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Childhood acute megakaryoblastic leukemia

MedGen UID:
79023
Concept ID:
C0279650
Neoplastic Process
Synonyms: Childhood Acute M7 Leukemia; Childhood Acute Megakaryoblastic Leukemia; childhood acute megakaryoblastic leukemia; Childhood Acute Megakaryocytic Leukemia; Childhood Acute Megakaryocytic Leukemia (M7); M7 Childhood Acute Megakaryocytic Leukemia; M7 Pediatric Acute Megakaryocytic Leukemia; Pediatric Acute M7 Leukemia; Pediatric Acute Megakaryoblastic Leukemia; Pediatric Acute Megakaryocytic Leukemia
 
Monarch Initiative: MONDO:0850267

Definition

An acute megakaryoblastic leukemia occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood acute megakaryoblastic leukemia

Professional guidelines

PubMed

Wiggers CRM, Govers AMAP, Lelieveld D, Egan DA, Zwaan CM, Sonneveld E, Coffer PJ, Bartels M
Pediatr Blood Cancer 2019 Aug;66(8):e27785. Epub 2019 May 1 doi: 10.1002/pbc.27785. PMID: 31044544

Recent clinical studies

Etiology

Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Savaşan S, Buck S, Raimondi SC, Becton DL, Weinstein H, Chang M, Ravindranath Y
Leuk Lymphoma 2006 Oct;47(10):2076-83. doi: 10.1080/10428190600773180. PMID: 17071479
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Diagnosis

Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Therapy

Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Kandi R, Gutti U, Saladi RG, Gutti RK
Hematol Oncol Stem Cell Ther 2015 Jun;8(2):95-7. Epub 2014 Dec 27 doi: 10.1016/j.hemonc.2014.11.008. PMID: 25571789
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Prognosis

Qi H, Mao Y, Cao Q, Sun X, Kuai W, Song J, Ma L, Hong Z, Hu J, Zhou G
Med Sci Monit 2020 Jun 13;26:e922662. doi: 10.12659/MSM.922662. PMID: 32532951Free PMC Article
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang TT, Creutzig U, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang DC, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt D, Rodriguez L, Van Roy N, Shen S, Taga T, Tomizawa D, Yeoh AE, Zimmermann M, Raimondi SC
Blood 2015 Sep 24;126(13):1575-84. Epub 2015 Jul 27 doi: 10.1182/blood-2015-02-629204. PMID: 26215111Free PMC Article
Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC
Blood 2001 Jun 15;97(12):3727-32. doi: 10.1182/blood.v97.12.3727. PMID: 11389009
Ota S, Sato T, Kakuda H, Hirano K, Okimoto Y, Mori T, Nakazawa S, Kojima S, Matsuyama T, Tsuruo T
Leuk Lymphoma 1995 Nov;19(5-6):431-6. doi: 10.3109/10428199509112201. PMID: 8590843

Clinical prediction guides

Miyauchi J, Sugita K, Okui M, Taguchi N, Clark SC, Shimizu K
J Cell Physiol 1991 Sep;148(3):404-13. doi: 10.1002/jcp.1041480311. PMID: 1655816
Shimizu H, Ui T, Sasaki K, Kawai S, Kaneko Y, Fujimoto T
Am J Pediatr Hematol Oncol 1990 Winter;12(4):477-9. doi: 10.1097/00043426-199024000-00013. PMID: 2285130

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