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Common terminology criteria for adverse events grade 4

MedGen UID:
760809
Concept ID:
C3537125
Finding
Synonyms: CTCAE grade 4; Grade 4 Life Threatening or Disabling Adverse Event; Life Threatening Adverse Event; Life Threatening or Disabling Adverse Event; Standard Toxicity Grade 4
SNOMED CT: Common terminology criteria for adverse events grade 4 (446441000124102); CTCAE grade 4 (446441000124102)

Definition

Life-threatening consequences; urgent intervention indicated. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCommon terminology criteria for adverse events grade 4

Professional guidelines

PubMed

Winkler CS, Sandhu J, Pettke E, Merchea A, Fong Y, Kumara HMCS, Whelan RL
Dis Colon Rectum 2020 Feb;63(2):242-255. doi: 10.1097/DCR.0000000000001565. PMID: 31914116

Recent clinical studies

Etiology

Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
Young L, Finnigan S, Streicher H, Chen HX, Murray J, Sen HN, Sharon E
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2020-002119. PMID: 34226280Free PMC Article
Williams AM, Cheung YT, Hyun G, Liu W, Ness KK, Ehrhardt MJ, Mulrooney DA, Bhakta N, Banerjee P, Brinkman TM, Green DM, Chemaitilly W, Huang IC, Srivastava D, Hudson MM, Robison LL, Krull KR
Ann Neurol 2021 Mar;89(3):534-545. Epub 2020 Dec 31 doi: 10.1002/ana.25981. PMID: 33274777Free PMC Article
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article

Diagnosis

Conte P, Ascierto PA, Patelli G, Danesi R, Vanzulli A, Sandomenico F, Tarsia P, Cattelan A, Comes A, De Laurentiis M, Falcone A, Regge D, Richeldi L, Siena S
ESMO Open 2022 Apr;7(2):100404. Epub 2022 Feb 24 doi: 10.1016/j.esmoop.2022.100404. PMID: 35219244Free PMC Article
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Folch EE, Pritchett MA, Nead MA, Bowling MR, Murgu SD, Krimsky WS, Murillo BA, LeMense GP, Minnich DJ, Bansal S, Ellis BQ, Mahajan AK, Gildea TR, Bechara RI, Sztejman E, Flandes J, Rickman OB, Benzaquen S, Hogarth DK, Linden PA, Wahidi MM, Mattingley JS, Hood KL, Lin H, Wolvers JJ, Khandhar SJ; NAVIGATE Study Investigators
J Thorac Oncol 2019 Mar;14(3):445-458. Epub 2018 Nov 23 doi: 10.1016/j.jtho.2018.11.013. PMID: 30476574
Parker CC, James ND, Brawley CD, Clarke NW, Hoyle AP, Ali A, Ritchie AWS, Attard G, Chowdhury S, Cross W, Dearnaley DP, Gillessen S, Gilson C, Jones RJ, Langley RE, Malik ZI, Mason MD, Matheson D, Millman R, Russell JM, Thalmann GN, Amos CL, Alonzi R, Bahl A, Birtle A, Din O, Douis H, Eswar C, Gale J, Gannon MR, Jonnada S, Khaksar S, Lester JF, O'Sullivan JM, Parikh OA, Pedley ID, Pudney DM, Sheehan DJ, Srihari NN, Tran ATH, Parmar MKB, Sydes MR; Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
Lancet 2018 Dec 1;392(10162):2353-2366. Epub 2018 Oct 21 doi: 10.1016/S0140-6736(18)32486-3. PMID: 30355464Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Therapy

Gazzah A, Bedard PL, Hierro C, Kang YK, Abdul Razak A, Ryu MH, Demers B, Fagniez N, Henry C, Hospitel M, Soria JC, Tabernero J
Ann Oncol 2022 Apr;33(4):416-425. Epub 2022 Jan 10 doi: 10.1016/j.annonc.2021.12.012. PMID: 35026412
Li D, Sun CL, Kim H, Soto-Perez-de-Celis E, Chung V, Koczywas M, Fakih M, Chao J, Cabrera Chien L, Charles K, Hughes SFDS, Katheria V, Trent M, Roberts E, Jayani R, Moreno J, Kelly C, Sedrak MS, Dale W
JAMA Oncol 2021 Nov 1;7(11):e214158. Epub 2021 Nov 18 doi: 10.1001/jamaoncol.2021.4158. PMID: 34591080Free PMC Article
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Rogers CL, Won M, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Fogh SE, Youssef E, Deb N, Kwok Y, Robinson CG, Shu HK, Fisher BJ, Panet-Raymond V, McMillan WG, de Groot JF, Zhang P, Mehta MP
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):790-799. Epub 2019 Nov 29 doi: 10.1016/j.ijrobp.2019.11.028. PMID: 31786276Free PMC Article

Prognosis

Kanji S, Morin S, Agtarap K, Purkayastha D, Thabet P, Bosse D, Wang X, Lunny C, Hutton B
Drugs 2022 May;82(7):793-809. Epub 2022 Apr 13 doi: 10.1007/s40265-022-01707-1. PMID: 35416592
Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543Free PMC Article
Folch EE, Pritchett MA, Nead MA, Bowling MR, Murgu SD, Krimsky WS, Murillo BA, LeMense GP, Minnich DJ, Bansal S, Ellis BQ, Mahajan AK, Gildea TR, Bechara RI, Sztejman E, Flandes J, Rickman OB, Benzaquen S, Hogarth DK, Linden PA, Wahidi MM, Mattingley JS, Hood KL, Lin H, Wolvers JJ, Khandhar SJ; NAVIGATE Study Investigators
J Thorac Oncol 2019 Mar;14(3):445-458. Epub 2018 Nov 23 doi: 10.1016/j.jtho.2018.11.013. PMID: 30476574
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Clinical prediction guides

Misawa S, Denda T, Kodama S, Suzuki T, Naito Y, Kogawa T, Takada M, Suichi T, Shiosakai K, Kuwabara S; MiroCIP study group
BMC Cancer 2023 Nov 11;23(1):1098. doi: 10.1186/s12885-023-11560-4. PMID: 37951905Free PMC Article
Li D, Sun CL, Kim H, Soto-Perez-de-Celis E, Chung V, Koczywas M, Fakih M, Chao J, Cabrera Chien L, Charles K, Hughes SFDS, Katheria V, Trent M, Roberts E, Jayani R, Moreno J, Kelly C, Sedrak MS, Dale W
JAMA Oncol 2021 Nov 1;7(11):e214158. Epub 2021 Nov 18 doi: 10.1001/jamaoncol.2021.4158. PMID: 34591080Free PMC Article
Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC
Clin Trials 2021 Feb;18(1):104-114. Epub 2020 Dec 1 doi: 10.1177/1740774520975120. PMID: 33258687Free PMC Article
Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, Lu Q, Gao H, Jiang H, Wang H, Yuan D, Ma H, Wang H, Li Z, Zhai B
Clin Cancer Res 2020 Aug 1;26(15):3979-3989. Epub 2020 May 5 doi: 10.1158/1078-0432.CCR-19-3259. PMID: 32371538
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M, Cecchi F, Arecco L, Fraguglia M, Pronzato P, Genova C, Del Mastro L, Lambertini M, Spagnolo F
Eur J Cancer 2023 Jul;188:64-79. Epub 2023 Apr 24 doi: 10.1016/j.ejca.2023.04.010. PMID: 37196485
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article
Abdel-Aleem H, Shaaban OM, Abdel-Aleem MA, Aboelfadle Mohamed A
Cochrane Database Syst Rev 2022 Dec 1;12(12):CD014508. doi: 10.1002/14651858.CD014508. PMID: 36453699Free PMC Article
Han MA, Maisch P, Jung JH, Hwang JE, Narayan V, Cleves A, Hwang EC, Dahm P
Cochrane Database Syst Rev 2021 Jun 14;6(6):CD009294. doi: 10.1002/14651858.CD009294.pub3. PMID: 34125951Free PMC Article
Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR
JAMA Oncol 2021 Jul 1;7(7):1033-1040. doi: 10.1001/jamaoncol.2021.1262. PMID: 33983393Free PMC Article

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