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Intrapartum fever

MedGen UID:
822262
•Concept ID:
C3829514
•
Sign or Symptom
Synonyms: Intrapartum Pyrexia; Maternal fever during labor; Maternal fever during labour
 
HPO: HP:0030245

Definition

The occurence of maternal fever during labor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntrapartum fever

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Innovating Evaluation and Treatment of Intrapartum Fevers: Where Do We Go from Here?
Wilkie GL, James K, Ona S, Easter SR, Chou J, Roberts D, Sahin ZO, Tuomala R, Diouf K, Riley L, Prabhu M
Am J Perinatol 2023 Feb;40(3):250-254. Epub 2021 Apr 20 doi: 10.1055/s-0041-1727279. PMID: 33878764

Recent clinical studies

Etiology

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Severity of intrapartum fever and neonatal outcomes.
Hensel D, Zhang F, Carter EB, Frolova AI, Odibo AO, Kelly JC, Cahill AG, Raghuraman N
Am J Obstet Gynecol 2022 Sep;227(3):513.e1-513.e8. Epub 2022 May 19 doi: 10.1016/j.ajog.2022.05.031. PMID: 35598690
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Diagnosis

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Pulse perfusion index for predicting intrapartum fever during epidural analgesia.
Sun C, Ren S, Chen C, Liu Q, Lu P, Xia L, Shao D, Xu J
J Clin Anesth 2022 Sep;80:110852. Epub 2022 Apr 27 doi: 10.1016/j.jclinane.2022.110852. PMID: 35489302
Time- and dose-dependent correlations between patient-controlled epidural analgesia and intrapartum maternal fever.
Zhao BS, Li B, Wang QN, Jia JX, Song XR
BMC Anesthesiol 2021 Jan 29;21(1):31. doi: 10.1186/s12871-021-01249-1. PMID: 33514322Free PMC Article

Therapy

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms.
Sultan P, David AL, Fernando R, Ackland GL
Anesth Analg 2016 May;122(5):1546-53. doi: 10.1213/ANE.0000000000001195. PMID: 27101499
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Prognosis

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management.
Patel S, Ciechanowicz S, Blumenfeld YJ, Sultan P
Am J Obstet Gynecol 2023 May;228(5S):S1283-S1304.e1. Epub 2023 Mar 14 doi: 10.1016/j.ajog.2022.06.026. PMID: 36925412
Risk factors of maternal intrapartum fever and the effect of fever duration on neonatal morbidity in different temperature.
Yin H, Hu R
J Obstet Gynaecol Res 2022 Oct;48(10):2522-2527. Epub 2022 Jul 12 doi: 10.1111/jog.15362. PMID: 35820774
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms.
Sultan P, David AL, Fernando R, Ackland GL
Anesth Analg 2016 May;122(5):1546-53. doi: 10.1213/ANE.0000000000001195. PMID: 27101499
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Clinical prediction guides

Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Nomogram for perinatal prediction of intrapartum fever: a retrospective case-control study.
Jiang Z, Hu X, Zeng H, Wang X, Tan C, Ni C, Dai L, Liu S
BMC Pregnancy Childbirth 2021 Jun 25;21(1):445. doi: 10.1186/s12884-021-03891-6. PMID: 34172031Free PMC Article
Time- and dose-dependent correlations between patient-controlled epidural analgesia and intrapartum maternal fever.
Zhao BS, Li B, Wang QN, Jia JX, Song XR
BMC Anesthesiol 2021 Jan 29;21(1):31. doi: 10.1186/s12871-021-01249-1. PMID: 33514322Free PMC Article
Epidural-Related Fever and Maternal and Neonatal Morbidity: A Systematic Review and Meta-Analysis.
Jansen S, Lopriore E, Naaktgeboren C, Sueters M, Limpens J, van Leeuwen E, Bekker V
Neonatology 2020;117(3):259-270. Epub 2020 Jan 28 doi: 10.1159/000504805. PMID: 31991422

Recent systematic reviews

Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis.
Cartledge A, Hind D, Bradburn M, Martyn-St James M, Davenport S, Tung WS, Yung H, Wong J, Wilson M
Br J Anaesth 2022 Oct;129(4):567-580. Epub 2022 Aug 5 doi: 10.1016/j.bja.2022.06.022. PMID: 35934529Free PMC Article
Clinical Risk Factors Associated With Late-Onset Invasive Group B Streptococcal Disease: Systematic Review and Meta-Analyses.
Karampatsas K, Davies H, Mynarek M, Andrews N, Heath PT, Le Doare K
Clin Infect Dis 2022 Sep 30;75(7):1255-1264. doi: 10.1093/cid/ciac206. PMID: 35275986Free PMC Article
Remifentanil patient-controlled versus epidural analgesia on intrapartum maternal fever: a systematic review and meta-analysis.
Lu G, Yao W, Chen X, Zhang S, Zhou M
BMC Pregnancy Childbirth 2020 Mar 12;20(1):151. doi: 10.1186/s12884-020-2800-y. PMID: 32164593Free PMC Article
Epidural-Related Fever and Maternal and Neonatal Morbidity: A Systematic Review and Meta-Analysis.
Jansen S, Lopriore E, Naaktgeboren C, Sueters M, Limpens J, van Leeuwen E, Bekker V
Neonatology 2020;117(3):259-270. Epub 2020 Jan 28 doi: 10.1159/000504805. PMID: 31991422
Prenatal, perinatal and neonatal risk factors for perinatal arterial ischaemic stroke: a systematic review and meta-analysis.
Li C, Miao JK, Xu Y, Hua YY, Ma Q, Zhou LL, Liu HJ, Chen QX
Eur J Neurol 2017 Aug;24(8):1006-1015. Epub 2017 Jun 24 doi: 10.1111/ene.13337. PMID: 28646492

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