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Localized Extrahepatic Bile Duct Carcinoma

MedGen UID:
78886
•Concept ID:
C0278810
•
Neoplastic Process
Synonyms: Localized Cancer of Extrahepatic Bile Duct; Localized Cancer of the Extrahepatic Bile Duct; Localized Extrahepatic Bile Duct Cancer

Definition

A carcinoma that arises from the extrahepatic bile ducts and it has not spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Extrahepatic Bile Duct Carcinoma

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Management of primary sclerosing cholangitis and its complications: an algorithmic approach.
Prokopič M, Beuers U
Hepatol Int 2021 Feb;15(1):6-20. Epub 2020 Dec 30 doi: 10.1007/s12072-020-10118-x. PMID: 33377990Free PMC Article

Recent clinical studies

Etiology

Management of primary sclerosing cholangitis and its complications: an algorithmic approach.
Prokopič M, Beuers U
Hepatol Int 2021 Feb;15(1):6-20. Epub 2020 Dec 30 doi: 10.1007/s12072-020-10118-x. PMID: 33377990Free PMC Article
Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma.
Akita M, Ajiki T, Ueno K, Tsugawa D, Tanaka M, Kido M, Toyama H, Fukumoto T
Hepatobiliary Pancreat Dis Int 2020 Apr;19(2):147-152. Epub 2020 Jan 30 doi: 10.1016/j.hbpd.2020.01.002. PMID: 32037277
Approaches and Outcomes to Distal Cholangiocarcinoma.
Lee RM, Maithel SK
Surg Oncol Clin N Am 2019 Oct;28(4):631-643. doi: 10.1016/j.soc.2019.06.014. PMID: 31472910
Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Diagnosis

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Management of primary sclerosing cholangitis and its complications: an algorithmic approach.
Prokopič M, Beuers U
Hepatol Int 2021 Feb;15(1):6-20. Epub 2020 Dec 30 doi: 10.1007/s12072-020-10118-x. PMID: 33377990Free PMC Article
Surgical Considerations of Hilar Cholangiocarcinoma.
Anderson B, Doyle MBM
Surg Oncol Clin N Am 2019 Oct;28(4):601-617. Epub 2019 Aug 2 doi: 10.1016/j.soc.2019.06.003. PMID: 31472908
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Therapy

Approaches and Outcomes to Distal Cholangiocarcinoma.
Lee RM, Maithel SK
Surg Oncol Clin N Am 2019 Oct;28(4):631-643. doi: 10.1016/j.soc.2019.06.014. PMID: 31472910
Radiation therapy in cholangiocellular carcinomas.
Brunner TB, Seufferlein T
Best Pract Res Clin Gastroenterol 2016 Aug;30(4):593-602. Epub 2016 Aug 24 doi: 10.1016/j.bpg.2016.08.003. PMID: 27644907
Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Surgical Considerations of Hilar Cholangiocarcinoma.
Anderson B, Doyle MBM
Surg Oncol Clin N Am 2019 Oct;28(4):601-617. Epub 2019 Aug 2 doi: 10.1016/j.soc.2019.06.003. PMID: 31472908
Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Clinical prediction guides

Hepatoid carcinoma and related entities of the extrahepatic bile duct: A clinicopathological study of four cases.
Okura K, Esaki M, Nara S, Ban D, Takamoto T, Shimada K, Hiraoka N
Pathol Int 2022 Jun;72(6):332-342. Epub 2022 Apr 26 doi: 10.1111/pin.13226. PMID: 35472251
Management of primary sclerosing cholangitis and its complications: an algorithmic approach.
Prokopič M, Beuers U
Hepatol Int 2021 Feb;15(1):6-20. Epub 2020 Dec 30 doi: 10.1007/s12072-020-10118-x. PMID: 33377990Free PMC Article
Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma.
Akita M, Ajiki T, Ueno K, Tsugawa D, Tanaka M, Kido M, Toyama H, Fukumoto T
Hepatobiliary Pancreat Dis Int 2020 Apr;19(2):147-152. Epub 2020 Jan 30 doi: 10.1016/j.hbpd.2020.01.002. PMID: 32037277
Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Hong TS, Wo JY, Yeap BY, Ben-Josef E, McDonnell EI, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Goyal L, Murphy JE, Javle MM, Wolfgang JA, Drapek LC, Arellano RS, Mamon HJ, Mullen JT, Yoon SS, Tanabe KK, Ferrone CR, Ryan DP, DeLaney TF, Crane CH, Zhu AX
J Clin Oncol 2016 Feb 10;34(5):460-8. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.2710. PMID: 26668346Free PMC Article
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Recent systematic reviews

Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Abdel-Rahman O, Elsayed Z, Elhalawani H
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD011746. doi: 10.1002/14651858.CD011746.pub2. PMID: 29624208Free PMC Article
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873
Review of the investigation and surgical management of resectable ampullary adenocarcinoma.
Askew J, Connor S
HPB (Oxford) 2013 Nov;15(11):829-38. Epub 2013 Jan 10 doi: 10.1111/hpb.12038. PMID: 23458317Free PMC Article
Current therapy of hilar cholangiocarcinoma.
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465

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