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Compound Nevus

MedGen UID:
78058
•Concept ID:
C0259781
•
Neoplastic Process
Synonyms: Compound nevus; Compound nevus of skin; Compound Nevus of Skin; Compound Nevus of the Skin; Dermal and epidermal nevus
SNOMED CT: Compound nevus of skin (254805008); Compound nevus (49409001); Dermal and epidermal nevus (49409001)

Definition

A nevus composed of neoplastic melanocytes that infiltrate both the epidermis and the dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCompound Nevus

Professional guidelines

PubMed

Features, management, and outcomes of pediatric scalp melanomas.
Mologousis MA, Moustafa D, Hawryluk EB
Pediatr Dermatol 2024 Mar-Apr;41(2):266-269. Epub 2023 Dec 21 doi: 10.1111/pde.15507. PMID: 38128580
Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.
Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM
Ear Nose Throat J 2010 Nov;89(11):534-40. PMID: 21086277
Blue nevus: classical types and new related entities. A differential diagnostic review.
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522

Recent clinical studies

Etiology

Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.
de la Fouchardiere A, Tirode F, Castillo C, Buisson A, Boivin F, Macagno N, Pissaloux D
Am J Surg Pathol 2022 Aug 1;46(8):1106-1115. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001888. PMID: 35319526
Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.
Lee YJ, Lee C, Kim MK, Khwarg SI, Oh JY
Sci Rep 2019 Dec 3;9(1):18204. doi: 10.1038/s41598-019-54786-8. PMID: 31796811Free PMC Article
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.
Costea CF, Turliuc MD, Dimitriu G, Bogdănici CM, MoŢoc A, Chihaia MA, Dancă C, Cucu A, Cărăuleanu A, Dumitrescu N, Indrei L, Turliuc Ş
Rom J Morphol Embryol 2017;58(3):739-747. PMID: 29250649
The usefulness of c-Kit in the immunohistochemical assessment of melanocytic lesions.
Pilloni L, Bianco P, Difelice E, Cabras S, Castellanos ME, Atzori L, Ferreli C, Mulas P, Nemolato S, Faa G
Eur J Histochem 2011 Jun 7;55(2):e20. doi: 10.4081/ejh.2011.e20. PMID: 22193299Free PMC Article
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus.
Sherrill AM, Crespo G, Prakash AV, Messina JL
Am J Dermatopathol 2011 Feb;33(1):35-9. doi: 10.1097/DAD.0b013e3181e5dfa0. PMID: 21124206

Diagnosis

Targetoid haemosiderotic nevus: four cases and a literature review.
Zhang LW, Li Y, Wang WJ, Fu LX, Nie J, Lu YH, Chen T, Xu RH
Eur J Dermatol 2023 Jun 1;33(3):255-259. doi: 10.1684/ejd.2023.4481. PMID: 37594332
Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Estimating melanin location in the pigmented skin lesions by hue-saturation-lightness color space values of dermoscopic images.
Sakai H, Ando Y, Ikinaga K, Tanaka M
J Dermatol 2017 May;44(5):490-498. doi: 10.1111/1346-8138.13725. PMID: 28447351
Oral compound nevus.
Cardoso LB, Consalaro A, da Silva Santos PS, da Silva Sampieri MB, Tinoco-Araújo JE
Dermatol Online J 2014 Feb 18;20(2) PMID: 24612575
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus.
Sherrill AM, Crespo G, Prakash AV, Messina JL
Am J Dermatopathol 2011 Feb;33(1):35-9. doi: 10.1097/DAD.0b013e3181e5dfa0. PMID: 21124206

Therapy

Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices-Case Report and Review of the Literature.
Nurla LA, Wafi G, Tatar R, Dorobanțu AM, Chivu M, Popa LG, Giurcăneanu C, Orzan OA
Medicina (Kaunas) 2024 Jan 21;60(1) doi: 10.3390/medicina60010187. PMID: 38276066Free PMC Article
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
Staged Mosaic Punching Excision of a Kissing Nevus on the Eyelid.
Cho HJ, Lee W, Jeon MK, Park JO, Yang EJ
Aesthetic Plast Surg 2019 Jun;43(3):652-657. Epub 2019 Apr 1 doi: 10.1007/s00266-019-01362-0. PMID: 30937473
Hyperpigmented scar due to minocycline therapy.
Patterson JW, Wilson B, Wick MR, Heath C
Cutis 2004 Nov;74(5):293-8. PMID: 15605966
Pseudomelanoma after laser therapy.
Hwang K, Lee WJ, Lee SI
Ann Plast Surg 2002 May;48(5):562-4. doi: 10.1097/00000637-200205000-00021. PMID: 11981202

Prognosis

Clinical and dermoscopic (in vivo and ex vivo) predictors of recurrent nevi.
Heck R, Ferrari T, Cartell A, Bakos RM
Eur J Dermatol 2019 Apr 1;29(2):179-184. doi: 10.1684/ejd.2019.3530. PMID: 30907363
Neurocutaneous melanosis in children with giant congenital melanocytic nevi.
Bekiesinska-Figatowska M, Szczygielski O, Boczar M, Madzik J, Klepacka T, Michalak E, Romaniuk-Doroszewska A, Uliasz M, Peczkowski P, Sawicka E
Clin Imaging 2014 Mar-Apr;38(2):79-84. Epub 2013 Oct 16 doi: 10.1016/j.clinimag.2013.10.001. PMID: 24239041
Pigmented nevus of the external auditory canal.
Lee FP
Otolaryngol Head Neck Surg 2006 Jul;135(1):124-8. doi: 10.1016/j.otohns.2005.11.027. PMID: 16815196
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.
Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA
Arch Ophthalmol 2004 Feb;122(2):167-75. doi: 10.1001/archopht.122.2.167. PMID: 14769591
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267

Clinical prediction guides

Targetoid haemosiderotic nevus: four cases and a literature review.
Zhang LW, Li Y, Wang WJ, Fu LX, Nie J, Lu YH, Chen T, Xu RH
Eur J Dermatol 2023 Jun 1;33(3):255-259. doi: 10.1684/ejd.2023.4481. PMID: 37594332
Dermatoscopy and Reflective Confocal Microscopy for Facial Seborrheic Keratosis, Verruca Plana, and Nevus Pigmentosus.
Lu Q, Wang S, Wu T, Jiang G
J Coll Physicians Surg Pak 2021 Apr;31(4):450-454. doi: 10.29271/jcpsp.2021.04.450. PMID: 33866733
Clinical and dermoscopic (in vivo and ex vivo) predictors of recurrent nevi.
Heck R, Ferrari T, Cartell A, Bakos RM
Eur J Dermatol 2019 Apr 1;29(2):179-184. doi: 10.1684/ejd.2019.3530. PMID: 30907363
Estimating melanin location in the pigmented skin lesions by hue-saturation-lightness color space values of dermoscopic images.
Sakai H, Ando Y, Ikinaga K, Tanaka M
J Dermatol 2017 May;44(5):490-498. doi: 10.1111/1346-8138.13725. PMID: 28447351
Brown cornea.
Steiber Z, Ehlers N, Heegaard S, Hjortdal J, Berta A, Prause JU
Graefes Arch Clin Exp Ophthalmol 2008 Apr;246(4):537-41. Epub 2008 Jan 12 doi: 10.1007/s00417-007-0736-9. PMID: 18193447

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