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Acute-On-Chronic Liver Failure

MedGen UID:
827235
Concept ID:
C3850141
Disease or Syndrome
Synonyms: Acute On Chronic Liver Failure; Acute On Chronic Liver Failure (ACLF); Acute-On-Chronic Liver Failure (ACLF); Acute-On-Chronic Liver Failures; Acute-On-Chronic Liver Failures (ACLF); Failure, Acute-On-Chronic Liver; Failure, Acute-On-Chronic Liver (ACLF); Failures, Acute-On-Chronic Liver; Failures, Acute-On-Chronic Liver (ACLF); Liver Failure, Acute On Chronic; Liver Failure, Acute-On-Chronic; Liver Failure, Acute-On-Chronic (ACLF); Liver Failures, Acute-On-Chronic; Liver Failures, Acute-On-Chronic (ACLF)

Definition

Sudden liver failure in the presence of underlying compensated chronic LIVER DISEASE (e.g., LIVER CIRRHOSIS; HEPATITIS; and liver injury and failure) due to a precipitating acute hepatic insult. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute-On-Chronic Liver Failure

Professional guidelines

PubMed

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):461-491. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.04.021. PMID: 37364789
Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS
Am J Gastroenterol 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. PMID: 35006099
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article

Recent clinical studies

Etiology

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):461-491. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.04.021. PMID: 37364789
Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B
Nat Rev Dis Primers 2016 Jun 9;2:16041. doi: 10.1038/nrdp.2016.41. PMID: 27277335
Sarin SK, Choudhury A
Nat Rev Gastroenterol Hepatol 2016 Mar;13(3):131-49. Epub 2016 Feb 3 doi: 10.1038/nrgastro.2015.219. PMID: 26837712
Asrani SK, Simonetto DA, Kamath PS
Clin Gastroenterol Hepatol 2015 Nov;13(12):2128-39. Epub 2015 Jul 15 doi: 10.1016/j.cgh.2015.07.008. PMID: 26188138Free PMC Article
Asrani SK, O'Leary JG
Clin Liver Dis 2014 Aug;18(3):561-74. doi: 10.1016/j.cld.2014.05.004. PMID: 25017076Free PMC Article

Diagnosis

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):461-491. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.04.021. PMID: 37364789
Ngu NLY, Flanagan E, Bell S, Le ST
World J Gastroenterol 2023 Jan 14;29(2):232-240. doi: 10.3748/wjg.v29.i2.232. PMID: 36687118Free PMC Article
Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M
J Hepatol 2021 Jul;75 Suppl 1(Suppl 1):S49-S66. doi: 10.1016/j.jhep.2021.01.002. PMID: 34039492Free PMC Article
Stravitz RT, Lee WM
Lancet 2019 Sep 7;394(10201):869-881. doi: 10.1016/S0140-6736(19)31894-X. PMID: 31498101Free PMC Article
Hernaez R, Solà E, Moreau R, Ginès P
Gut 2017 Mar;66(3):541-553. Epub 2017 Jan 4 doi: 10.1136/gutjnl-2016-312670. PMID: 28053053Free PMC Article

Therapy

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Aug;79(2):461-491. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.04.021. PMID: 37364789
Ngu NLY, Flanagan E, Bell S, Le ST
World J Gastroenterol 2023 Jan 14;29(2):232-240. doi: 10.3748/wjg.v29.i2.232. PMID: 36687118Free PMC Article
Saliba F, Bañares R, Larsen FS, Wilmer A, Parés A, Mitzner S, Stange J, Fuhrmann V, Gilg S, Hassanein T, Samuel D, Torner J, Jaber S
Intensive Care Med 2022 Oct;48(10):1352-1367. Epub 2022 Sep 6 doi: 10.1007/s00134-022-06802-1. PMID: 36066598
Arroyo V, Moreau R, Jalan R
N Engl J Med 2020 May 28;382(22):2137-2145. doi: 10.1056/NEJMra1914900. PMID: 32459924
Stravitz RT, Lee WM
Lancet 2019 Sep 7;394(10201):869-881. doi: 10.1016/S0140-6736(19)31894-X. PMID: 31498101Free PMC Article

Prognosis

Ngu NLY, Flanagan E, Bell S, Le ST
World J Gastroenterol 2023 Jan 14;29(2):232-240. doi: 10.3748/wjg.v29.i2.232. PMID: 36687118Free PMC Article
Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS
Am J Gastroenterol 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. PMID: 35006099
Hernaez R, Solà E, Moreau R, Ginès P
Gut 2017 Mar;66(3):541-553. Epub 2017 Jan 4 doi: 10.1136/gutjnl-2016-312670. PMID: 28053053Free PMC Article
Arroyo V, Moreau R, Kamath PS, Jalan R, Ginès P, Nevens F, Fernández J, To U, García-Tsao G, Schnabl B
Nat Rev Dis Primers 2016 Jun 9;2:16041. doi: 10.1038/nrdp.2016.41. PMID: 27277335
Sarin SK, Choudhury A
Nat Rev Gastroenterol Hepatol 2016 Mar;13(3):131-49. Epub 2016 Feb 3 doi: 10.1038/nrgastro.2015.219. PMID: 26837712

Clinical prediction guides

Luo J, Li J, Li P, Liang X, Hassan HM, Moreau R, Li J
Crit Care 2023 Jul 1;27(1):259. doi: 10.1186/s13054-023-04540-4. PMID: 37393351Free PMC Article
Br VK, Sarin SK
Clin Mol Hepatol 2023 Jul;29(3):670-689. Epub 2023 Mar 20 doi: 10.3350/cmh.2022.0103. PMID: 36938601Free PMC Article
Hernaez R, Solà E, Moreau R, Ginès P
Gut 2017 Mar;66(3):541-553. Epub 2017 Jan 4 doi: 10.1136/gutjnl-2016-312670. PMID: 28053053Free PMC Article
Sarin SK, Choudhury A
Nat Rev Gastroenterol Hepatol 2016 Mar;13(3):131-49. Epub 2016 Feb 3 doi: 10.1038/nrgastro.2015.219. PMID: 26837712
Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL–CLIF Consortium
Gastroenterology 2013 Jun;144(7):1426-37, 1437.e1-9. Epub 2013 Mar 6 doi: 10.1053/j.gastro.2013.02.042. PMID: 23474284

Recent systematic reviews

Beran A, Mohamed MFH, Shaear M, Nayfeh T, Mhanna M, Srour O, Nawras M, Mentrose JA, Assaly R, Kubal CA, Ghabril MS, Hernaez R, Patidar KR
Liver Transpl 2024 Feb 1;30(2):127-141. Epub 2023 Aug 3 doi: 10.1097/LVT.0000000000000231. PMID: 37530812
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
Tandon R, Froghi S
J Gastroenterol Hepatol 2021 May;36(5):1164-1179. Epub 2020 Oct 3 doi: 10.1111/jgh.15255. PMID: 32918840
Tan EX, Wang MX, Pang J, Lee GH
World J Gastroenterol 2020 Jan 14;26(2):219-245. doi: 10.3748/wjg.v26.i2.219. PMID: 31988586Free PMC Article
Peng Y, Qi X, Guo X
Medicine (Baltimore) 2016 Feb;95(8):e2877. doi: 10.1097/MD.0000000000002877. PMID: 26937922Free PMC Article

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