U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult Burkitt Leukemia

MedGen UID:
75998
•Concept ID:
C0279591
•
Neoplastic Process
Synonym: Adult Burkitt's Leukemia

Definition

The leukemic counterpart of Burkitt lymphoma occurring in adults. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Burkitt Leukemia

Professional guidelines

PubMed

Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults.
Goldman S, Cairo MS
Best Pract Res Clin Haematol 2023 Jun;36(2):101463. Epub 2023 Apr 2 doi: 10.1016/j.beha.2023.101463. PMID: 37353299
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

Inotuzumab ozogamicin in B-cell precursor acute lymphoblastic leukemia: efficacy, toxicity, and practical considerations.
Rubinstein JD, O'Brien MM
Front Immunol 2023;14:1237738. Epub 2023 Aug 3 doi: 10.3389/fimmu.2023.1237738. PMID: 37600823Free PMC Article
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947
Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia.
Thomas DA, Faderl S, O'Brien S, Bueso-Ramos C, Cortes J, Garcia-Manero G, Giles FJ, Verstovsek S, Wierda WG, Pierce SA, Shan J, Brandt M, Hagemeister FB, Keating MJ, Cabanillas F, Kantarjian H
Cancer 2006 Apr 1;106(7):1569-80. doi: 10.1002/cncr.21776. PMID: 16502413
Modified magrath regimens for adults with Burkitt and Burkitt-like lymphomas: preserved efficacy with decreased toxicity.
Lacasce A, Howard O, Lib S, Fisher D, Weng A, Neuberg D, Shipp M
Leuk Lymphoma 2004 Apr;45(4):761-7. doi: 10.1080/1042819031000141301. PMID: 15160953

Diagnosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Burkitt lymphoma.
López C, Burkhardt B, Chan JKC, Leoncini L, Mbulaiteye SM, Ogwang MD, Orem J, Rochford R, Roschewski M, Siebert R
Nat Rev Dis Primers 2022 Dec 15;8(1):78. doi: 10.1038/s41572-022-00404-3. PMID: 36522349
Genes associated with diagnosis and prognosis of Burkitt lymphoma.
Doughan A, Salifu SP
IET Syst Biol 2022 Dec;16(6):220-229. Epub 2022 Nov 10 doi: 10.1049/syb2.12054. PMID: 36354023Free PMC Article
Adult Burkitt's lymphoma.
Bociek RG
Clin Lymphoma 2005 Jun;6(1):11-20. doi: 10.3816/clm.2005.n.021. PMID: 15989701
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787

Therapy

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947
Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia.
Thomas DA, Faderl S, O'Brien S, Bueso-Ramos C, Cortes J, Garcia-Manero G, Giles FJ, Verstovsek S, Wierda WG, Pierce SA, Shan J, Brandt M, Hagemeister FB, Keating MJ, Cabanillas F, Kantarjian H
Cancer 2006 Apr 1;106(7):1569-80. doi: 10.1002/cncr.21776. PMID: 16502413
Modified magrath regimens for adults with Burkitt and Burkitt-like lymphomas: preserved efficacy with decreased toxicity.
Lacasce A, Howard O, Lib S, Fisher D, Weng A, Neuberg D, Shipp M
Leuk Lymphoma 2004 Apr;45(4):761-7. doi: 10.1080/1042819031000141301. PMID: 15160953

Prognosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma.
Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM
Blood 2019 Mar 21;133(12):1313-1324. Epub 2019 Jan 7 doi: 10.1182/blood-2018-09-871418. PMID: 30617194Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947

Clinical prediction guides

Prediction of severe CRS and determination of biomarkers in B cell-acute lymphoblastic leukemia treated with CAR-T cells.
Wei Z, Xu J, Zhao C, Zhang M, Xu N, Kang L, Lou X, Yu L, Feng W
Front Immunol 2023;14:1273507. Epub 2023 Oct 3 doi: 10.3389/fimmu.2023.1273507. PMID: 37854590Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Low-intensity therapy in adults with Burkitt's lymphoma.
Dunleavy K, Pittaluga S, Shovlin M, Steinberg SM, Cole D, Grant C, Widemann B, Staudt LM, Jaffe ES, Little RF, Wilson WH
N Engl J Med 2013 Nov 14;369(20):1915-25. doi: 10.1056/NEJMoa1308392. PMID: 24224624Free PMC Article
Burkitt's and Burkitt-like lymphoma.
Evens AM, Gordon LI
Curr Treat Options Oncol 2002 Aug;3(4):291-305. doi: 10.1007/s11864-002-0029-9. PMID: 12074766

Recent systematic reviews

EFFICACY OF AUTOLOGOUS STEM CELL TRANSPLANTATION IN ADULT BURKITT/BURKITT-LIKE LYMPHOMA: A SYSTEMATIC REVIEW.
Joshi U, Subedi R, Nepal G, Gyawali S, Agrawal V, Poudyal BS, Bhatt VR, D'Angelo CR
Exp Oncol 2022 Nov;44(3):190-197. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-3.18599. PMID: 36325697
Chemotherapy Treatments for Burkitt Lymphoma: Systematic Review of Interventional Studies.
Della Rocca AM, Leonart LP, Ferreira VL, Tonin FS, Steffenello-Durigon G, Del Moral JAG, Fernandez-Llimos F, Pontarolo R
Clin Lymphoma Myeloma Leuk 2021 Aug;21(8):514-525. Epub 2021 Apr 3 doi: 10.1016/j.clml.2021.03.012. PMID: 33947633
Burkitt and Burkitt-Like Lymphomas: a Systematic Review.
Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513
Effect of rituximab on adult Burkitt's lymphoma: a systematic review and meta-analysis.
Nie M, Wang Y, Bi XW, Xia Y, Sun P, Liu PP, Li ZM, Jiang WQ
Ann Hematol 2016 Jan;95(1):19-26. Epub 2015 Oct 1 doi: 10.1007/s00277-015-2501-1. PMID: 26423805
Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.
Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...