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Aplastic anemia due to drugs

MedGen UID:
75769
•Concept ID:
C0271909
•
Disease or Syndrome
Synonyms: Drug induced aplastic anemia; Drug-Induced Aplastic Anemia
SNOMED CT: Drug induced aplastic anemia (267527002); Aplastic anemia due to drugs (267527002)

Definition

A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAplastic anemia due to drugs

Professional guidelines

PubMed

An evaluation of avatrombopag for the treatment of thrombocytopenia.
Virk ZM, Kuter DJ, Al-Samkari H
Expert Opin Pharmacother 2021 Feb;22(3):273-280. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1841748. PMID: 33095074
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Aplastic anemia: biology and treatment.
Gale RP, Champlin RE, Feig SA, Fitchen JH
Ann Intern Med 1981 Oct;95(4):477-94. doi: 10.7326/0003-4819-95-4-477. PMID: 6116472

Recent clinical studies

Etiology

Inherited bone marrow failure in the pediatric patient.
Dokal I, Tummala H, Vulliamy T
Blood 2022 Aug 11;140(6):556-570. doi: 10.1182/blood.2020006481. PMID: 35605178Free PMC Article
Emerging patterns in clonal haematopoiesis.
Capo-Chichi JM, Michaels P, Tremblay-Le May R, Abelson S, Hasserjian RP, Xia D
J Clin Pathol 2019 Jul;72(7):453-459. Epub 2019 Jun 4 doi: 10.1136/jclinpath-2019-205851. PMID: 31164443
Acquired aplastic anemia.
Keohane EM
Clin Lab Sci 2004 Summer;17(3):165-71. PMID: 15314891
Myelodysplastic syndromes.
Greenberg PL, Young NS, Gattermann N
Hematology Am Soc Hematol Educ Program 2002:136-61. doi: 10.1182/asheducation-2002.1.136. PMID: 12446422
Felbamate.
Pellock JM
Epilepsia 1999;40 Suppl 5:S57-62. doi: 10.1111/j.1528-1157.1999.tb00920.x. PMID: 10530695

Diagnosis

Inherited bone marrow failure in the pediatric patient.
Dokal I, Tummala H, Vulliamy T
Blood 2022 Aug 11;140(6):556-570. doi: 10.1182/blood.2020006481. PMID: 35605178Free PMC Article
Diamond-Blackfan anemia.
Da Costa L, Leblanc T, Mohandas N
Blood 2020 Sep 10;136(11):1262-1273. doi: 10.1182/blood.2019000947. PMID: 32702755Free PMC Article
Chromosome instability syndromes.
Taylor AMR, Rothblum-Oviatt C, Ellis NA, Hickson ID, Meyer S, Crawford TO, Smogorzewska A, Pietrucha B, Weemaes C, Stewart GS
Nat Rev Dis Primers 2019 Sep 19;5(1):64. doi: 10.1038/s41572-019-0113-0. PMID: 31537806Free PMC Article
Approach to pancytopenia: Diagnostic algorithm for clinical hematologists.
Gnanaraj J, Parnes A, Francis CW, Go RS, Takemoto CM, Hashmi SK
Blood Rev 2018 Sep;32(5):361-367. Epub 2018 Mar 5 doi: 10.1016/j.blre.2018.03.001. PMID: 29555368
Congenital Hemolytic Anemia.
Haley K
Med Clin North Am 2017 Mar;101(2):361-374. Epub 2016 Dec 8 doi: 10.1016/j.mcna.2016.09.008. PMID: 28189176

Therapy

Hetrombopag: First Approval.
Syed YY
Drugs 2021 Sep;81(13):1581-1585. doi: 10.1007/s40265-021-01575-1. PMID: 34357499
Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists.
Gilreath J, Lo M, Bubalo J
Drugs 2021 Jul;81(11):1285-1305. Epub 2021 Jun 23 doi: 10.1007/s40265-021-01553-7. PMID: 34160821Free PMC Article
Diamond-Blackfan anemia.
Da Costa L, Leblanc T, Mohandas N
Blood 2020 Sep 10;136(11):1262-1273. doi: 10.1182/blood.2019000947. PMID: 32702755Free PMC Article
Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298
Felbamate.
Pellock JM
Epilepsia 1999;40 Suppl 5:S57-62. doi: 10.1111/j.1528-1157.1999.tb00920.x. PMID: 10530695

Prognosis

Aplastic anaemia.
Brodsky RA, Jones RJ
Lancet 2005 May 7-13;365(9471):1647-56. doi: 10.1016/S0140-6736(05)66515-4. PMID: 15885298
Acquired aplastic anemia.
Keohane EM
Clin Lab Sci 2004 Summer;17(3):165-71. PMID: 15314891
Myelodysplastic syndromes.
Greenberg PL, Young NS, Gattermann N
Hematology Am Soc Hematol Educ Program 2002:136-61. doi: 10.1182/asheducation-2002.1.136. PMID: 12446422
Aplastic anemia.
Storb R
J Intraven Nurs 1997 Nov-Dec;20(6):317-22. PMID: 9423394
Drug-induced anaemias.
Girdwood RH
Drugs 1976;11(5):394-404. doi: 10.2165/00003495-197611050-00003. PMID: 782836

Clinical prediction guides

New-onset aplastic anemia after SARS-CoV-2 vaccination.
Chatzikalil E, Kattamis A, Diamantopoulos P, Solomou EE
Int J Hematol 2023 Dec;118(6):667-681. Epub 2023 Sep 28 doi: 10.1007/s12185-023-03666-z. PMID: 37768509
Eltrombopag in Immune Thrombocytopenia, Aplastic Anemia, and Myelodysplastic Syndrome: From Megakaryopoiesis to Immunomodulation.
Fattizzo B, Levati G, Cassin R, Barcellini W
Drugs 2019 Aug;79(12):1305-1319. doi: 10.1007/s40265-019-01159-0. PMID: 31292909
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Aplastic anemia: what have we learned from animal models and from the clinic.
Scheinberg P, Chen J
Semin Hematol 2013 Apr;50(2):156-64. Epub 2013 Jun 11 doi: 10.1053/j.seminhematol.2013.03.028. PMID: 24216172
Pharmacogenetics and blood dyscrasias.
Spielberg SP
Eur J Haematol Suppl 1996;60:93-7. doi: 10.1111/j.1600-0609.1996.tb01653.x. PMID: 8987249

Recent systematic reviews

Clinical characteristics of antithyroid drug-induced aplastic anemia cases over the past 30 years.
Cheng Y, Xia XY, Zhang W, Ren L, Tian CF, Liu D, Xue G
Front Endocrinol (Lausanne) 2023;14:1064723. Epub 2023 Jan 27 doi: 10.3389/fendo.2023.1064723. PMID: 36777352Free PMC Article
Temozolomide-related idiosyncratic and other uncommon toxicities: a systematic review.
Dixit S, Baker L, Walmsley V, Hingorani M
Anticancer Drugs 2012 Nov;23(10):1099-106. doi: 10.1097/CAD.0b013e328356f5b0. PMID: 22850321
ATG plus cyclosporine reduces all-cause mortality in patients with severe aplastic anemia--systematic review and meta-analysis.
Gafter-Gvili A, Ram R, Gurion R, Paul M, Yeshurun M, Raanani P, Shpilberg O
Acta Haematol 2008;120(4):237-43. Epub 2009 Feb 25 doi: 10.1159/000203403. PMID: 19246887
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Singh PC, Ballas SK
Cochrane Database Syst Rev 2007 Oct 17;(4):CD003426. doi: 10.1002/14651858.CD003426.pub2. PMID: 17943791
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
Riddington C, De Franceschi L
Cochrane Database Syst Rev 2002;(4):CD003426. doi: 10.1002/14651858.CD003426. PMID: 12519597

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