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Alzheimer disease 17(AD17)

MedGen UID:
767366
Concept ID:
C3554452
Disease or Syndrome
Synonyms: AD17; ALZHEIMER DISEASE 17, LATE-ONSET
 
Monarch Initiative: MONDO:0014036
OMIM®: 615080

Definition

A form of Alzheimer''s disease associated with mutation(s) in the TREM2 gene, encoding triggering receptor expressed on myeloid cells 2. [from NCI]

Professional guidelines

PubMed

Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Kumar S, Mittal A, Babu D, Mittal A
Curr Diabetes Rev 2021;17(4):437-456. doi: 10.2174/1573399816666201103143225. PMID: 33143632
McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P; prodromal DLB Diagnostic Study Group
Neurology 2020 Apr 28;94(17):743-755. Epub 2020 Apr 2 doi: 10.1212/WNL.0000000000009323. PMID: 32241955Free PMC Article

Recent clinical studies

Etiology

Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC
Mol Neurodegener 2022 Nov 8;17(1):72. doi: 10.1186/s13024-022-00574-4. PMID: 36348357Free PMC Article
Koutsodendris N, Nelson MR, Rao A, Huang Y
Annu Rev Pathol 2022 Jan 24;17:73-99. Epub 2021 Aug 30 doi: 10.1146/annurev-pathmechdis-030421-112756. PMID: 34460318
Lanfranco MF, Ng CA, Rebeck GW
Int J Mol Sci 2020 Sep 1;21(17) doi: 10.3390/ijms21176336. PMID: 32882843Free PMC Article
Lloret A, Esteve D, Lloret MA, Cervera-Ferri A, Lopez B, Nepomuceno M, Monllor P
Int J Mol Sci 2019 Nov 6;20(22) doi: 10.3390/ijms20225536. PMID: 31698826Free PMC Article
Vasic V, Barth K, Schmidt MHH
Int J Mol Sci 2019 Aug 31;20(17) doi: 10.3390/ijms20174272. PMID: 31480448Free PMC Article

Diagnosis

Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article
Feng Q, Ding Z
Curr Alzheimer Res 2020;17(3):297-309. doi: 10.2174/1567205017666200303105016. PMID: 32124697
Lloret A, Esteve D, Lloret MA, Cervera-Ferri A, Lopez B, Nepomuceno M, Monllor P
Int J Mol Sci 2019 Nov 6;20(22) doi: 10.3390/ijms20225536. PMID: 31698826Free PMC Article
Tamtaji OR, Heidari-Soureshjani R, Mirhosseini N, Kouchaki E, Bahmani F, Aghadavod E, Tajabadi-Ebrahimi M, Asemi Z
Clin Nutr 2019 Dec;38(6):2569-2575. Epub 2018 Dec 10 doi: 10.1016/j.clnu.2018.11.034. PMID: 30642737
Hebert LE, Weuve J, Scherr PA, Evans DA
Neurology 2013 May 7;80(19):1778-83. Epub 2013 Feb 6 doi: 10.1212/WNL.0b013e31828726f5. PMID: 23390181Free PMC Article

Therapy

Flo BK, Matziorinis AM, Skouras S, Sudmann TT, Gold C, Koelsch S
PLoS One 2022;17(6):e0270682. Epub 2022 Jun 30 doi: 10.1371/journal.pone.0270682. PMID: 35771851Free PMC Article
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE
JAMA Neurol 2021 Nov 1;78(11):1345-1354. doi: 10.1001/jamaneurol.2021.3310. PMID: 34570177Free PMC Article
Grossberg GT, Kohegyi E, Mergel V, Josiassen MK, Meulien D, Hobart M, Slomkowski M, Baker RA, McQuade RD, Cummings JL
Am J Geriatr Psychiatry 2020 Apr;28(4):383-400. Epub 2019 Oct 1 doi: 10.1016/j.jagp.2019.09.009. PMID: 31708380
Matsunaga S, Kishi T, Nomura I, Sakuma K, Okuya M, Ikuta T, Iwata N
Expert Opin Drug Saf 2018 Oct;17(10):1053-1061. Epub 2018 Sep 26 doi: 10.1080/14740338.2018.1524870. PMID: 30222469

Prognosis

Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W, Liu Y, Zhao Q, Peng M
Aging (Albany NY) 2023 Sep 2;15(17):9022-9040. doi: 10.18632/aging.205013. PMID: 37665672Free PMC Article
Alzheimers Dement 2021 Mar;17(3):327-406. Epub 2021 Mar 23 doi: 10.1002/alz.12328. PMID: 33756057
GBD 2016 Dementia Collaborators
Lancet Neurol 2019 Jan;18(1):88-106. Epub 2018 Nov 26 doi: 10.1016/S1474-4422(18)30403-4. PMID: 30497964Free PMC Article
Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B
Acta Neuropathol Commun 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2. PMID: 29422107Free PMC Article
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project
BMJ 2017 Dec 6;359:j5375. doi: 10.1136/bmj.j5375. PMID: 29212772Free PMC Article

Clinical prediction guides

Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W, Liu Y, Zhao Q, Peng M
Aging (Albany NY) 2023 Sep 2;15(17):9022-9040. doi: 10.18632/aging.205013. PMID: 37665672Free PMC Article
Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE
JAMA Neurol 2021 Nov 1;78(11):1345-1354. doi: 10.1001/jamaneurol.2021.3310. PMID: 34570177Free PMC Article
Bettcher BM, Tansey MG, Dorothée G, Heneka MT
Nat Rev Neurol 2021 Nov;17(11):689-701. Epub 2021 Sep 14 doi: 10.1038/s41582-021-00549-x. PMID: 34522039Free PMC Article
Kim B, Noh GO, Kim K
BMC Geriatr 2021 Mar 5;21(1):160. doi: 10.1186/s12877-021-02109-w. PMID: 33663416Free PMC Article
Honig LS, Vellas B, Woodward M, Boada M, Bullock R, Borrie M, Hager K, Andreasen N, Scarpini E, Liu-Seifert H, Case M, Dean RA, Hake A, Sundell K, Poole Hoffmann V, Carlson C, Khanna R, Mintun M, DeMattos R, Selzler KJ, Siemers E
N Engl J Med 2018 Jan 25;378(4):321-330. doi: 10.1056/NEJMoa1705971. PMID: 29365294

Recent systematic reviews

Barrio C, Arias-Sánchez S, Martín-Monzón I
Psychoneuroendocrinology 2022 Mar;137:105640. Epub 2021 Dec 17 doi: 10.1016/j.psyneuen.2021.105640. PMID: 34942539
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Borsa L, Dubois M, Sacco G, Lupi L
Int J Environ Res Public Health 2021 Sep 3;18(17) doi: 10.3390/ijerph18179312. PMID: 34501899Free PMC Article
van den Brink AC, Brouwer-Brolsma EM, Berendsen AAM, van de Rest O
Adv Nutr 2019 Nov 1;10(6):1040-1065. doi: 10.1093/advances/nmz054. PMID: 31209456Free PMC Article
Kishi T, Matsunaga S, Oya K, Nomura I, Ikuta T, Iwata N
J Alzheimers Dis 2017;60(2):401-425. doi: 10.3233/JAD-170424. PMID: 28922160

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