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Spontaneous Preterm Birth

MedGen UID:
820709
•Concept ID:
C3827961
•
Finding

Definition

Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneous Preterm Birth

Professional guidelines

PubMed

Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234.
Hoffman MK
Obstet Gynecol 2021 Dec 1;138(6):945-946. doi: 10.1097/AOG.0000000000004612. PMID: 34794160Free PMC Article
Drugs for the Treatment and Prevention of Preterm Labor.
Patel SS, Ludmir J
Clin Perinatol 2019 Jun;46(2):159-172. doi: 10.1016/j.clp.2019.02.001. PMID: 31010553
Tocolysis: Present and future treatment options.
Younger JD, Reitman E, Gallos G
Semin Perinatol 2017 Dec;41(8):493-504. doi: 10.1053/j.semperi.2017.08.008. PMID: 29191291Free PMC Article

Recent clinical studies

Etiology

Deprived neighborhoods and spontaneous preterm birth: A national cohort study.
Klumper J, Ravelli ACJ, Roos C, Abu-Hanna A, Oudijk MA
Eur J Obstet Gynecol Reprod Biol 2022 Jul;274:88-95. Epub 2022 May 20 doi: 10.1016/j.ejogrb.2022.05.012. PMID: 35623155
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.
Conde-Agudelo A, Romero R, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Erez O, Pacora P, Nicolaides KH
Am J Obstet Gynecol 2018 Jul;219(1):10-25. Epub 2018 Apr 7 doi: 10.1016/j.ajog.2018.03.028. PMID: 29630885Free PMC Article
Not transabdominal!
Khalifeh A, Berghella V
Am J Obstet Gynecol 2016 Dec;215(6):739-744.e1. doi: 10.1016/j.ajog.2016.07.019. PMID: 27889000
Transabdominal ultrasound is appropriate.
Stamilio D, Carlson LM
Am J Obstet Gynecol 2016 Dec;215(6):739-743.e1. doi: 10.1016/j.ajog.2016.07.020. PMID: 27888999

Diagnosis

Pregnancy complications and later life women's health.
McNestry C, Killeen SL, Crowley RK, McAuliffe FM
Acta Obstet Gynecol Scand 2023 May;102(5):523-531. Epub 2023 Feb 17 doi: 10.1111/aogs.14523. PMID: 36799269Free PMC Article
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Tarca AL, Pataki BÁ, Romero R, Sirota M, Guan Y, Kutum R, Gomez-Lopez N, Done B, Bhatti G, Yu T, Andreoletti G, Chaiworapongsa T; DREAM Preterm Birth Prediction Challenge Consortium, Hassan SS, Hsu CD, Aghaeepour N, Stolovitzky G, Csabai I, Costello JC
Cell Rep Med 2021 Jun 15;2(6):100323. doi: 10.1016/j.xcrm.2021.100323. PMID: 34195686Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Cervical cerclage.
Suhag A, Berghella V
Clin Obstet Gynecol 2014 Sep;57(3):557-67. doi: 10.1097/GRF.0000000000000044. PMID: 24979354

Therapy

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Progesterone and preterm birth.
Norman JE
Int J Gynaecol Obstet 2020 Jul;150(1):24-30. doi: 10.1002/ijgo.13187. PMID: 32524598Free PMC Article
Marijuana Use in Pregnancy and While Breastfeeding.
Metz TD, Borgelt LM
Obstet Gynecol 2018 Nov;132(5):1198-1210. doi: 10.1097/AOG.0000000000002878. PMID: 30234728Free PMC Article
Not transabdominal!
Khalifeh A, Berghella V
Am J Obstet Gynecol 2016 Dec;215(6):739-744.e1. doi: 10.1016/j.ajog.2016.07.019. PMID: 27889000

Prognosis

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth.
Tarca AL, Pataki BÁ, Romero R, Sirota M, Guan Y, Kutum R, Gomez-Lopez N, Done B, Bhatti G, Yu T, Andreoletti G, Chaiworapongsa T; DREAM Preterm Birth Prediction Challenge Consortium, Hassan SS, Hsu CD, Aghaeepour N, Stolovitzky G, Csabai I, Costello JC
Cell Rep Med 2021 Jun 15;2(6):100323. doi: 10.1016/j.xcrm.2021.100323. PMID: 34195686Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.
Conde-Agudelo A, Romero R, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Erez O, Pacora P, Nicolaides KH
Am J Obstet Gynecol 2018 Jul;219(1):10-25. Epub 2018 Apr 7 doi: 10.1016/j.ajog.2018.03.028. PMID: 29630885Free PMC Article
Epidemiology and causes of preterm birth.
Goldenberg RL, Culhane JF, Iams JD, Romero R
Lancet 2008 Jan 5;371(9606):75-84. doi: 10.1016/S0140-6736(08)60074-4. PMID: 18177778Free PMC Article

Clinical prediction guides

Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Predicting Spontaneous Preterm Birth.
Kennedy C, O’Dwyer V
Ir Med J 2019 Aug 1;112(7):964. PMID: 31553145
Prevention of spontaneous preterm birth.
Daskalakis G, Goya M, Pergialiotis V, Cabero L, Kyvernitakis I, Antsaklis A, Arabin B
Arch Gynecol Obstet 2019 May;299(5):1261-1273. Epub 2019 Feb 14 doi: 10.1007/s00404-019-05095-y. PMID: 30761417
Not transabdominal!
Khalifeh A, Berghella V
Am J Obstet Gynecol 2016 Dec;215(6):739-744.e1. doi: 10.1016/j.ajog.2016.07.019. PMID: 27889000
Transabdominal ultrasound is appropriate.
Stamilio D, Carlson LM
Am J Obstet Gynecol 2016 Dec;215(6):739-743.e1. doi: 10.1016/j.ajog.2016.07.020. PMID: 27888999

Recent systematic reviews

Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis.
Conde-Agudelo A, Romero R, Rehal A, Brizot ML, Serra V, Da Fonseca E, Cetingoz E, Syngelaki A, Perales A, Hassan SS, Nicolaides KH
Am J Obstet Gynecol 2023 Dec;229(6):599-616.e3. Epub 2023 May 15 doi: 10.1016/j.ajog.2023.05.010. PMID: 37196896Free PMC Article
Does vaginal progesterone prevent recurrent preterm birth in women with a singleton gestation and a history of spontaneous preterm birth? Evidence from a systematic review and meta-analysis.
Conde-Agudelo A, Romero R
Am J Obstet Gynecol 2022 Sep;227(3):440-461.e2. Epub 2022 Apr 20 doi: 10.1016/j.ajog.2022.04.023. PMID: 35460628Free PMC Article
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis.
Care A, Nevitt SJ, Medley N, Donegan S, Good L, Hampson L, Tudur Smith C, Alfirevic Z
BMJ 2022 Feb 15;376:e064547. doi: 10.1136/bmj-2021-064547. PMID: 35168930Free PMC Article
Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis.
Chmielewska B, Barratt I, Townsend R, Kalafat E, van der Meulen J, Gurol-Urganci I, O'Brien P, Morris E, Draycott T, Thangaratinam S, Le Doare K, Ladhani S, von Dadelszen P, Magee L, Khalil A
Lancet Glob Health 2021 Jun;9(6):e759-e772. Epub 2021 Mar 31 doi: 10.1016/S2214-109X(21)00079-6. PMID: 33811827Free PMC Article
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data.
Romero R, Conde-Agudelo A, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Nicolaides KH
Am J Obstet Gynecol 2018 Feb;218(2):161-180. Epub 2017 Nov 17 doi: 10.1016/j.ajog.2017.11.576. PMID: 29157866Free PMC Article

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