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Fusion Complex

MedGen UID:: 769497
•Concept ID:: C3640857
•: Finding

Definition

An electrocardiographic finding that occurs when electrical activation of the atria or ventricles occurs from two separate sites. This results in a P wave or QRS complex that displays merged characteristics of beats originating from the two different sites. (CDISC) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFusion Complex

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Cardiovascular finding
      - ECG finding
        Fusion Complex

Professional guidelines

PubMed

Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain.

Angius F, Smuts H, Rybkina K, Stelitano D, Eley B, Wilmshurst J, Ferren M, Lalande A, Mathieu C, Moscona A, Horvat B, Hashiguchi T, Porotto M, Hardie D
J Virol 2019 Feb 15;93(4) Epub 2019 Feb 5 doi: 10.1128/JVI.01700-18. PMID: 30487282 Free PMC Article

Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT.

Hungria EM, Bührer-Sékula S, Oliveira RM, Aderaldo LC, Pontes MAA, Cruz R, de Gonçalves HS, Penna MLF, Penna GO, Stefani MMA
Front Immunol 2018;9:915. Epub 2018 May 14 doi: 10.3389/fimmu.2018.00915. PMID: 29867930 Free PMC Article

Nationwide trends in the surgical management of lumbar spinal stenosis.

Bae HW, Rajaee SS, Kanim LE
Spine (Phila Pa 1976) 2013 May 15;38(11):916-26. doi: 10.1097/BRS.0b013e3182833e7c. PMID: 23324922

See all (3)

Recent clinical studies

Etiology

Challenges and advances in serological and molecular tests to aid leprosy diagnosis.

Lopes-Luz L, Saavedra DP, Fogaça MBT, Bührer-Sékula S, Stefani MMA
Exp Biol Med (Maywood) 2023 Nov;248(22):2083-2094. Epub 2023 Dec 7 doi: 10.1177/15353702231209422. PMID: 38059475 Free PMC Article

Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT.

Complex ankle arthrodesis using the Ilizarov method yields high rate of fusion.

Fragomen AT, Borst E, Schachter L, Lyman S, Rozbruch SR
Clin Orthop Relat Res 2012 Oct;470(10):2864-73. Epub 2012 Jul 10 doi: 10.1007/s11999-012-2470-9. PMID: 22777590 Free PMC Article

VAMP subfamilies identified by specific R-SNARE motifs.

Rossi V, Picco R, Vacca M, D'Esposito M, D'Urso M, Galli T, Filippini F
Biol Cell 2004 May;96(4):251-6. doi: 10.1016/j.biolcel.2003.12.009. PMID: 15145528

Mechanical and histologic evaluation of Collagraft in an ovine lumbar fusion model.

Walsh WR, Harrison J, Loefler A, Martin T, Van Sickle D, Brown MK, Sonnabend DH
Clin Orthop Relat Res 2000 Jun;(375):258-66. doi: 10.1097/00003086-200006000-00031. PMID: 10853177

See all (7)

Diagnosis

Challenges and advances in serological and molecular tests to aid leprosy diagnosis.

PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function.

Valtorta F, Benfenati F, Zara F, Meldolesi J
Trends Neurosci 2016 Oct;39(10):668-679. Epub 2016 Sep 10 doi: 10.1016/j.tins.2016.08.005. PMID: 27624551

SNARE requirements en route to exocytosis: from many to few.

Mohrmann R, Sørensen JB
J Mol Neurosci 2012 Oct;48(2):387-94. Epub 2012 Mar 17 doi: 10.1007/s12031-012-9744-2. PMID: 22427188

VAMP subfamilies identified by specific R-SNARE motifs.

Rossi V, Picco R, Vacca M, D'Esposito M, D'Urso M, Galli T, Filippini F
Biol Cell 2004 May;96(4):251-6. doi: 10.1016/j.biolcel.2003.12.009. PMID: 15145528

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.

Fasshauer D, Sutton RB, Brunger AT, Jahn R
Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15781-6. doi: 10.1073/pnas.95.26.15781. PMID: 9861047 Free PMC Article

See all (16)

Therapy

Peptide-Based Dual HIV and Coronavirus Entry Inhibitors.

Wang H, Wang C
Adv Exp Med Biol 2022;1366:87-100. doi: 10.1007/978-981-16-8702-0_6. PMID: 35412136

An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression.

Fujii R, Jochems C, Tritsch SR, Wong HC, Schlom J, Hodge JW
Cancer Immunol Immunother 2018 Apr;67(4):675-689. Epub 2018 Feb 1 doi: 10.1007/s00262-018-2121-4. PMID: 29392336 Free PMC Article

QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy.

Sweeney MO, Hellkamp AS, van Bommel RJ, Schalij MJ, Borleffs CJ, Bax JJ
Heart Rhythm 2014 May;11(5):806-13. Epub 2014 Jan 22 doi: 10.1016/j.hrthm.2014.01.021. PMID: 24462523

Complex ankle arthrodesis using the Ilizarov method yields high rate of fusion.

Fragomen AT, Borst E, Schachter L, Lyman S, Rozbruch SR
Clin Orthop Relat Res 2012 Oct;470(10):2864-73. Epub 2012 Jul 10 doi: 10.1007/s11999-012-2470-9. PMID: 22777590 Free PMC Article

Drug Insight: biological effects of botulinum toxin A in the lower urinary tract.

Chancellor MB, Fowler CJ, Apostolidis A, de Groat WC, Smith CP, Somogyi GT, Aoki KR
Nat Clin Pract Urol 2008 Jun;5(6):319-28. Epub 2008 May 6 doi: 10.1038/ncpuro1124. PMID: 18461049 Free PMC Article

See all (10)

Prognosis

Challenges and advances in serological and molecular tests to aid leprosy diagnosis.

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

Oliver SL, Xing Y, Chen DH, Roh SH, Pintilie GD, Bushnell DA, Sommer MH, Yang E, Carfi A, Chiu W, Arvin AM
PLoS Pathog 2021 Jan;17(1):e1008961. Epub 2021 Jan 7 doi: 10.1371/journal.ppat.1008961. PMID: 33411789 Free PMC Article

Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB 3rd
Acc Chem Res 2014 Apr 15;47(4):1228-37. Epub 2014 Feb 6 doi: 10.1021/ar4002735. PMID: 24502450 Free PMC Article

QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy.

Sweeney MO, Hellkamp AS, van Bommel RJ, Schalij MJ, Borleffs CJ, Bax JJ
Heart Rhythm 2014 May;11(5):806-13. Epub 2014 Jan 22 doi: 10.1016/j.hrthm.2014.01.021. PMID: 24462523

Complex ankle arthrodesis using the Ilizarov method yields high rate of fusion.

Fragomen AT, Borst E, Schachter L, Lyman S, Rozbruch SR
Clin Orthop Relat Res 2012 Oct;470(10):2864-73. Epub 2012 Jul 10 doi: 10.1007/s11999-012-2470-9. PMID: 22777590 Free PMC Article

See all (9)

Clinical prediction guides

Challenges and advances in serological and molecular tests to aid leprosy diagnosis.

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.

Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion.

Li M, Oh TJ, Fan H, Diao J, Zhang K
J Mol Biol 2020 Aug 7;432(17):4773-4782. Epub 2020 Jul 16 doi: 10.1016/j.jmb.2020.07.005. PMID: 32682743

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy.

Marcink TC, Yariv E, Rybkina K, Más V, Bovier FT, des Georges A, Greninger AL, Alabi CA, Porotto M, Ben-Tal N, Moscona A
mBio 2020 Feb 11;11(1) doi: 10.1128/mBio.03203-19. PMID: 32047132 Free PMC Article

QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy.

Sweeney MO, Hellkamp AS, van Bommel RJ, Schalij MJ, Borleffs CJ, Bax JJ
Heart Rhythm 2014 May;11(5):806-13. Epub 2014 Jan 22 doi: 10.1016/j.hrthm.2014.01.021. PMID: 24462523

See all (15)

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Fusion Complex

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Recent activity