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Stage 2B Neuroblastoma

MedGen UID:
769602
•Concept ID:
C3640962
•
Neoplastic Process
Synonym: Stage IIB Neuroblastoma

Definition

Localized tumor with or without complete gross excision, with ipsilateral nonadherent lymph nodes positive for tumor. Enlarged contralateral lymph nodes must be negative microscopically. (cancer.gov) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage 2B Neuroblastoma

Professional guidelines

PubMed

Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.
Patel A, Fischer C, Lin YC, Basu EM, Kushner BH, De Braganca K, Khakoo Y
Pediatr Blood Cancer 2020 Aug;67(8):e28319. Epub 2020 Jun 15 doi: 10.1002/pbc.28319. PMID: 32543116Free PMC Article
Successful treatment of infants with localized neuroblastoma based on their MYCN status.
Iehara T, Hamazaki M, Tajiri T, Kawano Y, Kaneko M, Ikeda H, Hosoi H, Sugimoto T, Sawada T; Japanese Infantile Neuroblastoma Cooperative Study Group
Int J Clin Oncol 2013 Jun;18(3):389-95. Epub 2012 Mar 2 doi: 10.1007/s10147-012-0391-y. PMID: 22383024
Successful management of low-stage neuroblastoma without adjuvant therapies: a comparison of two decades, 1972 through 1981 and 1982 through 1992, in a single institution.
Evans AE, Silber JH, Shpilsky A, D'Angio GJ
J Clin Oncol 1996 Sep;14(9):2504-10. doi: 10.1200/JCO.1996.14.9.2504. PMID: 8823329

Recent clinical studies

Etiology

The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma.
Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X
Pediatr Hematol Oncol 2022 May;39(4):343-356. Epub 2021 Nov 9 doi: 10.1080/08880018.2021.1995090. PMID: 34752187
Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.
Patel A, Fischer C, Lin YC, Basu EM, Kushner BH, De Braganca K, Khakoo Y
Pediatr Blood Cancer 2020 Aug;67(8):e28319. Epub 2020 Jun 15 doi: 10.1002/pbc.28319. PMID: 32543116Free PMC Article
Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.
El-Shazly SS, Hassan NM, Abdellateif MS, El Taweel MA, Abd-Elwahab N, Ebeid EN
Exp Mol Pathol 2019 Oct;110:104272. Epub 2019 Jun 18 doi: 10.1016/j.yexmp.2019.104272. PMID: 31220430
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, Papadakis V, Laureys G, Pearson AD, Ladenstein R, Burchill SA
J Clin Oncol 2014 Apr 1;32(10):1074-83. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.53.3604. PMID: 24590653

Diagnosis

The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma.
Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X
Pediatr Hematol Oncol 2022 May;39(4):343-356. Epub 2021 Nov 9 doi: 10.1080/08880018.2021.1995090. PMID: 34752187
Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.
Patel A, Fischer C, Lin YC, Basu EM, Kushner BH, De Braganca K, Khakoo Y
Pediatr Blood Cancer 2020 Aug;67(8):e28319. Epub 2020 Jun 15 doi: 10.1002/pbc.28319. PMID: 32543116Free PMC Article
The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.
El-Shazly SS, Hassan NM, Abdellateif MS, El Taweel MA, Abd-Elwahab N, Ebeid EN
Exp Mol Pathol 2019 Oct;110:104272. Epub 2019 Jun 18 doi: 10.1016/j.yexmp.2019.104272. PMID: 31220430
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, Papadakis V, Laureys G, Pearson AD, Ladenstein R, Burchill SA
J Clin Oncol 2014 Apr 1;32(10):1074-83. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.53.3604. PMID: 24590653
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Martucciello G, Lerone M, Bricco L, Tonini GP, Lombardi L, Del Rossi CG, Bernasconi S
Ital J Pediatr 2012 Mar 19;38:9. doi: 10.1186/1824-7288-38-9. PMID: 22429913Free PMC Article

Therapy

Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.
Patel A, Fischer C, Lin YC, Basu EM, Kushner BH, De Braganca K, Khakoo Y
Pediatr Blood Cancer 2020 Aug;67(8):e28319. Epub 2020 Jun 15 doi: 10.1002/pbc.28319. PMID: 32543116Free PMC Article
Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, Papadakis V, Laureys G, Pearson AD, Ladenstein R, Burchill SA
J Clin Oncol 2014 Apr 1;32(10):1074-83. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.53.3604. PMID: 24590653
Successful treatment of infants with localized neuroblastoma based on their MYCN status.
Iehara T, Hamazaki M, Tajiri T, Kawano Y, Kaneko M, Ikeda H, Hosoi H, Sugimoto T, Sawada T; Japanese Infantile Neuroblastoma Cooperative Study Group
Int J Clin Oncol 2013 Jun;18(3):389-95. Epub 2012 Mar 2 doi: 10.1007/s10147-012-0391-y. PMID: 22383024
Neuroblastoma in adolescents and adults: the Memorial Sloan-Kettering experience.
Kushner BH, Kramer K, LaQuaglia MP, Modak S, Cheung NK
Med Pediatr Oncol 2003 Dec;41(6):508-15. doi: 10.1002/mpo.10273. PMID: 14595707

Prognosis

The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma.
Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X
Pediatr Hematol Oncol 2022 May;39(4):343-356. Epub 2021 Nov 9 doi: 10.1080/08880018.2021.1995090. PMID: 34752187
Treatment and revaccination of children with paraneoplastic opsoclonus-myoclonus-ataxia syndrome and neuroblastoma: The Memorial Sloan Kettering experience.
Patel A, Fischer C, Lin YC, Basu EM, Kushner BH, De Braganca K, Khakoo Y
Pediatr Blood Cancer 2020 Aug;67(8):e28319. Epub 2020 Jun 15 doi: 10.1002/pbc.28319. PMID: 32543116Free PMC Article
Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
PHOX2B Is Associated with Neuroblastoma Cell Differentiation.
Yang L, Ke XX, Xuan F, Tan J, Hou J, Wang M, Cui H, Zhang Y
Cancer Biother Radiopharm 2016 Mar;31(2):44-51. Epub 2016 Feb 24 doi: 10.1089/cbr.2015.1952. PMID: 26910576
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Martucciello G, Lerone M, Bricco L, Tonini GP, Lombardi L, Del Rossi CG, Bernasconi S
Ital J Pediatr 2012 Mar 19;38:9. doi: 10.1186/1824-7288-38-9. PMID: 22429913Free PMC Article

Clinical prediction guides

The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma.
Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X
Pediatr Hematol Oncol 2022 May;39(4):343-356. Epub 2021 Nov 9 doi: 10.1080/08880018.2021.1995090. PMID: 34752187
The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.
El-Shazly SS, Hassan NM, Abdellateif MS, El Taweel MA, Abd-Elwahab N, Ebeid EN
Exp Mol Pathol 2019 Oct;110:104272. Epub 2019 Jun 18 doi: 10.1016/j.yexmp.2019.104272. PMID: 31220430
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
Viprey VF, Gregory WM, Corrias MV, Tchirkov A, Swerts K, Vicha A, Dallorso S, Brock P, Luksch R, Valteau-Couanet D, Papadakis V, Laureys G, Pearson AD, Ladenstein R, Burchill SA
J Clin Oncol 2014 Apr 1;32(10):1074-83. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.53.3604. PMID: 24590653
Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma.
Liontas A, Yeger H
Anticancer Res 2004 Mar-Apr;24(2B):987-98. PMID: 15161054
Survival from non-stage 4 neuroblastoma without cytotoxic therapy: an analysis of clinical and biological markers.
Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Ambros P, Ambros I, Ladanyi M, Eddy J, Bonilla MA, Gerald W
Eur J Cancer 1997 Oct;33(12):2117-20. doi: 10.1016/s0959-8049(97)00281-5. PMID: 9516865

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