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Leukemoid reaction of the newborn

MedGen UID:
760708
•Concept ID:
C3536761
•
Finding
Synonyms: Infantile pseudoleukemia; Transient Leukemoid Reaction of the Newborn
SNOMED CT: Leukemoid reaction of the newborn (191273000); Infantile pseudoleukemia (191273000)

Definition

Increased white blood cell count and increased neutrophil precursors resembling leukemia in a neonate or fetus. Often, this is a response to medications received, infection or Down syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemoid reaction of the newborn

Professional guidelines

PubMed

Rapid next-generation sequencing aids in diagnosis of transient abnormal myelopoiesis in a phenotypically normal newborn.
Aziz-Bose R, Wachter F, Chiarle R, Lindeman NI, Kim AS, Degar BA, Davies K, Pikman Y
Blood Adv 2022 May 10;6(9):2893-2896. doi: 10.1182/bloodadvances.2021006865. PMID: 35090166Free PMC Article

Recent clinical studies

Etiology

Leukemogenesis in infants and young children with trisomy 21.
Roberts I
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):1-8. doi: 10.1182/hematology.2022000395. PMID: 36485097Free PMC Article
Hematological disorders in children with Down syndrome.
Triarico S, Trombatore G, Capozza MA, Romano A, Mastrangelo S, Attinà G, Maurizi P, Ruggiero A
Expert Rev Hematol 2022 Feb;15(2):127-135. Epub 2022 Feb 28 doi: 10.1080/17474086.2022.2044780. PMID: 35184659
Neonatal Leukemia.
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502
Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Leukemoid reaction in the pediatric population: etiologies, outcome, and implications.
Hoofien A, Yarden-Bilavski H, Ashkenazi S, Chodick G, Livni G
Eur J Pediatr 2018 Jul;177(7):1029-1036. Epub 2018 Apr 25 doi: 10.1007/s00431-018-3155-5. PMID: 29696475

Diagnosis

Hematological disorders in children with Down syndrome.
Triarico S, Trombatore G, Capozza MA, Romano A, Mastrangelo S, Attinà G, Maurizi P, Ruggiero A
Expert Rev Hematol 2022 Feb;15(2):127-135. Epub 2022 Feb 28 doi: 10.1080/17474086.2022.2044780. PMID: 35184659
Trisomy 21, transposition of the great arteries and abnormal myelopoiesis.
Mishra C, Kadiyani L, Ramakrishnan S, Sehgal T
Cardiol Young 2022 Jan;32(1):142-143. Epub 2021 Jun 21 doi: 10.1017/S1047951121002444. PMID: 35034684
Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Placental Pathology in Down Syndrome-Associated Transient Abnormal Myelopoiesis.
Kuo E, Kumarapeli AR
Arch Pathol Lab Med 2020 Mar;144(3):388-393. Epub 2019 Apr 10 doi: 10.5858/arpa.2018-0248-RS. PMID: 30969155
Leukemoid reaction in the pediatric population: etiologies, outcome, and implications.
Hoofien A, Yarden-Bilavski H, Ashkenazi S, Chodick G, Livni G
Eur J Pediatr 2018 Jul;177(7):1029-1036. Epub 2018 Apr 25 doi: 10.1007/s00431-018-3155-5. PMID: 29696475

Therapy

Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study.
Flasinski M, Scheibke K, Zimmermann M, Creutzig U, Reinhardt K, Verwer F, de Haas V, van der Velden VHJ, von Neuhoff C, Zwaan CM, Reinhardt D, Klusmann JH
Blood Adv 2018 Jul 10;2(13):1532-1540. doi: 10.1182/bloodadvances.2018018945. PMID: 29959152Free PMC Article
Extreme hyperleucocytosis of the premature.
Jansen E, Emmen J, Mohns T, Donker A
BMJ Case Rep 2013 Apr 19;2013 doi: 10.1136/bcr-2012-008385. PMID: 23606381Free PMC Article
Leukemoid reaction in extremely low-birth-weight infants.
Rastogi S, Rastogi D, Sundaram R, Kulpa J, Parekh AJ
Am J Perinatol 1999;16(2):93-7. doi: 10.1055/s-2007-993843. PMID: 10355917
Total leukocyte and neutrophil count changes associated with antenatal betamethasone administration in premature infants.
Barak M, Cohen A, Herschkowitz S
Acta Paediatr 1992 Oct;81(10):760-3. doi: 10.1111/j.1651-2227.1992.tb12098.x. PMID: 1421878
Effect of antenatal dexamethasone on neonatal leukocyte count.
Zachman RD, Bauer CR, Boehm J, Korones SB, Rigatto H, Rao AV
J Perinatol 1988 Spring;8(2):111-3. PMID: 3057139

Prognosis

"TAM"ing of the shrew-challenges in the diagnosis of Neonatal leukemia with Down's syndrome -A case report with literature review.
Manohar S, Jayakumar N
Indian J Pathol Microbiol 2022 Jul-Sep;65(3):699-701. doi: 10.4103/ijpm.ijpm_731_21. PMID: 35900507
Hematological disorders in children with Down syndrome.
Triarico S, Trombatore G, Capozza MA, Romano A, Mastrangelo S, Attinà G, Maurizi P, Ruggiero A
Expert Rev Hematol 2022 Feb;15(2):127-135. Epub 2022 Feb 28 doi: 10.1080/17474086.2022.2044780. PMID: 35184659
Factors influencing platelet normalization of transient abnormal myelopoiesis.
Nakamura W, Goto H, Hayashi A, Keino D, Sugiyama M, Miyagawa N, Iwasaki F, Hamanoue S, Yokosuka T, Goto S, Toyoshima K
Pediatr Int 2020 Aug;62(8):907-910. Epub 2020 Jul 9 doi: 10.1111/ped.14214. PMID: 32124502
Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome.
Watanabe K
Pediatr Int 2019 Mar;61(3):222-229. Epub 2019 Mar 4 doi: 10.1111/ped.13776. PMID: 30593694
Prenatal therapy in transient abnormal myelopoiesis: a systematic review.
Tamblyn JA, Norton A, Spurgeon L, Donovan V, Bedford Russell A, Bonnici J, Perkins K, Vyas P, Roberts I, Kilby MD
Arch Dis Child Fetal Neonatal Ed 2016 Jan;101(1):F67-71. Epub 2015 May 8 doi: 10.1136/archdischild-2014-308004. PMID: 25956670

Clinical prediction guides

Myeloid cell thrombus and fetal vascular malperfusion in placentas with transient abnormal myelopoiesis.
Tomimori K, Kodama Y, Tanaka H, Yamashita A, Gi T, Asada Y, Doi K, Katsuragi S, Sato Y
Virchows Arch 2022 Jun;480(6):1181-1187. Epub 2022 Feb 24 doi: 10.1007/s00428-022-03289-5. PMID: 35199205
Factors influencing platelet normalization of transient abnormal myelopoiesis.
Nakamura W, Goto H, Hayashi A, Keino D, Sugiyama M, Miyagawa N, Iwasaki F, Hamanoue S, Yokosuka T, Goto S, Toyoshima K
Pediatr Int 2020 Aug;62(8):907-910. Epub 2020 Jul 9 doi: 10.1111/ped.14214. PMID: 32124502
Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome.
Watanabe K
Pediatr Int 2019 Mar;61(3):222-229. Epub 2019 Mar 4 doi: 10.1111/ped.13776. PMID: 30593694
Leukemoid reaction in the pediatric population: etiologies, outcome, and implications.
Hoofien A, Yarden-Bilavski H, Ashkenazi S, Chodick G, Livni G
Eur J Pediatr 2018 Jul;177(7):1029-1036. Epub 2018 Apr 25 doi: 10.1007/s00431-018-3155-5. PMID: 29696475
Prenatal therapy in transient abnormal myelopoiesis: a systematic review.
Tamblyn JA, Norton A, Spurgeon L, Donovan V, Bedford Russell A, Bonnici J, Perkins K, Vyas P, Roberts I, Kilby MD
Arch Dis Child Fetal Neonatal Ed 2016 Jan;101(1):F67-71. Epub 2015 May 8 doi: 10.1136/archdischild-2014-308004. PMID: 25956670

Recent systematic reviews

Prenatal therapy in transient abnormal myelopoiesis: a systematic review.
Tamblyn JA, Norton A, Spurgeon L, Donovan V, Bedford Russell A, Bonnici J, Perkins K, Vyas P, Roberts I, Kilby MD
Arch Dis Child Fetal Neonatal Ed 2016 Jan;101(1):F67-71. Epub 2015 May 8 doi: 10.1136/archdischild-2014-308004. PMID: 25956670

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