U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypercortisolism

MedGen UID:
7899
•Concept ID:
C0001622
•
Disease or Syndrome
Synonyms: Adrenocortical hyperfunction; Hyperadrenalism; Overproduction of cortisol
SNOMED CT: Disorder of corticoadrenal overactivity (275437005); Adrenocortical hyperfunction (275437005); Hypercortisolism (47270006); Overproduction of cortisol (47270006); Hypercorticism (47270006)
 
Monarch Initiative: MONDO:0006640

Definition

Abnormally high level of cortisol in the blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypercortisolism

Professional guidelines

PubMed

Cushing's syndrome: Treatment and new therapeutic approaches.
Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's Syndrome: Screening and Diagnosis.
Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

Recent clinical studies

Etiology

Pharmacological Treatment of Cushing's Syndrome.
Castinetti F
Arch Med Res 2023 Dec;54(8):102908. Epub 2023 Nov 15 doi: 10.1016/j.arcmed.2023.102908. PMID: 37977919
Skeletal Fragility in Endogenous Hypercortisolism.
Mazziotti G, Delgado A, Maffezzoni F, Formenti A, Giustina A
Front Horm Res 2016;46:66-73. Epub 2016 May 17 doi: 10.1159/000443866. PMID: 27210111
Cushing's Syndrome: Screening and Diagnosis.
Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717
Adrenal incidentaloma.
Arnaldi G, Boscaro M
Best Pract Res Clin Endocrinol Metab 2012 Aug;26(4):405-19. Epub 2012 May 22 doi: 10.1016/j.beem.2011.12.006. PMID: 22863384
Side effects of corticosteroid therapy.
Buchman AL
J Clin Gastroenterol 2001 Oct;33(4):289-94. doi: 10.1097/00004836-200110000-00006. PMID: 11588541

Diagnosis

Cushing Syndrome: A Review.
Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427
Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Cushing's syndrome: Treatment and new therapeutic approaches.
Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797
Diagnosis of Cushing's Syndrome in the Modern Era.
Nieman LK
Endocrinol Metab Clin North Am 2018 Jun;47(2):259-273. doi: 10.1016/j.ecl.2018.02.001. PMID: 29754631
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483

Therapy

Cushing's disease: adrenal steroidogenesis inhibitors.
Pivonello R, Simeoli C, Di Paola N, Colao A
Pituitary 2022 Oct;25(5):726-732. Epub 2022 Aug 29 doi: 10.1007/s11102-022-01262-8. PMID: 36036308Free PMC Article
Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Cushing's syndrome: Treatment and new therapeutic approaches.
Ferriere A, Tabarin A
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101381. Epub 2020 Jan 30 doi: 10.1016/j.beem.2020.101381. PMID: 32035797
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's Syndrome: Screening and Diagnosis.
Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

Prognosis

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
Cushing's disease.
Ferriere A, Tabarin A
Presse Med 2021 Dec;50(4):104091. Epub 2021 Oct 27 doi: 10.1016/j.lpm.2021.104091. PMID: 34718112
Cushing's Syndrome: Screening and Diagnosis.
Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717
Cushing's syndrome.
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339
Side effects of corticosteroid therapy.
Buchman AL
J Clin Gastroenterol 2001 Oct;33(4):289-94. doi: 10.1097/00004836-200110000-00006. PMID: 11588541

Clinical prediction guides

Cushing Syndrome: A Review.
Reincke M, Fleseriu M
JAMA 2023 Jul 11;330(2):170-181. doi: 10.1001/jama.2023.11305. PMID: 37432427
Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
Approach to the Patient: Diagnosis of Cushing Syndrome.
Savas M, Mehta S, Agrawal N, van Rossum EFC, Feelders RA
J Clin Endocrinol Metab 2022 Nov 23;107(11):3162-3174. doi: 10.1210/clinem/dgac492. PMID: 36036941Free PMC Article
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Cushing's Syndrome: Screening and Diagnosis.
Ceccato F, Boscaro M
High Blood Press Cardiovasc Prev 2016 Sep;23(3):209-15. Epub 2016 May 9 doi: 10.1007/s40292-016-0153-4. PMID: 27160717

Recent systematic reviews

Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis.
Mondin A, Barbot M, Voltan G, Tizianel I, Vedolin CK, Mazzeo P, Lazzara M, Boscaro M, Scaroni C, Ceccato F
J Endocrinol Invest 2023 Oct;46(10):1947-1959. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02099-z. PMID: 37079177Free PMC Article
Time to Diagnosis in Cushing's Syndrome: A Meta-Analysis Based on 5367 Patients.
Rubinstein G, Osswald A, Hoster E, Losa M, Elenkova A, Zacharieva S, Machado MC, Hanzu FA, Zopp S, Ritzel K, Riester A, Braun LT, Kreitschmann-Andermahr I, Storr HL, Bansal P, Barahona MJ, Cosaro E, Dogansen SC, Johnston PC, Santos de Oliveira R, Raftopoulos C, Scaroni C, Valassi E, van der Werff SJA, Schopohl J, Beuschlein F, Reincke M
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgz136. PMID: 31665382
Systematic review of surgical treatment of subclinical Cushing's syndrome.
Iacobone M, Citton M, Scarpa M, Viel G, Boscaro M, Nitti D
Br J Surg 2015 Mar;102(4):318-30. Epub 2015 Feb 2 doi: 10.1002/bjs.9742. PMID: 25640696
Silent corticotroph adenomas.
Cooper O
Pituitary 2015 Apr;18(2):225-31. doi: 10.1007/s11102-014-0624-3. PMID: 25534889Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...