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Invasive malignant thymoma

MedGen UID:
78892
•Concept ID:
C0278846
•
Neoplastic Process
Synonyms: Infiltrating Thymoma; infiltrating thymoma; Invasive Malignant Thymoma; invasive malignant thymoma; Invasive Thymoma; Malignant Thymoma, Invasive; malignant thymoma, invasive; Thymoma Malignant Invasive; thymoma malignant invasive
 
Monarch Initiative: MONDO:0002592

Definition

A thymoma of any morphologic type that extends beyond the capsule and infiltrates the surrounding tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive malignant thymoma

Professional guidelines

PubMed

Surgical management of thymic epithelial tumors.
Shintani Y, Funaki S, Ose N, Kanou T, Fukui E, Kimura K, Minami M
Surg Today 2021 Mar;51(3):331-339. Epub 2020 Jul 10 doi: 10.1007/s00595-020-02070-y. PMID: 32647929
Thymoma: current diagnosis and treatment.
Detterbeck FC, Zeeshan A
Chin Med J (Engl) 2013;126(11):2186-91. PMID: 23769581
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thymomas and Thymic Carcinomas, 2023

Recent clinical studies

Etiology

Incidental locally infiltrating malignant thymoma and coronary artery bypass surgery-excision should always be considered.
Mirsadraee S, Shah SS, Kumar B, Kaul P
J Card Surg 2005 May-Jun;20(3):291-2. doi: 10.1111/j.1540-8191.2005.200455.x. PMID: 15854100
Thymoma--report of 71 cases and a review.
Verstandig AG, Epstein DM, Miller WT Jr, Aronchik JA, Gefter WB, Miller WT
Crit Rev Diagn Imaging 1992;33(3):201-30. PMID: 1571088
Aggressive surgical approach for drug-free remission from myasthenia gravis.
Fischer JE, Grinvalski HT, Nussbaum MS, Sayers HJ, Cole RE, Samaha FJ
Ann Surg 1987 May;205(5):496-503. doi: 10.1097/00000658-198705000-00007. PMID: 3579398Free PMC Article

Diagnosis

Myasthenia gravis associated with invasive malignant thymoma: two case reports and a review of the literature.
Beydoun SR, Gong H, Ashikian N, Rison RA
J Med Case Rep 2014 Oct 13;8:340. doi: 10.1186/1752-1947-8-340. PMID: 25312448Free PMC Article
Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation.
Bagga S, Bloch EM
Clin Nucl Med 2006 Oct;31(10):614-6. doi: 10.1097/01.rlu.0000238258.33680.ec. PMID: 16985366
Incidental locally infiltrating malignant thymoma and coronary artery bypass surgery-excision should always be considered.
Mirsadraee S, Shah SS, Kumar B, Kaul P
J Card Surg 2005 May-Jun;20(3):291-2. doi: 10.1111/j.1540-8191.2005.200455.x. PMID: 15854100
Severe T- and B-cell immune deficiency associated with malignant thymoma.
Yel L, Liao O, Lin F, Gupta S
Ann Allergy Asthma Immunol 2003 Nov;91(5):501-5. doi: 10.1016/S1081-1206(10)61522-0. PMID: 14692437
Biochemical characterization of thymic hormones in thymoma tissues.
Low TL
Thymus 1990 Mar;15(2):93-105. PMID: 2333664

Therapy

Incidental locally infiltrating malignant thymoma and coronary artery bypass surgery-excision should always be considered.
Mirsadraee S, Shah SS, Kumar B, Kaul P
J Card Surg 2005 May-Jun;20(3):291-2. doi: 10.1111/j.1540-8191.2005.200455.x. PMID: 15854100
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy.
Dy C, Calvo FA, Mindán JP, Aparicio LA, Algarra SM, Gil A, González F, Harguindey S
J Clin Oncol 1988 Mar;6(3):536-42. doi: 10.1200/JCO.1988.6.3.536. PMID: 2450971

Prognosis

Myasthenia gravis associated with invasive malignant thymoma: two case reports and a review of the literature.
Beydoun SR, Gong H, Ashikian N, Rison RA
J Med Case Rep 2014 Oct 13;8:340. doi: 10.1186/1752-1947-8-340. PMID: 25312448Free PMC Article
Incidental locally infiltrating malignant thymoma and coronary artery bypass surgery-excision should always be considered.
Mirsadraee S, Shah SS, Kumar B, Kaul P
J Card Surg 2005 May-Jun;20(3):291-2. doi: 10.1111/j.1540-8191.2005.200455.x. PMID: 15854100
Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine, and bleomycin therapy.
Dy C, Calvo FA, Mindán JP, Aparicio LA, Algarra SM, Gil A, González F, Harguindey S
J Clin Oncol 1988 Mar;6(3):536-42. doi: 10.1200/JCO.1988.6.3.536. PMID: 2450971

Clinical prediction guides

Cardiovascular involvement by invasive thymomas.
Shin MS, Witten DM, Han SY, Perrott WW
J Surg Oncol 1977;9(2):189-202. doi: 10.1002/jso.2930090213. PMID: 865126

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thymomas and Thymic Carcinomas, 2023

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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