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Aquagenic urticaria

MedGen UID:
82663
•Concept ID:
C0263334
•
Disease or Syndrome
Synonyms: Aquagenic Urticaria; Aquagenic Urticarias; Urticaria, Aquagenic
SNOMED CT: Aquagenic urticaria (89870006)
 
HPO: HP:0410136
Monarch Initiative: MONDO:0008632
OMIM®: 191850

Definition

A form of physical urticaria, in which contact with water, regardless of its temperature and source, evokes pruritic follicular wheals on the skin. [from HPO]

Clinical features

From HPO
Urticaria
MedGen UID:
22587
•Concept ID:
C0042109
•
Disease or Syndrome
Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAquagenic urticaria

Professional guidelines

PubMed

A Systematic Review of Aquagenic Urticaria-Subgroups and Treatment Options.
Rujitharanawong C, Kulthanan K, Tuchinda P, Chularojanamontri L, Metz M, Maurer M
J Allergy Clin Immunol Pract 2022 Aug;10(8):2154-2162. Epub 2022 May 6 doi: 10.1016/j.jaip.2022.04.033. PMID: 35533998
Management of urticaria and angioedema in children: new trends.
Oranje AP
G Ital Dermatol Venereol 2010 Dec;145(6):771-4. PMID: 21139553
Chronic urticaria: aetiology, management and current and future treatment options.
Kozel MM, Sabroe RA
Drugs 2004;64(22):2515-36. doi: 10.2165/00003495-200464220-00003. PMID: 15516152

Recent clinical studies

Etiology

Evidence for histamine release in chronic inducible urticaria - A systematic review.
Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M
Front Immunol 2022;13:901851. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.901851. PMID: 35967442Free PMC Article
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Clinical and etiologic evaluation of the children with chronic urticaria.
Azkur D, Civelek E, Toyran M, Mısırlıoğlu ED, Erkoçoğlu M, Kaya A, Vezir E, Giniş T, Akan A, Kocabaş CN
Allergy Asthma Proc 2016 Nov;37(6):450-457. doi: 10.2500/aap.2016.37.4010. PMID: 27931300
Management of urticaria and angioedema in children: new trends.
Oranje AP
G Ital Dermatol Venereol 2010 Dec;145(6):771-4. PMID: 21139553
Physical allergies.
Horan RF, Sheffer AL, Briner WW Jr
Med Sci Sports Exerc 1992 Aug;24(8):845-8. PMID: 1406166

Diagnosis

Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I
Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):141-148. PMID: 32975301
How to Approach Chronic Inducible Urticaria.
Maurer M, Fluhr JW, Khan DA
J Allergy Clin Immunol Pract 2018 Jul-Aug;6(4):1119-1130. doi: 10.1016/j.jaip.2018.03.007. PMID: 30033913
Aquagenic Urticaria: A Perplexing Physical Phenomenon.
Wassef C, Laureano A, Schwartz RA
Acta Dermatovenerol Croat 2017 Oct;25(3):234-237. PMID: 29252177
Aquagenic urticaria.
Casale TB, Olsen JA, DelasAlas HC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):295-6. Epub 2013 Apr 6 doi: 10.1016/j.jaip.2013.02.003. PMID: 24565488
Aquagenic urticaria.
Panconesi E, Lotti T
Clin Dermatol 1987 Jul-Sep;5(3):49-51. doi: 10.1016/s0738-081x(87)80008-1. PMID: 3664423

Therapy

Water-related dermatoses.
Hamie L, Abou-Rahal J
Int J Dermatol 2019 May;58(5):515-529. Epub 2018 Dec 2 doi: 10.1111/ijd.14316. PMID: 30506676
Aquagenic urticaria.
Casale TB, Olsen JA, DelasAlas HC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):295-6. Epub 2013 Apr 6 doi: 10.1016/j.jaip.2013.02.003. PMID: 24565488
Physical urticaria.
Dice JP
Immunol Allergy Clin North Am 2004 May;24(2):225-46, vi. doi: 10.1016/j.iac.2004.01.005. PMID: 15120149
Aquagenic urticaria.
Parker RK, Crowe MJ, Guin JD
Cutis 1992 Oct;50(4):283-4. PMID: 1424795
Chronic urticaria.
Burrall BA, Halpern GM, Huntley AC
West J Med 1990 Mar;152(3):268-76. PMID: 1970697Free PMC Article

Prognosis

Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India.
Kumaran MS, Mahajan R, Goyal N, Parsad D
Indian J Dermatol Venereol Leprol 2020 Jan-Feb;86(1):50-54. doi: 10.4103/ijdvl.IJDVL_573_17. PMID: 30264742
Chronic urticaria: aetiology, management and current and future treatment options.
Kozel MM, Sabroe RA
Drugs 2004;64(22):2515-36. doi: 10.2165/00003495-200464220-00003. PMID: 15516152
Hot water epilepsy: a benign and unrecognized form.
Ioos C, Fohlen M, Villeneuve N, Badinand-Hubert N, Jalin C, Cheliout-Heraut F, Pinard JM
J Child Neurol 2000 Feb;15(2):125-8. doi: 10.1177/088307380001500211. PMID: 10695897

Clinical prediction guides

Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India.
Kumaran MS, Mahajan R, Goyal N, Parsad D
Indian J Dermatol Venereol Leprol 2020 Jan-Feb;86(1):50-54. doi: 10.4103/ijdvl.IJDVL_573_17. PMID: 30264742
Omalizumab in Chronic Urticaria: An Italian Survey.
Damiani G, Diani M, Conic RRZ, Colli L, Ferrucci S, Martina E, Offidani AM, Pigatto PDM
Int Arch Allergy Immunol 2019;178(1):45-49. Epub 2018 Nov 5 doi: 10.1159/000492532. PMID: 30396176
Skin diseases in indigenous population: retrospective epidemiological study at Xingu Indigenous Park (XIP) and review of the literature.
Wu JSA, Florian MC, Rodrigues DA, Tomimori J
Int J Dermatol 2017 Dec;56(12):1414-1420. Epub 2017 Aug 9 doi: 10.1111/ijd.13716. PMID: 28791692
Hot water epilepsy: a benign and unrecognized form.
Ioos C, Fohlen M, Villeneuve N, Badinand-Hubert N, Jalin C, Cheliout-Heraut F, Pinard JM
J Child Neurol 2000 Feb;15(2):125-8. doi: 10.1177/088307380001500211. PMID: 10695897

Recent systematic reviews

Evidence for histamine release in chronic inducible urticaria - A systematic review.
Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M
Front Immunol 2022;13:901851. Epub 2022 Jul 28 doi: 10.3389/fimmu.2022.901851. PMID: 35967442Free PMC Article
A Systematic Review of Aquagenic Urticaria-Subgroups and Treatment Options.
Rujitharanawong C, Kulthanan K, Tuchinda P, Chularojanamontri L, Metz M, Maurer M
J Allergy Clin Immunol Pract 2022 Aug;10(8):2154-2162. Epub 2022 May 6 doi: 10.1016/j.jaip.2022.04.033. PMID: 35533998
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.
Maurer M, Metz M, Brehler R, Hillen U, Jakob T, Mahler V, Pföhler C, Staubach P, Treudler R, Wedi B, Magerl M
J Allergy Clin Immunol 2018 Feb;141(2):638-649. Epub 2017 Jul 24 doi: 10.1016/j.jaci.2017.06.032. PMID: 28751232

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