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Acute transverse myelitis

MedGen UID:
82847
•Concept ID:
C0270627
•
Disease or Syndrome
Synonyms: Acute Transverse Myelitis; Myelitis, Acute Transverse; Transverse Myelitis, Acute
SNOMED CT: Acute transverse myelitis (47000000)
 
Monarch Initiative: MONDO:0015342
Orphanet: ORPHA139417

Definition

A rare inflammatory demyelinating disorder of the spinal cord that can be either idiopathic (IATM) or secondary to a known cause (SATM). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute transverse myelitis
Follow this link to review classifications for Acute transverse myelitis in Orphanet.

Professional guidelines

PubMed

Differential diagnosis in acute inflammatory myelitis.
Marrodan M, Hernandez MA, Köhler AA, Correale J
Mult Scler Relat Disord 2020 Nov;46:102481. Epub 2020 Sep 2 doi: 10.1016/j.msard.2020.102481. PMID: 32905999
The Emergent Evaluation and Treatment of Neck and Back Pain.
Corwell BN, Davis NL
Emerg Med Clin North Am 2020 Feb;38(1):167-191. doi: 10.1016/j.emc.2019.09.007. PMID: 31757249
Proposed diagnostic criteria and nosology of acute transverse myelitis.
Transverse Myelitis Consortium Working Group
Neurology 2002 Aug 27;59(4):499-505. doi: 10.1212/wnl.59.4.499. PMID: 12236201

Recent clinical studies

Etiology

COVID-19 infection and stroke risk.
Sadeghmousavi S, Rezaei N
Rev Neurosci 2021 Apr 27;32(3):341-349. Epub 2020 Dec 24 doi: 10.1515/revneuro-2020-0066. PMID: 33580645
Frequency and etiology of acute transverse myelitis in Southern Finland.
Smith E, Jaakonmäki N, Nylund M, Kupila L, Matilainen M, Airas L
Mult Scler Relat Disord 2020 Nov;46:102562. Epub 2020 Oct 7 doi: 10.1016/j.msard.2020.102562. PMID: 33059215
Acute infectious myelopathies.
Isada CM, Miller R
Curr Opin Infect Dis 2020 Jun;33(3):251-258. doi: 10.1097/QCO.0000000000000650. PMID: 32332224
Pediatric transverse myelitis.
Absoud M, Greenberg BM, Lim M, Lotze T, Thomas T, Deiva K
Neurology 2016 Aug 30;87(9 Suppl 2):S46-52. doi: 10.1212/WNL.0000000000002820. PMID: 27572861
Proposed diagnostic criteria and nosology of acute transverse myelitis.
Transverse Myelitis Consortium Working Group
Neurology 2002 Aug 27;59(4):499-505. doi: 10.1212/wnl.59.4.499. PMID: 12236201

Diagnosis

Pediatric Spinal Cord Diseases.
Lu VM, Niazi TN
Pediatr Rev 2021 Sep;42(9):486-499. doi: 10.1542/pir.2020-000661. PMID: 34470868
Acute infectious myelopathies.
Isada CM, Miller R
Curr Opin Infect Dis 2020 Jun;33(3):251-258. doi: 10.1097/QCO.0000000000000650. PMID: 32332224
Infectious myelitis.
Lebrun Frenay C
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):464-468. Epub 2019 Jul 30 doi: 10.1016/j.neurol.2019.07.001. PMID: 31375285
Acute transverse myelitis: demyelinating, inflammatory, and infectious myelopathies.
West TW, Hess C, Cree BA
Semin Neurol 2012 Apr;32(2):97-113. Epub 2012 Sep 8 doi: 10.1055/s-0032-1322586. PMID: 22961185
Proposed diagnostic criteria and nosology of acute transverse myelitis.
Transverse Myelitis Consortium Working Group
Neurology 2002 Aug 27;59(4):499-505. doi: 10.1212/wnl.59.4.499. PMID: 12236201

Therapy

Spectrum of neurological complications following COVID-19 vaccination.
Garg RK, Paliwal VK
Neurol Sci 2022 Jan;43(1):3-40. Epub 2021 Oct 31 doi: 10.1007/s10072-021-05662-9. PMID: 34719776Free PMC Article
Acute Transverse Myelitis after COVID-19 Vaccination.
Hsiao YT, Tsai MJ, Chen YH, Hsu CF
Medicina (Kaunas) 2021 Sep 25;57(10) doi: 10.3390/medicina57101010. PMID: 34684047Free PMC Article
Pediatric acute demyelinating syndromes: identification and management in the emergency department.
Halfman C
Pediatr Emerg Med Pract 2021 Mar;18(3):1-16. Epub 2021 Mar 2 PMID: 33617213
Myelitis in systemic lupus erythematosus.
Li XY, Xiao HB, Pai P
J Clin Neurosci 2017 Oct;44:18-22. Epub 2017 Jul 8 doi: 10.1016/j.jocn.2017.06.003. PMID: 28694045
Neuroschistosomiasis.
Ross AG, McManus DP, Farrar J, Hunstman RJ, Gray DJ, Li YS
J Neurol 2012 Jan;259(1):22-32. Epub 2011 Jun 15 doi: 10.1007/s00415-011-6133-7. PMID: 21674195

Prognosis

Pediatric Spinal Cord Diseases.
Lu VM, Niazi TN
Pediatr Rev 2021 Sep;42(9):486-499. doi: 10.1542/pir.2020-000661. PMID: 34470868
Pediatric transverse myelitis.
Absoud M, Greenberg BM, Lim M, Lotze T, Thomas T, Deiva K
Neurology 2016 Aug 30;87(9 Suppl 2):S46-52. doi: 10.1212/WNL.0000000000002820. PMID: 27572861
Pediatric acute transverse myelitis overview and differential diagnosis.
Wolf VL, Lupo PJ, Lotze TE
J Child Neurol 2012 Nov;27(11):1426-36. Epub 2012 Aug 21 doi: 10.1177/0883073812452916. PMID: 22914370
Neuroschistosomiasis.
Ross AG, McManus DP, Farrar J, Hunstman RJ, Gray DJ, Li YS
J Neurol 2012 Jan;259(1):22-32. Epub 2011 Jun 15 doi: 10.1007/s00415-011-6133-7. PMID: 21674195
Transverse myelitis.
Borchers AT, Gershwin ME
Autoimmun Rev 2012 Jan;11(3):231-48. Epub 2011 May 18 doi: 10.1016/j.autrev.2011.05.018. PMID: 21621005

Clinical prediction guides

Current perspectives on the diagnosis and management of acute transverse myelitis.
Tisavipat N, Flanagan EP
Expert Rev Neurother 2023 Apr;23(4):389-411. Epub 2023 Apr 7 doi: 10.1080/14737175.2023.2195095. PMID: 37026545
Acute Transverse Myelitis after COVID-19 Vaccination.
Hsiao YT, Tsai MJ, Chen YH, Hsu CF
Medicina (Kaunas) 2021 Sep 25;57(10) doi: 10.3390/medicina57101010. PMID: 34684047Free PMC Article
Prognostic Parameters of Acute Transverse Myelitis in Children.
Ganelin-Cohen E, Konen O, Nevo Y, Cohen R, Halevy A, Shuper A, Aharoni S
J Child Neurol 2020 Dec;35(14):999-1003. Epub 2020 Aug 18 doi: 10.1177/0883073820947512. PMID: 32808576
Pediatric transverse myelitis.
Absoud M, Greenberg BM, Lim M, Lotze T, Thomas T, Deiva K
Neurology 2016 Aug 30;87(9 Suppl 2):S46-52. doi: 10.1212/WNL.0000000000002820. PMID: 27572861
Acute transverse myelitis and antiphospholipid antibodies in lupus. No evidence for anticoagulation.
Katsiari CG, Giavri I, Mitsikostas DD, Yiannopoulou KG, Sfikakis PP
Eur J Neurol 2011 Apr;18(4):556-63. Epub 2010 Sep 14 doi: 10.1111/j.1468-1331.2010.03208.x. PMID: 20840379

Recent systematic reviews

Covid-19 vaccines and neurological complications: a systematic review.
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Clinical characteristics, radiological features and prognostic factors of transverse myelitis following COVID-19 vaccination: A systematic review.
Ostovan VR, Sahraian MA, Karazhian N, Rostamihosseinkhani M, Salimi M, Marbooti H
Mult Scler Relat Disord 2022 Oct;66:104032. Epub 2022 Jul 6 doi: 10.1016/j.msard.2022.104032. PMID: 35858499Free PMC Article
Transverse myelitis in systemic lupus erythematosus: A case report and systematic literature review.
Wen X, Xu D, Yuan S, Zhang J
Autoimmun Rev 2022 Jun;21(6):103103. Epub 2022 Apr 20 doi: 10.1016/j.autrev.2022.103103. PMID: 35452852
Systematic review of cases of acute myelitis in individuals with COVID-19.
Schulte EC, Hauer L, Kunz AB, Sellner J
Eur J Neurol 2021 Oct;28(10):3230-3244. Epub 2021 Jul 12 doi: 10.1111/ene.14952. PMID: 34060708Free PMC Article
A systematic review of validated methods for identifying transverse myelitis using administrative or claims data.
Williams SE, Carnahan R, Krishnaswami S, McPheeters ML
Vaccine 2013 Dec 30;31 Suppl 10:K83-7. doi: 10.1016/j.vaccine.2013.03.074. PMID: 24331078

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