U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reactive airway disease

MedGen UID:
811342
•Concept ID:
C3714497
•
Disease or Syndrome
Synonyms: Hyperactive Airway Disease; hyperactive airway disease; Reactive Airway Disease; reactive airway disease; reactive airway disease (AQ)
SNOMED CT: Reactive airway disease (991000119106)
 
Monarch Initiative: MONDO:0100470

Definition

Coughing, wheezing, or shortness of breath that is triggered by allergens, infection, or other irritants. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive airway disease

Professional guidelines

PubMed

Burden and emergency department management of acute cough in children.
Anderson-James S, Marchant JM, Chang AB, Acworth JP, Phillips NT, Drescher BJ, Goyal V, O'Grady KF
J Paediatr Child Health 2019 Feb;55(2):181-187. Epub 2018 Aug 1 doi: 10.1111/jpc.14146. PMID: 30066972
Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing.
Kimpen JL
Respir Res 2002;3 Suppl 1(Suppl 1):S40-5. doi: 10.1186/rr183. PMID: 12119057Free PMC Article
Management of reactive airway disease.
Jaimovich D, Kecskes SA
Crit Care Clin 1992 Jan;8(1):147-62. PMID: 1732027

Recent clinical studies

Etiology

Bronchopulmonary dysplasia.
Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Clinical Outcomes for Young Children Diagnosed With Asthma Versus Reactive Airway Disease.
Frey SM, Goldstein NPN, Kwiatkowski V, Reinish A
Acad Pediatr 2022 Jan-Feb;22(1):37-46. Epub 2021 Jun 18 doi: 10.1016/j.acap.2021.06.009. PMID: 34153535
Obesity-related asthma in adults.
Bhatt NA, Lazarus A
Postgrad Med 2016 Aug;128(6):563-6. Epub 2016 Jul 7 doi: 10.1080/00325481.2016.1204211. PMID: 27336439
Helminths as governors of immune-mediated inflammation.
Elliott DE, Summers RW, Weinstock JV
Int J Parasitol 2007 Apr;37(5):457-64. Epub 2006 Dec 28 doi: 10.1016/j.ijpara.2006.12.009. PMID: 17313951
Enalapril-induced cough.
Gibson GR
Arch Intern Med 1989 Dec;149(12):2701-3. PMID: 2556977

Diagnosis

Bronchopulmonary dysplasia.
Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Methacrylate perspective in current dental practice.
Bishop S, Roberts H
J Esthet Restor Dent 2020 Oct;32(7):673-680. Epub 2020 Aug 3 doi: 10.1111/jerd.12633. PMID: 32744420
Respiratory Considerations Including Airway and Ventilation Issues in Critical Care Obstetric Patients.
Ende H, Varelmann D
Obstet Gynecol Clin North Am 2016 Dec;43(4):699-708. doi: 10.1016/j.ogc.2016.07.002. PMID: 27816155
Regadenoson.
Bengalorkar GM, Bhuvana K, Sarala N, Kumar TN
J Postgrad Med 2012 Apr-Jun;58(2):140-6. doi: 10.4103/0022-3859.97177. PMID: 22718059
Management of reactive airway disease.
Jaimovich D, Kecskes SA
Crit Care Clin 1992 Jan;8(1):147-62. PMID: 1732027

Therapy

Clinical Outcomes for Young Children Diagnosed With Asthma Versus Reactive Airway Disease.
Frey SM, Goldstein NPN, Kwiatkowski V, Reinish A
Acad Pediatr 2022 Jan-Feb;22(1):37-46. Epub 2021 Jun 18 doi: 10.1016/j.acap.2021.06.009. PMID: 34153535
Dysphonia associated with the use of inhaled corticosteroids.
Chmielewska M, Akst LM
Curr Opin Otolaryngol Head Neck Surg 2015 Jun;23(3):255-9. doi: 10.1097/MOO.0000000000000153. PMID: 25887975
Regadenoson.
Bengalorkar GM, Bhuvana K, Sarala N, Kumar TN
J Postgrad Med 2012 Apr-Jun;58(2):140-6. doi: 10.4103/0022-3859.97177. PMID: 22718059
Immunodeficiency syndromes and reactive airway disease.
Silk HJ
J Asthma 1994;31(4):231-41. doi: 10.3109/02770909409089471. PMID: 8040149
Enalapril-induced cough.
Gibson GR
Arch Intern Med 1989 Dec;149(12):2701-3. PMID: 2556977

Prognosis

Modified lung ultrasound score for bronchopulmonary dysplasia predicts late respiratory outcomes in preterm infants.
Shen J, Du Y, Sun Y, Huang X, Zhou J, Chen C
Pediatr Pulmonol 2023 Sep;58(9):2551-2558. Epub 2023 Jun 9 doi: 10.1002/ppul.26546. PMID: 37294069
Evaluation of children diagnosed with a lower respiratory tract infection due to Human metapneumovirus.
Kıymet E, Böncüoğlu E, Çağlar İ, Sorguç Y, Genel F, Ecevit ÇÖ, Soylu ÖB, Apa H, Çelik T, Devrim İ, Bayram N
Turk J Pediatr 2022;64(3):446-450. doi: 10.24953/turkjped.2020.399. PMID: 35899557
Surgical Techniques for Tonsillectomy and Perioperative Respiratory Complications in Children.
Baijal RG, Wyatt KE, Shittu T, Chen EY, Wei EZ, Tan CJ, Lee M, Mehta DK
Otolaryngol Head Neck Surg 2022 Feb;166(2):373-381. Epub 2021 Jun 1 doi: 10.1177/01945998211015176. PMID: 34058915
Mediastinal Lymphadenopathy in Children With Histoplasmosis.
Staszak JK, Zmijewski P, Arnold S, Bagga B, Williams RF
J Surg Res 2019 Dec;244:558-565. Epub 2019 Jul 25 doi: 10.1016/j.jss.2019.06.062. PMID: 31352234
Special features of asthma in children.
Cropp GJ
Chest 1985 Jan;87(1 Suppl):55S-62S. doi: 10.1378/chest.87.1.55s. PMID: 3880532Free PMC Article

Clinical prediction guides

Bacillus Calmette-Guérin vaccination as defense against SARS-CoV-2 (BADAS): a randomized controlled trial to protect healthcare workers in the USA by enhanced trained immune responses.
DiNardo AR, Arditi M, Kamat AM, Koster KJ, Carrero S, Nishiguchi T, Lebedev M, Benjamin AB, Avalos P, Lozano M, Moule MG, McCune B, Herron B, Ladki M, Sheikh D, Spears M, Herrejon IA, Dodge C, Kumar S, Hutchison RW, Ofili TU, Opperman LA, Bernard JA, Lerner SP, Udeani G, Neal G, Netea MG, Cirillo JD
Trials 2023 Oct 4;24(1):636. doi: 10.1186/s13063-023-07662-w. PMID: 37794431Free PMC Article
Modified lung ultrasound score for bronchopulmonary dysplasia predicts late respiratory outcomes in preterm infants.
Shen J, Du Y, Sun Y, Huang X, Zhou J, Chen C
Pediatr Pulmonol 2023 Sep;58(9):2551-2558. Epub 2023 Jun 9 doi: 10.1002/ppul.26546. PMID: 37294069
Clinical presentation of paradoxical vocal fold motion or laryngeal dyskinesia in infants.
So RJ, Jenks C, Yi J, Ryan MA, Tunkel DE, Walsh JM
Int J Pediatr Otorhinolaryngol 2022 Nov;162:111304. Epub 2022 Sep 2 doi: 10.1016/j.ijporl.2022.111304. PMID: 36084476
Association of transcutaneous CO(2) with respiratory support: a prospective double blind observational study in children with bronchiolitis and reactive airway disease.
Shaikh N, Tripathi S, Whelan A, Ford J, Kim M, Deshpande G
J Clin Monit Comput 2022 Jun;36(3):809-816. Epub 2021 Apr 29 doi: 10.1007/s10877-021-00712-1. PMID: 33928469Free PMC Article
Avoiding unnecessary bronchoscopy in children with suspected foreign body aspiration using computed tomography.
Gibbons AT, Casar Berazaluce AM, Hanke RE, McNinch NL, Person A, Mehlman T, Rubin M, Ponsky TA
J Pediatr Surg 2020 Jan;55(1):176-181. Epub 2019 Oct 25 doi: 10.1016/j.jpedsurg.2019.09.045. PMID: 31706607

Recent systematic reviews

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials.
Lei WT, Lin HH, Tsai MC, Hung HH, Cheng YJ, Liu SJ, Lin CY, Yeh TL
Drug Des Devel Ther 2018;12:3825-3845. Epub 2018 Nov 8 doi: 10.2147/DDDT.S183527. PMID: 30510399Free PMC Article
Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome.
Soll R, Ozek E
Cochrane Database Syst Rev 2009 Jan 21;(1):CD000141. doi: 10.1002/14651858.CD000141.pub2. PMID: 19160177
Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data.
Destefano F, Pfeifer D, Nohynek H
Bull World Health Organ 2008 May;86(5):373-80. doi: 10.2471/blt.07.048025. PMID: 18545740Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...