513590.2017.1405932. PMID: 29160135
Immunohistochemical Analysis of the Effect of Dienogest on Ovarian Endometriotic Cysts.
Nguyen TT, Hachisuga T, Urabe R, Ueda T, Kurita T, Kagami S, Kawagoe T, Hisaoka M
J UOEH 2016;38(4):271-278. doi: 10.7888/juoeh.38.271. PMID: 27980309
Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis.
Nasu K, Nishida M, Ueda T, Takai N, Bing S, Narahara H, Miyakawa I
Mol Hum Reprod 2005 Nov;11(11):817-23. Epub 2006 Jan 3 doi: 10.1093/molehr/gah249. PMID: 16390854

Prognosis

Cancers associated with extraovarian endometriosis at less common/rare sites: A nationwide survey in Japan.
Mandai M, Osuga Y, Hirata T, Enomoto T, Nakai H, Honda R, Taniguchi F, Katabuchi H
J Obstet Gynaecol Res 2020 Jun;46(6):917-923. Epub 2020 Mar 25 doi: 10.1111/jog.14244. PMID: 32212420
Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
Zhu G, Kong J, Fu X, Liu F, Huang H, Hong L, Wang K
Syst Biol Reprod Med 2020 Feb;66(1):59-69. Epub 2019 Nov 12 doi: 10.1080/19396368.2019.1688425. PMID: 31714804
Leyomiomatosis peritonealis disseminata associated with ovarian endometriosis in a patient submitted to hysteroscopic myomectomy.
Mabrouk M, Arena A, Raimondo D, Parisotto M, Caprara G, Seracchioli R
Fertil Steril 2019 Jun;111(6):1259-1261. Epub 2019 Apr 25 doi: 10.1016/j.fertnstert.2019.03.023. PMID: 31030890
Evaluation of risk factors for the recurrence of ovarian endometriomas.
Selcuk S, Cam C, Koc N, Kucukbas M, Ozkaya E, Eser A, Karateke A
Eur J Obstet Gynecol Reprod Biol 2016 Aug;203:56-60. Epub 2016 May 20 doi: 10.1016/j.ejogrb.2016.05.008. PMID: 27240262
Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma.
Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM
Int J Gynecol Cancer 2012 Oct;22(8):1310-5. doi: 10.1097/IGC.0b013e31826b5dcc. PMID: 22976498Free PMC Article

Clinical prediction guides

Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.
Zhu G, Kong J, Fu X, Liu F, Huang H, Hong L, Wang K
Syst Biol Reprod Med 2020 Feb;66(1):59-69. Epub 2019 Nov 12 doi: 10.1080/19396368.2019.1688425. PMID: 31714804
Longitudinal changes in magnetic resonance imaging of malignant and borderline tumors associated with ovarian endometriotic cyst comparing with endometriotic cysts without arising malignancy.
Nishio N, Kido A, Kataoka M, Kuwahara R, Nakao K, Kurata Y, Matsumura N, Mandai M, Togashi K
Eur J Radiol 2018 Aug;105:175-181. Epub 2018 Jun 13 doi: 10.1016/j.ejrad.2018.06.007. PMID: 30017276
Evaluation of risk factors for the recurrence of ovarian endometriomas.
Selcuk S, Cam C, Koc N, Kucukbas M, Ozkaya E, Eser A, Karateke A
Eur J Obstet Gynecol Reprod Biol 2016 Aug;203:56-60. Epub 2016 May 20 doi: 10.1016/j.ejogrb.2016.05.008. PMID: 27240262
Conservative management of decidualized ovarian endometriotic cyst during pregnancy mimicking malignancy: case report and a review of the literature.
Tohya T, Tajima T
Eur J Gynaecol Oncol 2011;32(3):347-9. PMID: 21797133
CA 125 in the management of endometriosis.
Koninckx PR, Muyldermans M, Meuleman C, Cornillie FJ
Eur J Obstet Gynecol Reprod Biol 1993 Apr;49(1-2):109-13. doi: 10.1016/0028-2243(93)90134-x. PMID: 8365504

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