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Advanced Malignant Mesothelioma

MedGen UID:
82976
•Concept ID:
C0278752
•
Neoplastic Process

Definition

A malignant mesothelioma that has spread beyond its original site of growth. [from NCI]

Professional guidelines

PubMed

Novel and Promising Systemic Treatment Approaches in Mesothelioma.
Dudnik E, Reinhorn D, Holtzman L
Curr Treat Options Oncol 2021 Aug 23;22(10):89. doi: 10.1007/s11864-021-00883-8. PMID: 34424409
Phase II trial of carboplatin in the management of malignant mesothelioma.
Raghavan D, Gianoutsos P, Bishop J, Lee J, Young I, Corte P, Bye P, McCaughan B
J Clin Oncol 1990 Jan;8(1):151-4. doi: 10.1200/JCO.1990.8.1.151. PMID: 2404086
Vindesine in the treatment of malignant mesothelioma: a phase II study.
Kelsen D, Gralla R, Cheng E, Martini N
Cancer Treat Rep 1983 Sep;67(9):821-2. PMID: 6883358

Recent clinical studies

Etiology

Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma.
Taghizadeh H, Zöchbauer-Müller S, Mader RM, Müllauer L, Klikovits T, Bachleitner-Hofmann T, Hoda MA, Prager GW
Thorac Cancer 2020 Jul;11(7):1979-1988. Epub 2020 May 21 doi: 10.1111/1759-7714.13491. PMID: 32438515Free PMC Article
Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: an open-label, single-arm, phase 2 study.
Calabrò L, Morra A, Fonsatti E, Cutaia O, Fazio C, Annesi D, Lenoci M, Amato G, Danielli R, Altomonte M, Giannarelli D, Di Giacomo AM, Maio M
Lancet Respir Med 2015 Apr;3(4):301-9. Epub 2015 Mar 26 doi: 10.1016/S2213-2600(15)00092-2. PMID: 25819643
Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial.
Calabrò L, Morra A, Fonsatti E, Cutaia O, Amato G, Giannarelli D, Di Giacomo AM, Danielli R, Altomonte M, Mutti L, Maio M
Lancet Oncol 2013 Oct;14(11):1104-1111. Epub 2013 Sep 11 doi: 10.1016/S1470-2045(13)70381-4. PMID: 24035405
Does video-assisted thoracoscopic decortication in advanced malignant mesothelioma improve prognosis?
Srivastava V, Dunning J, Au J
Interact Cardiovasc Thorac Surg 2009 Apr;8(4):454-6. Epub 2009 Jan 9 doi: 10.1510/icvts.2008.197160. PMID: 19136533
A phase II trial of interferon alpha-2a and carboplatin in patients with advanced malignant mesothelioma.
O'Reilly EM, Ilson DH, Saltz LB, Heelan R, Martin L, Kelsen DP
Cancer Invest 1999;17(3):195-200. doi: 10.3109/07357909909021421. PMID: 10099658

Diagnosis

Conversion surgery for locally advanced malignant pleural mesothelioma.
Terada Y, Isaka M, Murakami H, Kawata T, Konno H, Kojima H, Mizuno T, Ohde Y
Gen Thorac Cardiovasc Surg 2020 Dec;68(12):1547-1550. Epub 2020 Mar 12 doi: 10.1007/s11748-020-01329-y. PMID: 32166578
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Does video-assisted thoracoscopic decortication in advanced malignant mesothelioma improve prognosis?
Srivastava V, Dunning J, Au J
Interact Cardiovasc Thorac Surg 2009 Apr;8(4):454-6. Epub 2009 Jan 9 doi: 10.1510/icvts.2008.197160. PMID: 19136533

Therapy

Novel and Promising Systemic Treatment Approaches in Mesothelioma.
Dudnik E, Reinhorn D, Holtzman L
Curr Treat Options Oncol 2021 Aug 23;22(10):89. doi: 10.1007/s11864-021-00883-8. PMID: 34424409
Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma.
Taghizadeh H, Zöchbauer-Müller S, Mader RM, Müllauer L, Klikovits T, Bachleitner-Hofmann T, Hoda MA, Prager GW
Thorac Cancer 2020 Jul;11(7):1979-1988. Epub 2020 May 21 doi: 10.1111/1759-7714.13491. PMID: 32438515Free PMC Article
Conversion surgery for locally advanced malignant pleural mesothelioma.
Terada Y, Isaka M, Murakami H, Kawata T, Konno H, Kojima H, Mizuno T, Ohde Y
Gen Thorac Cardiovasc Surg 2020 Dec;68(12):1547-1550. Epub 2020 Mar 12 doi: 10.1007/s11748-020-01329-y. PMID: 32166578
Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial.
Calabrò L, Morra A, Fonsatti E, Cutaia O, Amato G, Giannarelli D, Di Giacomo AM, Danielli R, Altomonte M, Mutti L, Maio M
Lancet Oncol 2013 Oct;14(11):1104-1111. Epub 2013 Sep 11 doi: 10.1016/S1470-2045(13)70381-4. PMID: 24035405
Does video-assisted thoracoscopic decortication in advanced malignant mesothelioma improve prognosis?
Srivastava V, Dunning J, Au J
Interact Cardiovasc Thorac Surg 2009 Apr;8(4):454-6. Epub 2009 Jan 9 doi: 10.1510/icvts.2008.197160. PMID: 19136533

Prognosis

Improvements in Systemic Therapies for Advanced Malignant Mesothelioma.
Deiana C, Fabbri F, Tavolari S, Palloni A, Brandi G
Int J Mol Sci 2023 Jun 21;24(13) doi: 10.3390/ijms241310415. PMID: 37445594Free PMC Article
Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma.
Taghizadeh H, Zöchbauer-Müller S, Mader RM, Müllauer L, Klikovits T, Bachleitner-Hofmann T, Hoda MA, Prager GW
Thorac Cancer 2020 Jul;11(7):1979-1988. Epub 2020 May 21 doi: 10.1111/1759-7714.13491. PMID: 32438515Free PMC Article
Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial.
Calabrò L, Morra A, Fonsatti E, Cutaia O, Amato G, Giannarelli D, Di Giacomo AM, Danielli R, Altomonte M, Mutti L, Maio M
Lancet Oncol 2013 Oct;14(11):1104-1111. Epub 2013 Sep 11 doi: 10.1016/S1470-2045(13)70381-4. PMID: 24035405
Does video-assisted thoracoscopic decortication in advanced malignant mesothelioma improve prognosis?
Srivastava V, Dunning J, Au J
Interact Cardiovasc Thorac Surg 2009 Apr;8(4):454-6. Epub 2009 Jan 9 doi: 10.1510/icvts.2008.197160. PMID: 19136533
A phase II trial of interferon alpha-2a and carboplatin in patients with advanced malignant mesothelioma.
O'Reilly EM, Ilson DH, Saltz LB, Heelan R, Martin L, Kelsen DP
Cancer Invest 1999;17(3):195-200. doi: 10.3109/07357909909021421. PMID: 10099658

Clinical prediction guides

Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma.
Taghizadeh H, Zöchbauer-Müller S, Mader RM, Müllauer L, Klikovits T, Bachleitner-Hofmann T, Hoda MA, Prager GW
Thorac Cancer 2020 Jul;11(7):1979-1988. Epub 2020 May 21 doi: 10.1111/1759-7714.13491. PMID: 32438515Free PMC Article
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Does video-assisted thoracoscopic decortication in advanced malignant mesothelioma improve prognosis?
Srivastava V, Dunning J, Au J
Interact Cardiovasc Thorac Surg 2009 Apr;8(4):454-6. Epub 2009 Jan 9 doi: 10.1510/icvts.2008.197160. PMID: 19136533
Improved survival with VATS pleurectomy-decortication in advanced malignant mesothelioma.
Halstead JC, Lim E, Venkateswaran RM, Charman SC, Goddard M, Ritchie AJ
Eur J Surg Oncol 2005 Apr;31(3):314-20. doi: 10.1016/j.ejso.2004.08.014. PMID: 15780570
Randomized comparison of cyclophosphamide, imidazole carboxamide, and adriamycin versus cyclophosphamide and adriamycin in patients with advanced stage malignant mesothelioma: a Sarcoma Intergroup Study.
Samson MK, Wasser LP, Borden EC, Wanebo HJ, Creech RH, Phillips M, Baker LH
J Clin Oncol 1987 Jan;5(1):86-91. doi: 10.1200/JCO.1987.5.1.86. PMID: 3543239

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