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Clinical Chorioamnionitis

MedGen UID:
823826
•Concept ID:
C3831078
•
Disease or Syndrome

Definition

Inflammation of the fetal sac membranes, characterized by otherwise unexplained fever (at or above 38 degree C (100.4F)) with one or more of the following: uterine tenderness and/or irritability, leukocytosis, fetal tachycardia, maternal tachycardia, or malodorous vaginal discharge. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClinical Chorioamnionitis

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article

Recent clinical studies

Etiology

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.
Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S29-52. doi: 10.1016/j.ajog.2015.08.040. PMID: 26428501Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article

Diagnosis

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Erythromycin vs azithromycin for treatment of preterm prelabor rupture of membranes: a systematic review and meta-analysis.
Seaman RD, Kopkin RH, Turrentine MA
Am J Obstet Gynecol 2022 Jun;226(6):794-801.e1. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.262. PMID: 34973176
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Diagnosis and management of clinical chorioamnionitis.
Tita AT, Andrews WW
Clin Perinatol 2010 Jun;37(2):339-54. doi: 10.1016/j.clp.2010.02.003. PMID: 20569811Free PMC Article

Therapy

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article

Prognosis

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial.
Roman A, Zork N, Haeri S, Schoen CN, Saccone G, Colihan S, Zelig C, Gimovsky AC, Seligman NS, Zullo F, Berghella V
Am J Obstet Gynecol 2020 Dec;223(6):902.e1-902.e11. Epub 2020 Jun 25 doi: 10.1016/j.ajog.2020.06.047. PMID: 32592693
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.
Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S29-52. doi: 10.1016/j.ajog.2015.08.040. PMID: 26428501Free PMC Article

Clinical prediction guides

Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Association of clinical signs of chorioamnionitis with histological chorioamnionitis and neonatal outcomes.
Ajayi SO, Morris J, Aleem S, Pease ME, Wang A, Mowes A, Welles SL, Anday EK, Bhandari V
J Matern Fetal Neonatal Med 2022 Dec;35(26):10337-10347. Epub 2022 Oct 4 doi: 10.1080/14767058.2022.2128648. PMID: 36195455
Clinical chorioamnionitis criteria are not sufficient for predicting intra-amniotic infection.
Maki Y, Furukawa S, Nakayama T, Oohashi M, Shiiba N, Furuta K, Tokunaga S, Sameshima H
J Matern Fetal Neonatal Med 2022 Jan;35(1):52-57. Epub 2020 Jan 8 doi: 10.1080/14767058.2020.1711725. PMID: 31914822
Amnioinfusion for chorioamnionitis.
Hofmeyr GJ, Kiiza JA
Cochrane Database Syst Rev 2016 Aug 24;2016(8):CD011622. doi: 10.1002/14651858.CD011622.pub2. PMID: 27556818Free PMC Article

Recent systematic reviews

Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: a systematic review and network meta-analysis.
Lin LL, Hung JN, Shiu SI, Su YH, Chen WC, Tseng JJ
Am J Obstet Gynecol MFM 2023 Jul;5(7):100978. Epub 2023 Apr 23 doi: 10.1016/j.ajogmf.2023.100978. PMID: 37094635
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Erythromycin vs azithromycin for treatment of preterm prelabor rupture of membranes: a systematic review and meta-analysis.
Seaman RD, Kopkin RH, Turrentine MA
Am J Obstet Gynecol 2022 Jun;226(6):794-801.e1. Epub 2021 Dec 29 doi: 10.1016/j.ajog.2021.12.262. PMID: 34973176
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article

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