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Recurrent Childhood Rhabdomyosarcoma

MedGen UID:
82953
•Concept ID:
C0278649
•
Neoplastic Process
Synonyms: Recurrent Pediatric Rhabdomyosarcoma; Relapsed Childhood Rhabdomyosarcoma; Relapsed Pediatric Rhabdomyosarcoma

Definition

The reemergence of childhood rhabdomyosarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Rhabdomyosarcoma

Professional guidelines

PubMed

Paediatric genitourinary cancers and late effects of treatment.
Sadak KT, Ritchey ML, Dome JS
Nat Rev Urol 2013 Jan;10(1):15-25. Epub 2012 Nov 27 doi: 10.1038/nrurol.2012.218. PMID: 23183945
Childhood rhabdomyosarcoma: new insight on biology and treatment.
Huh WW, Skapek SX
Curr Oncol Rep 2010 Nov;12(6):402-10. doi: 10.1007/s11912-010-0130-3. PMID: 20820958
Problems and controversies in the management of childhood sarcomas.
Womer RB
Br Med Bull 1996 Oct;52(4):826-43. doi: 10.1093/oxfordjournals.bmb.a011586. PMID: 9039735

Recent clinical studies

Etiology

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Diagnosis

Cranial Irradiation for Childhood Cancers and Adult Risk of Meningioma.
Garcia CM, Ganga A, Weil RJ, Toms SA
Pediatr Neurosurg 2022;57(6):396-406. Epub 2022 Oct 17 doi: 10.1159/000527565. PMID: 36252549
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Rhabdomyosarcoma of the head and neck: 24 cases and literature review.
Moretti G, Guimarães R, Oliveira KM, Sanjar F, Voegels RL
Braz J Otorhinolaryngol 2010 Jul-Aug;76(4):533-7. doi: 10.1590/S1808-86942010000400020. PMID: 20835543Free PMC Article
Pediatric vulvovaginitis.
Altchek A
J Reprod Med 1984 Jun;29(6):359-75. PMID: 6747969

Therapy

Cranial Irradiation for Childhood Cancers and Adult Risk of Meningioma.
Garcia CM, Ganga A, Weil RJ, Toms SA
Pediatr Neurosurg 2022;57(6):396-406. Epub 2022 Oct 17 doi: 10.1159/000527565. PMID: 36252549
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Outcome and Patterns of Relapse in Childhood Parameningeal Rhabdomyosarcoma Treated With Proton Beam Therapy.
Doyen J, Jazmati D, Geismar D, Frisch S, Schleithoff SS, Vermeren X, Scheer M, Blase C, Tippelt S, Timmermann B
Int J Radiat Oncol Biol Phys 2019 Dec 1;105(5):1043-1054. Epub 2019 Aug 13 doi: 10.1016/j.ijrobp.2019.08.005. PMID: 31419513
Childhood rhabdomyosarcoma: new insight on biology and treatment.
Huh WW, Skapek SX
Curr Oncol Rep 2010 Nov;12(6):402-10. doi: 10.1007/s11912-010-0130-3. PMID: 20820958

Prognosis

Translational Implications for Radiosensitizing Strategies in Rhabdomyosarcoma.
Pomella S, Porrazzo A, Cassandri M, Camero S, Codenotti S, Milazzo L, Vulcano F, Barillari G, Cenci G, Marchese C, Fanzani A, Megiorni F, Rota R, Marampon F
Int J Mol Sci 2022 Oct 31;23(21) doi: 10.3390/ijms232113281. PMID: 36362070Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Rhabdomyosarcoma.
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Childhood rhabdomyosarcoma: new insight on biology and treatment.
Huh WW, Skapek SX
Curr Oncol Rep 2010 Nov;12(6):402-10. doi: 10.1007/s11912-010-0130-3. PMID: 20820958
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Clinical prediction guides

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1-2 trial.
Davis KL, Fox E, Merchant MS, Reid JM, Kudgus RA, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Lancet Oncol 2020 Apr;21(4):541-550. Epub 2020 Mar 17 doi: 10.1016/S1470-2045(20)30023-1. PMID: 32192573Free PMC Article
Outcome and Patterns of Relapse in Childhood Parameningeal Rhabdomyosarcoma Treated With Proton Beam Therapy.
Doyen J, Jazmati D, Geismar D, Frisch S, Schleithoff SS, Vermeren X, Scheer M, Blase C, Tippelt S, Timmermann B
Int J Radiat Oncol Biol Phys 2019 Dec 1;105(5):1043-1054. Epub 2019 Aug 13 doi: 10.1016/j.ijrobp.2019.08.005. PMID: 31419513
Childhood rhabdomyosarcoma: new insight on biology and treatment.
Huh WW, Skapek SX
Curr Oncol Rep 2010 Nov;12(6):402-10. doi: 10.1007/s11912-010-0130-3. PMID: 20820958

Recent systematic reviews

A systematic review of combined surgery and brachytherapy approaches for children and young people with relapsed and refractory rhabdomyosarcoma (Local-REFoRMS).
Ballantyne E, Evans C, Shepherd L, Fulbright H, Wakeling S, Phillips B, Morgan JE
Pediatr Blood Cancer 2024 Jun;71(6):e30952. Epub 2024 Apr 2 doi: 10.1002/pbc.30952. PMID: 38566349
A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS-SR project.
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594

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