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Adverse Event Following Immunization

MedGen UID:
811073
•Concept ID:
C2721654
•
Pathologic Function

Definition

Any unfavorable or unintended symptom, sign, or disease including an abnormal laboratory finding) temporally associated with the previous administration of vaccine(s) that may or may not be considered related to the vaccine administration. Such events can be intervention related, dose related, route related, patient related, or caused by an interaction with other product(s) or procedure(s). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdverse Event Following Immunization

Professional guidelines

PubMed

Vaccination attitudes, beliefs and behaviours among primary health care workers in northern Croatia.
Tomljenovic M, Petrovic G, Antoljak N, Hansen L
Vaccine 2021 Jan 22;39(4):738-745. Epub 2020 Dec 30 doi: 10.1016/j.vaccine.2020.11.049. PMID: 33386176
Primary immunodeficiency disease: a retrospective study of 112 Chinese children in a single tertiary care center.
Wu J, Zhong W, Yin Y, Zhang H
BMC Pediatr 2019 Nov 4;19(1):410. doi: 10.1186/s12887-019-1729-7. PMID: 31684895Free PMC Article

Recent clinical studies

Etiology

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis.
Kouhpayeh H, Ansari H
Int Immunopharmacol 2022 Aug;109:108906. Epub 2022 May 30 doi: 10.1016/j.intimp.2022.108906. PMID: 35671640Free PMC Article
A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Arthritis and arthralgia as an adverse event following immunization: A systematic literature review.
Panozzo CA, Pourmalek F, Brauchli Pernus Y, Pileggi GS, Woerner A, Bonhoeffer J; Brighton Collaboration Aseptic Arthritis Working Group
Vaccine 2019 Jan 7;37(2):372-383. Epub 2018 Nov 28 doi: 10.1016/j.vaccine.2018.06.067. PMID: 30502066
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442
Adverse event following immunization surveillance systems for pregnant women and their infants: a systematic review.
Cassidy C, MacDonald NE, Steenbeek A, Top KA
Pharmacoepidemiol Drug Saf 2015 Apr;24(4):361-7. Epub 2015 Feb 12 doi: 10.1002/pds.3754. PMID: 25683692

Diagnosis

Adverse event following immunization or vaccination in children in Minas Gerais: 2015 to 2020.
Camargos SM, Oliveira MLS, Luvisaro BMO, Silva TPRD, Souza JFA, Vimieiro AM, Silva TMRD, Matozinhos FP
Rev Bras Epidemiol 2023;26:e230056. Epub 2023 Dec 11 doi: 10.1590/1980-549720230056. PMID: 38088715Free PMC Article
Surveillance on the adverse events following immunization with the pentavalent vaccine in Zhejiang, China.
Pan X, Lv H, Liang H, Wang Y, Shen L, Chen F, Chen Y, Hu Y
Hum Vaccin Immunother 2022 Dec 31;18(1):2021711. Epub 2022 Feb 2 doi: 10.1080/21645515.2021.2021711. PMID: 35108152Free PMC Article
Acute respiratory distress syndrome (ARDS) as an adverse event following immunization: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.
Serazin NA, Edem B, Williams SR, Ortiz JR, Kawade A, Das MK, Šubelj M, Edwards KM, Parida SK, Wartel TA, Munoz FM, Bastero P
Vaccine 2021 May 21;39(22):3028-3036. Epub 2021 Jan 28 doi: 10.1016/j.vaccine.2021.01.053. PMID: 33583673Free PMC Article
Immunization stress-related response - Redefining immunization anxiety-related reaction as an adverse event following immunization.
Gold MS, MacDonald NE, McMurtry CM, Balakrishnan MR, Heininger U, Menning L, Benes O, Pless R, Zuber PLF
Vaccine 2020 Mar 23;38(14):3015-3020. Epub 2020 Mar 2 doi: 10.1016/j.vaccine.2020.02.046. PMID: 32131975
A systematic review of adverse events following immunization during pregnancy and the newborn period.
Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB
Vaccine 2015 Nov 25;33(47):6453-65. Epub 2015 Sep 26 doi: 10.1016/j.vaccine.2015.08.043. PMID: 26413879Free PMC Article

Therapy

A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Subcutaneous nodules: an important adverse event following immunization.
Silcock R, Crawford NW, Perrett KP
Expert Rev Vaccines 2019 Apr;18(4):405-410. Epub 2019 Mar 11 doi: 10.1080/14760584.2019.1586540. PMID: 30808246
An approach to death as an adverse event following immunization.
Gold MS, Balakrishnan MR, Amarasinghe A, MacDonald NE
Vaccine 2016 Jan 4;34(2):212-217. Epub 2015 Nov 19 doi: 10.1016/j.vaccine.2015.11.018. PMID: 26608326
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442
Fever following immunization.
Tapiainen T, Heininger U
Expert Rev Vaccines 2005 Jun;4(3):419-27. doi: 10.1586/14760584.4.3.419. PMID: 16026253

Prognosis

Active Symptom-Based Surveillance of Adverse Events Following Immunization Among Individuals Vaccinated with ChAdOx1 nCoV-19 Coronavirus Vaccine in a Tertiary Hospital of Kerala.
Jose M, Rajmohan P, Thomas J, Krishna S, Antony B, Gopinathan UU, Iyyapan EM, Porinchu RM, Jose P, Raphael L, Kuttichira P
Curr Drug Saf 2022;17(4):327-334. doi: 10.2174/1574886317666220207120649. PMID: 35135453
Anaphylaxis After Immunization of Children and Adolescents in Germany.
Oberle D, Pavel J, Rieck T, Weichert S, Schroten H, Keller-Stanislawski B, Tenenbaum T
Pediatr Infect Dis J 2016 May;35(5):535-41. doi: 10.1097/INF.0000000000001073. PMID: 26835973
An approach to death as an adverse event following immunization.
Gold MS, Balakrishnan MR, Amarasinghe A, MacDonald NE
Vaccine 2016 Jan 4;34(2):212-217. Epub 2015 Nov 19 doi: 10.1016/j.vaccine.2015.11.018. PMID: 26608326
Consumer reporting of adverse events following immunization (AEFI): identifying predictors of reporting an AEFI.
Parrella A, Gold M, Braunack-Mayer A, Baghurst P, Marshall H
Hum Vaccin Immunother 2014;10(3):747-54. Epub 2014 Jan 9 doi: 10.4161/hv.27459. PMID: 24406315Free PMC Article
Adverse events following immunization with vaccines containing adjuvants.
Cerpa-Cruz S, Paredes-Casillas P, Landeros Navarro E, Bernard-Medina AG, Martínez-Bonilla G, Gutiérrez-Ureña S
Immunol Res 2013 Jul;56(2-3):299-303. doi: 10.1007/s12026-013-8400-4. PMID: 23576057

Clinical prediction guides

Barriers to healthcare workers reporting adverse events following immunization in Zhejiang province, China.
Lv H, Pan X, Wang Y, Liang H, Yu H
Hum Vaccin Immunother 2022 Nov 30;18(5):2083865. Epub 2022 Jul 12 doi: 10.1080/21645515.2022.2083865. PMID: 35820038Free PMC Article
A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Arthritis and arthralgia as an adverse event following immunization: A systematic literature review.
Panozzo CA, Pourmalek F, Brauchli Pernus Y, Pileggi GS, Woerner A, Bonhoeffer J; Brighton Collaboration Aseptic Arthritis Working Group
Vaccine 2019 Jan 7;37(2):372-383. Epub 2018 Nov 28 doi: 10.1016/j.vaccine.2018.06.067. PMID: 30502066
Analysis of adverse events following immunization caused by immunization errors.
Bisetto LH, Ciosak SI
Rev Bras Enferm 2017 Jan-Feb;70(1):87-95. doi: 10.1590/0034-7167-2016-0034. PMID: 28226046
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442

Recent systematic reviews

Adverse events following COVID-19 vaccination: A systematic review and meta-analysis.
Kouhpayeh H, Ansari H
Int Immunopharmacol 2022 Aug;109:108906. Epub 2022 May 30 doi: 10.1016/j.intimp.2022.108906. PMID: 35671640Free PMC Article
A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.
Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Risk of Recurrence of Adverse Events Following Immunization: A Systematic Review.
Zafack JG, De Serres G, Kiely M, Gariépy MC, Rouleau I, Top KA; Canadian Immunization Research Network
Pediatrics 2017 Sep;140(3) doi: 10.1542/peds.2016-3707. PMID: 28847985
Vasculitis as an adverse event following immunization - Systematic literature review.
Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, Brauchli Pernus Y, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J; Brighton Collaboration Vasculitis Working Group
Vaccine 2016 Dec 12;34(51):6641-6651. Epub 2015 Sep 21 doi: 10.1016/j.vaccine.2015.09.026. PMID: 26398442
Adverse event following immunization surveillance systems for pregnant women and their infants: a systematic review.
Cassidy C, MacDonald NE, Steenbeek A, Top KA
Pharmacoepidemiol Drug Saf 2015 Apr;24(4):361-7. Epub 2015 Feb 12 doi: 10.1002/pds.3754. PMID: 25683692

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