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Subchorionic hematoma

MedGen UID:
782276
•Concept ID:
C3495808
•
Pathologic Function
Synonyms: Subchorial Thrombus; Subchorionic Hematoma
SNOMED CT: Subchorionic hematoma (609204004)

Definition

A focus of subchorial thrombus variably extending into the intervillous space, often with peripheral villous compression. The clot may be wholly or minimally laminated reflecting age. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubchorionic hematoma

Professional guidelines

PubMed

Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases.
Giorgione V, Cavoretto P, Cormio G, Valsecchi L, Vimercati A, De Gennaro A, Rabaiotti E, Candiani M, Mangili G
Gynecol Obstet Invest 2017;82(4):404-409. Epub 2016 Aug 13 doi: 10.1159/000448139. PMID: 27522447
ACR appropriateness Criteria® second and third trimester bleeding.
Podrasky AE, Javitt MC, Glanc P, Dubinsky T, Harisinghani MG, Harris RD, Khati NJ, Mitchell DG, Pandharipande PV, Pannu HK, Shipp TD, Siegel CL, Simpson L, Wall DJ, Wong-You-Cheong JJ, Zelop CM
Ultrasound Q 2013 Dec;29(4):293-301. doi: 10.1097/RUQ.0000000000000044. PMID: 24263752
Subchorionic hemorrhage treatment with dydrogesterone.
Pelinescu-Onciul D
Gynecol Endocrinol 2007 Oct;23 Suppl 1:77-81. doi: 10.1080/09513590701584741. PMID: 17943544

Recent clinical studies

Etiology

Associations between the size and duration of asymptomatic subchorionic hematoma and pregnancy outcomes in women with singleton pregnancies.
Pan S, Lan Y, Zhou Y, Chen B, Zhou F, Dai D, Hua Y
BMC Pregnancy Childbirth 2023 Aug 2;23(1):555. doi: 10.1186/s12884-023-05831-y. PMID: 37532977Free PMC Article
Subchorionic hematoma and risk of preterm delivery: a systematic review and meta-analysis.
Yan X, Xu H, Li J, Xu Z, Niu Y, Wang Y
Am J Obstet Gynecol MFM 2023 Jan;5(1):100791. Epub 2022 Nov 1 doi: 10.1016/j.ajogmf.2022.100791. PMID: 36328350
Outcomes of subchorionic hematoma-affected pregnancies in the infertile population.
Inman ER, Miranian DC, Stevenson MJ, Kobernik EK, Moravek MB, Schon SB
Int J Gynaecol Obstet 2022 Dec;159(3):743-750. Epub 2022 Mar 14 doi: 10.1002/ijgo.14162. PMID: 35212401Free PMC Article
Placental abruption and hemorrhage-review of imaging appearance.
Fadl SA, Linnau KF, Dighe MK
Emerg Radiol 2019 Feb;26(1):87-97. Epub 2018 Aug 29 doi: 10.1007/s10140-018-1638-3. PMID: 30159815
Subchorionic hematoma: a review.
Pearlstone M, Baxi L
Obstet Gynecol Surv 1993 Feb;48(2):65-8. PMID: 8437776

Diagnosis

Associations between the size and duration of asymptomatic subchorionic hematoma and pregnancy outcomes in women with singleton pregnancies.
Pan S, Lan Y, Zhou Y, Chen B, Zhou F, Dai D, Hua Y
BMC Pregnancy Childbirth 2023 Aug 2;23(1):555. doi: 10.1186/s12884-023-05831-y. PMID: 37532977Free PMC Article
Subchorionic hematoma and risk of preterm delivery: a systematic review and meta-analysis.
Yan X, Xu H, Li J, Xu Z, Niu Y, Wang Y
Am J Obstet Gynecol MFM 2023 Jan;5(1):100791. Epub 2022 Nov 1 doi: 10.1016/j.ajogmf.2022.100791. PMID: 36328350
Chronic abruption-oligohydramnios sequence (CAOS) revisited: possible implication of premature rupture of membranes.
Chigusa Y, Mogami H, Minamiguchi S, Kido A, Ishida A, Kurata Y, Yasuda E, Kawasaki K, Horie A, Yamaguchi K, Mandai M, Kondoh E
J Matern Fetal Neonatal Med 2022 Dec;35(25):6894-6900. Epub 2021 May 20 doi: 10.1080/14767058.2021.1929159. PMID: 34016009
Placental abruption and hemorrhage-review of imaging appearance.
Fadl SA, Linnau KF, Dighe MK
Emerg Radiol 2019 Feb;26(1):87-97. Epub 2018 Aug 29 doi: 10.1007/s10140-018-1638-3. PMID: 30159815
Perinatal outcomes in women with subchorionic hematoma: a systematic review and meta-analysis.
Tuuli MG, Norman SM, Odibo AO, Macones GA, Cahill AG
Obstet Gynecol 2011 May;117(5):1205-1212. doi: 10.1097/AOG.0b013e31821568de. PMID: 21508763

Therapy

Impact of subchorionic hematoma on pregnancy outcomes in women with recurrent pregnancy loss.
Fu Z, Ding X, Wei D, Li J, Cang R, Li X
Biomol Biomed 2023 Feb 1;23(1):170-175. doi: 10.17305/bjbms.2022.7705. PMID: 35988056Free PMC Article
Association between first-trimester subchorionic hematoma detected at 6-8 weeks of gestation and pregnancy outcomes after fresh embryo transfers: a propensity score-matching cohort study.
Yin R, Wang K, Li L, Dang Y, Wang B, Sheng Y, Ma Z, Sun M
Arch Gynecol Obstet 2022 Dec;306(6):2167-2175. Epub 2022 Sep 16 doi: 10.1007/s00404-022-06775-y. PMID: 36112208
Clinicopathologic Study of Placentas From Women With a Fontan Circulation.
Yokouchi-Konishi T, Ohta-Ogo K, Kamiya CA, Shionoiri T, Nakanishi A, Iwanaga N, Ohuchi H, Kurosaki K, Ichikawa H, Noguchi T, Ishibashi-Ueda H, Yoshimatsu J
Circ J 2021 Dec 24;86(1):138-146. Epub 2021 Sep 8 doi: 10.1253/circj.CJ-21-0133. PMID: 34497162
Resolution of subchorionic hematoma and symptoms of threatened miscarriage using vaginal alpha lipoic acid or progesterone: clinical evidences.
Costantino M, Guaraldi C, Costantino D
Eur Rev Med Pharmacol Sci 2016 Apr;20(8):1656-63. PMID: 27160142
Perinatal outcomes in women with subchorionic hematoma: a systematic review and meta-analysis.
Tuuli MG, Norman SM, Odibo AO, Macones GA, Cahill AG
Obstet Gynecol 2011 May;117(5):1205-1212. doi: 10.1097/AOG.0b013e31821568de. PMID: 21508763

Prognosis

Relationship between the Volume Ratio of Subchorionic Hematoma to Gestation SAC in First-trimester and Pregnancy Outcome of Patients with Threatened Abortion.
Wang X, Shi W, Shi J, Ding Y, Yu Z, Zhang H
J Coll Physicians Surg Pak 2022 Nov;32(11):1415-1419. doi: 10.29271/jcpsp.2022.11.1415. PMID: 36377007
Subchorionic Hematoma Volume Measured by Virtual Organ Computer-Aided Analysis in the Prediction of First-Trimester Pregnancy Outcome.
Xu C, Wang W, Yang B, Zhu M
Ultrasound Q 2022 Dec 1;38(4):291-296. Epub 2022 Oct 10 doi: 10.1097/RUQ.0000000000000627. PMID: 36223480
Resolution of subchorionic hematoma and symptoms of threatened miscarriage using vaginal alpha lipoic acid or progesterone: clinical evidences.
Costantino M, Guaraldi C, Costantino D
Eur Rev Med Pharmacol Sci 2016 Apr;20(8):1656-63. PMID: 27160142
First trimester bleeding evaluation.
Dogra V, Paspulati RM, Bhatt S
Ultrasound Q 2005 Jun;21(2):69-85; quiz 149-50, 153-4. PMID: 15905817
Subchorionic hematoma: a review.
Pearlstone M, Baxi L
Obstet Gynecol Surv 1993 Feb;48(2):65-8. PMID: 8437776

Clinical prediction guides

Relationship between the Volume Ratio of Subchorionic Hematoma to Gestation SAC in First-trimester and Pregnancy Outcome of Patients with Threatened Abortion.
Wang X, Shi W, Shi J, Ding Y, Yu Z, Zhang H
J Coll Physicians Surg Pak 2022 Nov;32(11):1415-1419. doi: 10.29271/jcpsp.2022.11.1415. PMID: 36377007
Subchorionic Hematoma Volume Measured by Virtual Organ Computer-Aided Analysis in the Prediction of First-Trimester Pregnancy Outcome.
Xu C, Wang W, Yang B, Zhu M
Ultrasound Q 2022 Dec 1;38(4):291-296. Epub 2022 Oct 10 doi: 10.1097/RUQ.0000000000000627. PMID: 36223480
Association between first-trimester subchorionic hematoma detected at 6-8 weeks of gestation and pregnancy outcomes after fresh embryo transfers: a propensity score-matching cohort study.
Yin R, Wang K, Li L, Dang Y, Wang B, Sheng Y, Ma Z, Sun M
Arch Gynecol Obstet 2022 Dec;306(6):2167-2175. Epub 2022 Sep 16 doi: 10.1007/s00404-022-06775-y. PMID: 36112208
Alpha Lipoic Acid (ALA) effects on subchorionic hematoma: preliminary clinical results.
Porcaro G, Brillo E, Giardina I, Di Iorio R
Eur Rev Med Pharmacol Sci 2015 Sep;19(18):3426-32. PMID: 26439038
First trimester bleeding evaluation.
Dogra V, Paspulati RM, Bhatt S
Ultrasound Q 2005 Jun;21(2):69-85; quiz 149-50, 153-4. PMID: 15905817

Recent systematic reviews

Subchorionic hematoma and risk of preterm delivery: a systematic review and meta-analysis.
Yan X, Xu H, Li J, Xu Z, Niu Y, Wang Y
Am J Obstet Gynecol MFM 2023 Jan;5(1):100791. Epub 2022 Nov 1 doi: 10.1016/j.ajogmf.2022.100791. PMID: 36328350
Perinatal outcomes in women with subchorionic hematoma: a systematic review and meta-analysis.
Tuuli MG, Norman SM, Odibo AO, Macones GA, Cahill AG
Obstet Gynecol 2011 May;117(5):1205-1212. doi: 10.1097/AOG.0b013e31821568de. PMID: 21508763

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