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Ulceration of large intestine

MedGen UID:
78628
Concept ID:
C0267491
Disease or Syndrome
Synonyms: Colonic Ulcer; Colonic ulcer; Ulceration of colon
SNOMED CT: Ulceration of large intestine (235766003); Ulceration of colon (46040000); Colonic ulcer (46040000)

Definition

A circumscribed inflammatory and necrotic erosive lesion in the mucosa surface of the colon. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUlceration of large intestine

Professional guidelines

PubMed

Feuerstein JD, Isaacs KL, Schneider Y, Siddique SM, Falck-Ytter Y, Singh S; AGA Institute Clinical Guidelines Committee
Gastroenterology 2020 Apr;158(5):1450-1461. Epub 2020 Jan 13 doi: 10.1053/j.gastro.2020.01.006. PMID: 31945371Free PMC Article
Keshteli AH, Madsen KL, Dieleman LA
Nutrients 2019 Jun 30;11(7) doi: 10.3390/nu11071498. PMID: 31262022Free PMC Article
Spiceland CM, Lodhia N
World J Gastroenterol 2018 Sep 21;24(35):4014-4020. doi: 10.3748/wjg.v24.i35.4014. PMID: 30254405Free PMC Article

Recent clinical studies

Etiology

Adams SM, Close ED, Shreenath AP
Am Fam Physician 2022 Apr 1;105(4):406-411. PMID: 35426646
Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A
Cell 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029. PMID: 31348891Free PMC Article
Keshteli AH, Madsen KL, Dieleman LA
Nutrients 2019 Jun 30;11(7) doi: 10.3390/nu11071498. PMID: 31262022Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Rietdijk ST, D'Haens GR
Expert Rev Clin Pharmacol 2014 Jul;7(4):423-30. Epub 2014 May 6 doi: 10.1586/17512433.2014.911084. PMID: 24802046

Diagnosis

Loftis C, White R, Dulgheru EC
Mod Rheumatol Case Rep 2022 Jun 24;6(2):189-193. doi: 10.1093/mrcr/rxab043. PMID: 34791372
Lightner AL
Dis Colon Rectum 2020 Aug;63(8):1023-1026. doi: 10.1097/DCR.0000000000001748. PMID: 32692067
Neurath MF, Leppkes M
Semin Immunopathol 2019 Nov;41(6):747-756. Epub 2019 Jul 5 doi: 10.1007/s00281-019-00751-6. PMID: 31278430
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Han J, Lee SH, Giebisch G, Wang T
Gut Liver 2016 Nov 15;10(6):881-889. doi: 10.5009/gnl15414. PMID: 27784845Free PMC Article

Therapy

Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A
Cell 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029. PMID: 31348891Free PMC Article
Keshteli AH, Madsen KL, Dieleman LA
Nutrients 2019 Jun 30;11(7) doi: 10.3390/nu11071498. PMID: 31262022Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Kedia S, Das P, Madhusudhan KS, Dattagupta S, Sharma R, Sahni P, Makharia G, Ahuja V
World J Gastroenterol 2019 Jan 28;25(4):418-432. doi: 10.3748/wjg.v25.i4.418. PMID: 30700939Free PMC Article

Prognosis

Hong JT, Kim ER, Park SW, Kim JW, Hong SN, Chang DK, Kim YH, Cho JH
Gut Liver 2021 Jan 15;15(1):77-84. doi: 10.5009/gnl19288. PMID: 32062874Free PMC Article
Pravda J
Discov Med 2019 May;27(149):197-200. PMID: 31361982
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Antonelli E, Villanacci V, Bassotti G
World J Gastroenterol 2018 Dec 21;24(47):5322-5330. doi: 10.3748/wjg.v24.i47.5322. PMID: 30598577Free PMC Article
Limsrivilai J, Shreiner AB, Pongpaibul A, Laohapand C, Boonanuwat R, Pausawasdi N, Pongprasobchai S, Manatsathit S, Higgins PD
Am J Gastroenterol 2017 Mar;112(3):415-427. Epub 2017 Jan 3 doi: 10.1038/ajg.2016.529. PMID: 28045023Free PMC Article

Clinical prediction guides

Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P, Moser D, Haller F, Hof F, Beer A, Orgler E, Frick A, Khare V, Evstatiev R, Strohmaier S, Primas C, Dolak W, Köcher T, Klavins K, Rath T, Neurath MF, Berry D, Makristathis A, Muttenthaler M, Gasche C
Gastroenterology 2021 Oct;161(4):1245-1256.e20. Epub 2021 Jun 17 doi: 10.1053/j.gastro.2021.06.024. PMID: 34146566Free PMC Article
Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A
Cell 2019 Jul 25;178(3):714-730.e22. doi: 10.1016/j.cell.2019.06.029. PMID: 31348891Free PMC Article
Gajendran M, Loganathan P, Jimenez G, Catinella AP, Ng N, Umapathy C, Ziade N, Hashash JG
Dis Mon 2019 Dec;65(12):100851. Epub 2019 Mar 2 doi: 10.1016/j.disamonth.2019.02.004. PMID: 30837080
Kedia S, Das P, Madhusudhan KS, Dattagupta S, Sharma R, Sahni P, Makharia G, Ahuja V
World J Gastroenterol 2019 Jan 28;25(4):418-432. doi: 10.3748/wjg.v25.i4.418. PMID: 30700939Free PMC Article
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold MD, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L
Gut 2017 Jan;66(1):43-49. Epub 2015 Oct 13 doi: 10.1136/gutjnl-2015-310187. PMID: 26464414

Recent systematic reviews

Al-Rashedy M, Mukherjee T, Askari A, Gurjar S
Arab J Gastroenterol 2023 May;24(2):79-84. Epub 2023 Feb 20 doi: 10.1016/j.ajg.2023.01.007. PMID: 36813579
Gordon IO, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert ME, Valasek MA, Mao R, Li J, Harpaz N, Borralho P, Pai RK, Odze R, Feakins R, Parker CE, Guizzetti L, Nguyen T, Shackelton LM, Sandborn WJ, Jairath V, Baker M, Bruining D, Fletcher JG, Feagan BG, Pai RK, Rieder F; Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium
Gut 2022 Mar;71(3):479-486. Epub 2021 May 5 doi: 10.1136/gutjnl-2021-324374. PMID: 33952604Free PMC Article
Forootan M, Darvishi M
Medicine (Baltimore) 2018 May;97(18):e0565. doi: 10.1097/MD.0000000000010565. PMID: 29718850Free PMC Article
Gould NJ, Davidson KL, Nwokolo CU, Arasaradnam RP
Epigenomics 2016 May;8(5):667-84. Epub 2016 Apr 20 doi: 10.2217/epi-2016-0006. PMID: 27096966
Singh S, Sharma PK, Loftus EV Jr, Pardi DS
Aliment Pharmacol Ther 2013 May;37(9):867-75. Epub 2013 Mar 11 doi: 10.1111/apt.12274. PMID: 23480145

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