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Adult Subependymoma

MedGen UID:
79277
•Concept ID:
C0281328
•
Neoplastic Process
Synonyms: Adult Subependymal Astrocytoma; Adult Subependymal Astrocytomas; Astrocytoma, Adult Subependymal; Astrocytomas, Adult Subependymal; Subependymal Astrocytoma, Adult; Subependymal Astrocytomas, Adult

Definition

A subependymoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Subependymoma

Professional guidelines

PubMed

Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.
Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
Biology and management of ependymomas.
Wu J, Armstrong TS, Gilbert MR
Neuro Oncol 2016 Jul;18(7):902-13. Epub 2016 Mar 28 doi: 10.1093/neuonc/now016. PMID: 27022130Free PMC Article
Intraocular astrocytoma and its differential diagnosis.
Pusateri A, Margo CE
Arch Pathol Lab Med 2014 Sep;138(9):1250-4. doi: 10.5858/arpa.2013-0448-RS. PMID: 25171711

Recent clinical studies

Etiology

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Imaging characteristics of 4th ventricle subependymoma.
Haider AS, El Ahmadieh TY, Haider M, Hatanpaa KJ, Pinho MC, Mickey BE, Sawaya R, Fuller GN, Schomer DF, Gule-Monroe M
Neuroradiology 2022 Sep;64(9):1795-1800. Epub 2022 Apr 15 doi: 10.1007/s00234-022-02944-7. PMID: 35426054Free PMC Article
An update on the central nervous system manifestations of neurofibromatosis type 1.
Nix JS, Blakeley J, Rodriguez FJ
Acta Neuropathol 2020 Apr;139(4):625-641. Epub 2019 Apr 8 doi: 10.1007/s00401-019-02002-2. PMID: 30963251Free PMC Article
Characterization of gliomas: from morphology to molecules.
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
Biology and management of ependymomas.
Wu J, Armstrong TS, Gilbert MR
Neuro Oncol 2016 Jul;18(7):902-13. Epub 2016 Mar 28 doi: 10.1093/neuonc/now016. PMID: 27022130Free PMC Article

Diagnosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors.
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ
Neuro Oncol 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833Free PMC Article
Imaging characteristics of 4th ventricle subependymoma.
Haider AS, El Ahmadieh TY, Haider M, Hatanpaa KJ, Pinho MC, Mickey BE, Sawaya R, Fuller GN, Schomer DF, Gule-Monroe M
Neuroradiology 2022 Sep;64(9):1795-1800. Epub 2022 Apr 15 doi: 10.1007/s00234-022-02944-7. PMID: 35426054Free PMC Article
An update on the central nervous system manifestations of neurofibromatosis type 1.
Nix JS, Blakeley J, Rodriguez FJ
Acta Neuropathol 2020 Apr;139(4):625-641. Epub 2019 Apr 8 doi: 10.1007/s00401-019-02002-2. PMID: 30963251Free PMC Article
Rare glial tumors.
Soffietti R, Rudà R, Reardon D
Handb Clin Neurol 2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368

Therapy

Spinal subependymoma surgery: do no harm. Little may be more!
Soleiman HA, Ironside J, Kealey S, Demetriades AK
Neurosurg Rev 2020 Aug;43(4):1047-1053. Epub 2019 Jun 18 doi: 10.1007/s10143-019-01128-x. PMID: 31214945
Surgical management and long-term outcome of intracranial subependymoma.
Varma A, Giraldi D, Mills S, Brodbelt AR, Jenkinson MD
Acta Neurochir (Wien) 2018 Sep;160(9):1793-1799. Epub 2018 Jun 18 doi: 10.1007/s00701-018-3570-4. PMID: 29915887Free PMC Article
Recognizing intraventricular silicone.
Mayl JJ, Flores MA, Stelzer JW, Liu B, Messina SA, Murray JV
Emerg Radiol 2018 Apr;25(2):215-218. Epub 2018 Feb 3 doi: 10.1007/s10140-018-1582-2. PMID: 29397464
Recent Advances in the Classification and Treatment of Ependymomas.
Leeper H, Felicella MM, Walbert T
Curr Treat Options Oncol 2017 Aug 10;18(9):55. doi: 10.1007/s11864-017-0496-7. PMID: 28795287
Therapeutic targets in subependymoma.
Kong LY, Wei J, Haider AS, Liebelt BD, Ling X, Conrad CA, Fuller GN, Levine NB, Priebe W, Sawaya R, Heimberger AB
J Neuroimmunol 2014 Dec 15;277(1-2):168-75. Epub 2014 Oct 31 doi: 10.1016/j.jneuroim.2014.10.008. PMID: 25465288

Prognosis

Benign Glioma.
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.
Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors.
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ
Neuro Oncol 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833Free PMC Article
Characterization of gliomas: from morphology to molecules.
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
Rare glial tumors.
Soffietti R, Rudà R, Reardon D
Handb Clin Neurol 2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368

Clinical prediction guides

Intramedullary Subependymoma Of Lower Thoracic Cord.
Bashir HH, Aziz HF, Shamim MS
J Pak Med Assoc 2023 Sep;73(9):1919-1920. doi: 10.47391/JPMA.23-66. PMID: 37817716
EANO - EURACAN - SNO Guidelines on circumscribed astrocytic gliomas, glioneuronal, and neuronal tumors.
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ
Neuro Oncol 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833Free PMC Article
Characterization of gliomas: from morphology to molecules.
Ferris SP, Hofmann JW, Solomon DA, Perry A
Virchows Arch 2017 Aug;471(2):257-269. Epub 2017 Jul 4 doi: 10.1007/s00428-017-2181-4. PMID: 28674742
The Role of Molecular Diagnostics in the Management of Patients with Gliomas.
Wirsching HG, Weller M
Curr Treat Options Oncol 2016 Oct;17(10):51. doi: 10.1007/s11864-016-0430-4. PMID: 27501915
Therapeutic targets in subependymoma.
Kong LY, Wei J, Haider AS, Liebelt BD, Ling X, Conrad CA, Fuller GN, Levine NB, Priebe W, Sawaya R, Heimberger AB
J Neuroimmunol 2014 Dec 15;277(1-2):168-75. Epub 2014 Oct 31 doi: 10.1016/j.jneuroim.2014.10.008. PMID: 25465288

Recent systematic reviews

Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.
Farooqi S, Tebha SS, Qamar MA, Singh S, Alfawares Y, Ramanathan V, Haider AS, Ferini G, Sharma M, Umana GE, Aoun SG, Palmisciano P
World Neurosurg 2023 May;173:237-250.e8. Epub 2023 Feb 28 doi: 10.1016/j.wneu.2023.02.098. PMID: 36858296
Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review.
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Multi-parametric MR Imaging Biomarkers Associated to Clinical Outcomes in Gliomas: A Systematic Review.
Oltra-Sastre M, Fuster-Garcia E, Juan-Albarracin J, Sáez C, Perez-Girbes A, Sanz-Requena R, Revert-Ventura A, Mocholi A, Urchueguia J, Hervas A, Reynes G, Font-de-Mora J, Muñoz-Langa J, Botella C, Aparici F, Marti-Bonmati L, Garcia-Gomez JM
Curr Med Imaging Rev 2019;15(10):933-947. doi: 10.2174/1573405615666190109100503. PMID: 32008521

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