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Metabolic Side Effects of Drugs and Substances

MedGen UID:
827251
Concept ID:
C3850157
Pathologic Function

Definition

Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic Side Effects of Drugs and Substances

Professional guidelines

PubMed

Coughlin M, Goldie CL, Tranmer J, Khalid-Khan S, Tregunno D
Can J Psychiatry 2018 Apr;63(4):240-249. Epub 2018 Mar 11 doi: 10.1177/0706743717751693. PMID: 29528720Free PMC Article

Recent clinical studies

Etiology

Devonshire AL, Kumar R
Allergy Asthma Proc 2019 Nov 1;40(6):389-392. doi: 10.2500/aap.2019.40.4254. PMID: 31690377
Moreno-García E, Chumbita M, Puerta-Alcalde P, Cardozo C, García-Vidal C
Rev Esp Quimioter 2019 Sep;32 Suppl 2(Suppl 2):59-62. PMID: 31475813Free PMC Article
Vulsteke JB, Deeren D
Transpl Infect Dis 2019 Apr;21(2):e13039. Epub 2019 Jan 4 doi: 10.1111/tid.13039. PMID: 30548761
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540
Maggiolo F
Expert Opin Pharmacother 2007 Jun;8(8):1137-45. doi: 10.1517/14656566.8.8.1137. PMID: 17516877

Diagnosis

Schwartz IS, Kauffman CA
Semin Respir Crit Care Med 2020 Feb;41(1):31-41. Epub 2020 Jan 30 doi: 10.1055/s-0039-3400281. PMID: 32000282
Quindós G, Gil-Alonso S, Marcos-Arias C, Sevillano E, Mateo E, Jauregizar N, Eraso E
Med Oral Patol Oral Cir Bucal 2019 Mar 1;24(2):e172-e180. doi: 10.4317/medoral.22978. PMID: 30818309Free PMC Article
Aumeeruddy MZ, Mahomoodally MF
Cancer 2019 May 15;125(10):1600-1611. Epub 2019 Feb 27 doi: 10.1002/cncr.32022. PMID: 30811596
Vulsteke JB, Deeren D
Transpl Infect Dis 2019 Apr;21(2):e13039. Epub 2019 Jan 4 doi: 10.1111/tid.13039. PMID: 30548761
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540

Therapy

Maertens JA, Girmenia C, Brüggemann RJ, Duarte RF, Kibbler CC, Ljungman P, Racil Z, Ribaud P, Slavin MA, Cornely OA, Peter Donnelly J, Cordonnier C; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and the European LeukemiaNet (ELN)
J Antimicrob Chemother 2018 Dec 1;73(12):3221-3230. doi: 10.1093/jac/dky286. PMID: 30085172
Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Löhnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA
Ann Hematol 2018 Feb;97(2):197-207. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3196-2. PMID: 29218389Free PMC Article
Mahatme MS, Dakhale GN, Tadke K, Hiware SK, Dudhgaonkar SD, Wankhede S
Indian J Pharmacol 2016 Nov-Dec;48(6):649-653. doi: 10.4103/0253-7613.194854. PMID: 28066101Free PMC Article
Lipworth BJ
Lancet 1999 Jan 2;353(9146):57-62. doi: 10.1016/S0140-6736(98)09019-9. PMID: 10023966
Markham A, Faulds D
Drugs 1998 Aug;56(2):251-6; discussion 257. doi: 10.2165/00003495-199856020-00010. PMID: 9711449

Prognosis

Sato H, Kobayashi T, Fujita N, Yamashita T, Kitadate A, Yoshioka T, Nara M, Kameoka Y, Miura M, Takahashi N
Cancer Chemother Pharmacol 2022 Sep;90(3):279-284. Epub 2022 Aug 13 doi: 10.1007/s00280-022-04460-0. PMID: 35962819
Vulsteke JB, Deeren D
Transpl Infect Dis 2019 Apr;21(2):e13039. Epub 2019 Jan 4 doi: 10.1111/tid.13039. PMID: 30548761
Mahatme MS, Dakhale GN, Tadke K, Hiware SK, Dudhgaonkar SD, Wankhede S
Indian J Pharmacol 2016 Nov-Dec;48(6):649-653. doi: 10.4103/0253-7613.194854. PMID: 28066101Free PMC Article
Butt MS, Pasha I, Sultan MT, Randhawa MA, Saeed F, Ahmed W
Crit Rev Food Sci Nutr 2013;53(9):875-86. doi: 10.1080/10408398.2011.571799. PMID: 23768180
Manalai P, Woo JM, Postolache TT
Expert Opin Drug Saf 2009 May;8(3):273-82. doi: 10.1517/14740330902932688. PMID: 19505261

Clinical prediction guides

Paljarvi T, Forton J, Luciano S, Herttua K, Fazel S
JAMA Netw Open 2022 May 2;5(5):e2213643. doi: 10.1001/jamanetworkopen.2022.13643. PMID: 35608857Free PMC Article
Williams KM, Cheng GS, Pusic I, Jagasia M, Burns L, Ho VT, Pidala J, Palmer J, Johnston L, Mayer S, Chien JW, Jacobsohn DA, Pavletic SZ, Martin PJ, Storer BE, Inamoto Y, Chai X, Flowers MED, Lee SJ
Biol Blood Marrow Transplant 2016 Apr;22(4):710-716. Epub 2015 Oct 22 doi: 10.1016/j.bbmt.2015.10.009. PMID: 26475726Free PMC Article
Twarog M, Thompson GR 3rd
Semin Respir Crit Care Med 2015 Oct;36(5):746-55. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562900. PMID: 26398540
Manalai P, Woo JM, Postolache TT
Expert Opin Drug Saf 2009 May;8(3):273-82. doi: 10.1517/14740330902932688. PMID: 19505261
Markham A, Faulds D
Drugs 1998 Aug;56(2):251-6; discussion 257. doi: 10.2165/00003495-199856020-00010. PMID: 9711449

Recent systematic reviews

Mayoral K, Lizano-Barrantes C, Zamora V, Pont A, Miret C, Barrufet C, Caballero-Rabasco MA, Praena-Crespo M, Bercedo A, Valdesoiro-Navarrete L, Guerra MT, Pardo Y, Martínez Zapata MJ, Garin O, Ferrer M; ARCA Group
Eur Respir Rev 2023 Dec 31;32(170) Epub 2023 Oct 18 doi: 10.1183/16000617.0124-2023. PMID: 37852659Free PMC Article
Smith E, Stogios N, Au E, Maksyutynska K, De R, Ji A, Erlang Sørensen M, St John L, Lin HY, Desarkar P, Lunsky Y, Remington G, Hahn M, Agarwal SM
Acta Psychiatr Scand 2022 Sep;146(3):201-214. Epub 2022 Aug 5 doi: 10.1111/acps.13484. PMID: 35894550
Gaida R, Truter I, Grobler C, Kotze T, Godman B
Expert Rev Anti Infect Ther 2016;14(4):377-88. doi: 10.1586/14787210.2016.1157469. PMID: 26900637
Rix I, Håkansson K, Larsen CG, Frendø M, von Buchwald C
Am J Rhinol Allergy 2015 May-Jun;29(3):193-201. doi: 10.2500/ajra.2015.29.4178. PMID: 25975250
Kenedi CA, Goforth HW
AIDS Behav 2011 Nov;15(8):1803-18. doi: 10.1007/s10461-011-9939-5. PMID: 21484283

Supplemental Content

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