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Pancreatic Beta Cell Adenoma

MedGen UID:
76020
•Concept ID:
C0279719
•
Neoplastic Process

Definition

An adenoma arising from the beta cells of the pancreas. It produces insulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Beta Cell Adenoma

Professional guidelines

PubMed

Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium.
Kiran RP, Kochhar GS, Kariv R, Rex DK, Sugita A, Rubin DT, Navaneethan U, Hull TL, Ko HM, Liu X, Kachnic LA, Strong S, Iacucci M, Bemelman W, Fleshner P, Safyan RA, Kotze PG, D'Hoore A, Faiz O, Lo S, Ashburn JH, Spinelli A, Bernstein CN, Kane SV, Cross RK, Schairer J, McCormick JT, Farraye FA, Chang S, Scherl EJ, Schwartz DA, Bruining DH, Philpott J, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sandborn WJ, Silverberg MS, Pardi DS, Church JM, Shen B
Lancet Gastroenterol Hepatol 2022 Sep;7(9):871-893. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00039-5. PMID: 35798022
Management of Hepatocellular Adenoma: Recent Advances.
Agrawal S, Agarwal S, Arnason T, Saini S, Belghiti J
Clin Gastroenterol Hepatol 2015 Jul;13(7):1221-30. Epub 2014 Jun 5 doi: 10.1016/j.cgh.2014.05.023. PMID: 24909909
Incretins: their physiology and application in the treatment of diabetes mellitus.
Tasyurek HM, Altunbas HA, Balci MK, Sanlioglu S
Diabetes Metab Res Rev 2014 Jul;30(5):354-71. doi: 10.1002/dmrr.2501. PMID: 24989141

Recent clinical studies

Etiology

Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.
Del Sindaco P, Casucci G, Pampanelli S, Polonsky K, Fanelli C, Torlone E, Santeusanio F, Brunetti P, Bolli GB
Eur J Endocrinol 1997 Jan;136(1):96-9. doi: 10.1530/eje.0.1360096. PMID: 9037134

Diagnosis

Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400
Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.
Del Sindaco P, Casucci G, Pampanelli S, Polonsky K, Fanelli C, Torlone E, Santeusanio F, Brunetti P, Bolli GB
Eur J Endocrinol 1997 Jan;136(1):96-9. doi: 10.1530/eje.0.1360096. PMID: 9037134
Separate pancreatic gastrin cell and beta-cell adenomas: report of a patient with multiple endocrine adenomatosis type 1.
Peurifoy JT, Gomez LG, Thompson JC
Arch Surg 1979 Aug;114(8):956-8. doi: 10.1001/archsurg.1979.01370320088018. PMID: 37817
Nonautonomous function of a pancreatic insulinoma.
Rayfield EJ, Pulini M, Golub A, Rubenstein AH, Horwitz DL
J Clin Endocrinol Metab 1976 Dec;43(6):1307-11. doi: 10.1210/jcem-43-6-1307. PMID: 187613

Therapy

Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400

Prognosis

Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.
Del Sindaco P, Casucci G, Pampanelli S, Polonsky K, Fanelli C, Torlone E, Santeusanio F, Brunetti P, Bolli GB
Eur J Endocrinol 1997 Jan;136(1):96-9. doi: 10.1530/eje.0.1360096. PMID: 9037134

Clinical prediction guides

Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.
Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400
Crystalline structures in human pancreatic beta cell adenoma.
Mori H, Kawai T, Tanaka T, Fujii M, Takahashi M, Miyashita T
Acta Pathol Jpn 1978 May;28(3):471-9. doi: 10.1111/j.1440-1827.1978.tb01271.x. PMID: 210622

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