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Crypt abscess

MedGen UID:
83075
•Concept ID:
C0333374
•
Pathologic Function
Synonym: Crypt abscesses
SNOMED CT: Crypt abscess (37771006)

Definition

Accumulation of polymorphonuclear neutrophils in the mucosal crypts of the colon. It occurs in ulcerative colitis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrypt abscess

Professional guidelines

PubMed

The role of mesalazine co-treatment in the prevention of recurrence in subjects with subclinical inflammatory bowel disease and perianal fistula who are scheduled for surgical intervention.
Akturk R, Serinsöz S
Ann Ital Chir 2022;93:183-187. PMID: 35311735
Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.
Hwang JB, Park MH, Kang YN, Kim SP, Suh SI, Kam S
J Korean Med Sci 2007 Apr;22(2):213-7. doi: 10.3346/jkms.2007.22.2.213. PMID: 17449926Free PMC Article

Recent clinical studies

Etiology

Clinical features of inflammatory bowel disease unclassified: a case-control study.
Shao Y, Zhao Y, Lv H, Yan P, Yang H, Li J, Li J, Qian J
BMC Gastroenterol 2024 Mar 13;24(1):105. doi: 10.1186/s12876-024-03171-5. PMID: 38481157Free PMC Article
Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Zhao L, Tang Y, Lei N, Zhou D, Chen B, Gan T, Yang X, Zhang Y
Scand J Gastroenterol 2020 Apr;55(4):442-448. Epub 2020 Apr 14 doi: 10.1080/00365521.2020.1748222. PMID: 32285715
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article

Diagnosis

Successful treatment of refractory enteritis and arthritis with combination of tumour necrosis factor and interleukin-6 inhibition in patients with ulcerative colitis.
Ishigaki S, Kondo Y, Ota Y, Chu PS, Hanaoka H, Takeuchi T, Kaneko Y
Mod Rheumatol Case Rep 2023 Dec 29;8(1):33-36. doi: 10.1093/mrcr/rxad031. PMID: 37300554
Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405
Campylobacter colitis.
Lambert ME, Schofield PF, Ironside AG, Mandal BK
Br Med J 1979 Mar 31;1(6167):857-9. doi: 10.1136/bmj.1.6167.857. PMID: 435842Free PMC Article

Therapy

Clinical features of inflammatory bowel disease unclassified: a case-control study.
Shao Y, Zhao Y, Lv H, Yan P, Yang H, Li J, Li J, Qian J
BMC Gastroenterol 2024 Mar 13;24(1):105. doi: 10.1186/s12876-024-03171-5. PMID: 38481157Free PMC Article
Jianpi Qingchang Bushen decoction improves inflammatory response and metabolic bone disorder in inflammatory bowel disease-induced bone loss.
Zhang YL, Chen Q, Zheng L, Zhang ZW, Chen YJ, Dai YC, Tang ZP
World J Gastroenterol 2022 Apr 7;28(13):1315-1328. doi: 10.3748/wjg.v28.i13.1315. PMID: 35645540Free PMC Article
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
The Apoptotic Crypt Abscess: An Underappreciated Histologic Finding in Gastrointestinal Pathology.
Talmon G, Manasek T, Miller R, Muirhead D, Lazenby A
Am J Clin Pathol 2017 Nov 20;148(6):538-544. doi: 10.1093/ajcp/aqx100. PMID: 29140405
Systemic lupus erythematosus complicated by Crohn's disease: a case report and literature review.
Yamashita H, Ueda Y, Kawaguchi H, Suzuki A, Takahashi Y, Kaneko H, Kano T, Mimori A
BMC Gastroenterol 2012 Dec 5;12:174. doi: 10.1186/1471-230X-12-174. PMID: 23216789Free PMC Article

Prognosis

Clinical features of inflammatory bowel disease unclassified: a case-control study.
Shao Y, Zhao Y, Lv H, Yan P, Yang H, Li J, Li J, Qian J
BMC Gastroenterol 2024 Mar 13;24(1):105. doi: 10.1186/s12876-024-03171-5. PMID: 38481157Free PMC Article
Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors.
Yanai S, Toya Y, Sugai T, Matsumoto T
Digestion 2021;102(6):965-973. Epub 2021 Sep 2 doi: 10.1159/000518543. PMID: 34515105
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up.
Windon AL, Almazan E, Oliva-Hemker M, Hutchings D, Assarzadegan N, Salimian K, Montgomery EA, Voltaggio L
Hum Pathol 2020 Dec;106:13-22. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.011. PMID: 32991931
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Gastrointestinal graft-versus-host disease in man. A clinicopathologic study of the rectal biopsy.
Sale GE, Shulman HM, McDonald GB, Thomas ED
Am J Surg Pathol 1979 Aug;3(4):291-9. doi: 10.1097/00000478-197908000-00001. PMID: 44107

Clinical prediction guides

Computed tomography enterocolongraphy in assessment of degree of ulcerative colitis activity.
Ahmed EA, Abdelatty K, Mahdy RE, Emara DM, Header DA
Int J Clin Pract 2021 Oct;75(10):e14626. Epub 2021 Jul 28 doi: 10.1111/ijcp.14626. PMID: 34258846
Clinical features and monocyte/macrophage subsets characterization in granulomatous vs non-granulomatous Crohn's disease.
Zhao L, Tang Y, Lei N, Zhou D, Chen B, Gan T, Yang X, Zhang Y
Scand J Gastroenterol 2020 Apr;55(4):442-448. Epub 2020 Apr 14 doi: 10.1080/00365521.2020.1748222. PMID: 32285715
Immune checkpoint inhibitor-induced diarrhea: Clinicopathological study of 11 patients.
Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T
Dig Endosc 2020 May;32(4):616-620. Epub 2019 Nov 12 doi: 10.1111/den.13555. PMID: 31595568
Endocytoscopic classification can be predictive for relapse in ulcerative colitis.
Ueda N, Isomoto H, Ikebuchi Y, Kurumi H, Kawaguchi K, Yashima K, Ueki M, Matsushima K, Akashi T, Uehara R, Takeshima F, Hayashi T, Nakao K
Medicine (Baltimore) 2018 Mar;97(10):e0107. doi: 10.1097/MD.0000000000010107. PMID: 29517688Free PMC Article
Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis.
Sokol H, Vasquez N, Hoyeau-Idrissi N, Seksik P, Beaugerie L, Lavergne-Slove A, Pochart P, Marteau P
World J Gastroenterol 2010 Feb 7;16(5):583-7. doi: 10.3748/wjg.v16.i5.583. PMID: 20128026Free PMC Article

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