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Malignant Ovarian Thecoma

MedGen UID:: 83139
•Concept ID:: C0334398
•: Neoplastic Process

Synonyms:	Malignant Ovarian Thecal Cell Neoplasm; Malignant Ovarian Thecal Cell Tumor; Malignant Thecal Cell Neoplasm of Ovary; Malignant Thecal Cell Neoplasm of the Ovary; Malignant Thecal Cell Tumor of Ovary; Malignant Thecal Cell Tumor of the Ovary; Malignant thecoma; Malignant Thecoma of Ovary; Malignant Thecoma of the Ovary; Thecoma, malignant
SNOMED CT:	Malignant thecoma (57622002); Thecoma, malignant (57622002)

Definition

A thecoma of the ovary which may metastasize to another anatomic site. It is usually characterized by nuclear atypia and mitotic activity. Malignant thecomas are rare. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Ovarian Thecoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Ovarian Thecoma
        Malignant Ovarian Luteinized Thecoma

Professional guidelines

PubMed

Luteinized thecomatosis and other conditions associated with sclerosing peritonitis: a problem in causation, management, and nomenclature.

Roth LM
Expert Rev Anticancer Ther 2021 Mar;21(3):239-240. Epub 2020 Dec 8 doi: 10.1080/14737140.2021.1853530. PMID: 33290110

Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.

Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Management of non-epithelial ovarian tumours.

Bridgewater JA, Rustin GJ
Oncology 1999;57(2):89-98. doi: 10.1159/000012014. PMID: 10461054

See all (18)

Recent clinical studies

Etiology

CT review of ovarian fibrothecoma.

Pat JJ, Rothnie KK, Kolomainen D, Sundaresan M, Zhang J, Liyanage SH
Br J Radiol 2022 Aug 1;95(1136):20210790. Epub 2022 Jul 12 doi: 10.1259/bjr.20210790. PMID: 35451310 Free PMC Article

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison.

Chen H, Liu Y, Shen LF, Jiang MJ, Yang ZF, Fang GP
J Ovarian Res 2016 Nov 22;9(1):81. doi: 10.1186/s13048-016-0291-2. PMID: 27876070 Free PMC Article

Imaging features and pathologic characteristics of ovarian thecoma.

Li X, Zhang W, Zhu G, Sun C, Liu Q, Shen Y
J Comput Assist Tomogr 2012 Jan-Feb;36(1):46-53. doi: 10.1097/RCT.0b013e31823f6186. PMID: 22261769

Perspectives on pure ovarian stromal neoplasms and tumor-like proliferations of the ovarian stroma.

Roth LM, Czernobilsky B
Am J Surg Pathol 2011 Mar;35(3):e15-33. doi: 10.1097/PAS.0b013e31820acb89. PMID: 21317704

See all (119)

Diagnosis

Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma.

Liu J, Wei J, Yang Y, Wei J
Medicine (Baltimore) 2023 Jun 9;102(23):e33911. doi: 10.1097/MD.0000000000033911. PMID: 37335673 Free PMC Article

Brenner tumors.

Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171 Free PMC Article

Ovarian Fibrothecoma.

Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246

Luteinized Fibrothecoma.

Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

See all (269)

Therapy

Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.

Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537

Sclerosing peritonitis associated with bilateral luteinized thecoma, linked to anticonvulsant therapy.

Levavi H, Sabah G, Heifetz M, Feinmesser M
Eur J Gynaecol Oncol 2009;30(6):695-700. PMID: 20099509

Management of non-epithelial ovarian tumours.

Bridgewater JA, Rustin GJ
Oncology 1999;57(2):89-98. doi: 10.1159/000012014. PMID: 10461054

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Endometrial "sarcomas" complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy.

Press MF, Scully RE
Gynecol Oncol 1985 Jun;21(2):135-54. doi: 10.1016/0090-8258(85)90246-x. PMID: 2985476

See all (32)

Prognosis

Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes.

Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445 Free PMC Article

Comprehensive review of imaging features of sex cord-stromal tumors of the ovary.

Javadi S, Ganeshan DM, Jensen CT, Iyer RB, Bhosale PR
Abdom Radiol (NY) 2021 Apr;46(4):1519-1529. Epub 2021 Mar 16 doi: 10.1007/s00261-021-02998-w. PMID: 33725145

Ovarian Fibrothecoma.

Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246

Practical Review of Ovarian Sex Cord-Stromal Tumors.

Hanley KZ, Mosunjac MB
Surg Pathol Clin 2019 Jun;12(2):587-620. doi: 10.1016/j.path.2019.02.005. PMID: 31097116

Adnexal masses encountered during cesarean delivery.

Baser E, Erkilinc S, Esin S, Togrul C, Biberoglu E, Karaca MZ, Gungor T, Danisman N
Int J Gynaecol Obstet 2013 Nov;123(2):124-6. Epub 2013 Aug 14 doi: 10.1016/j.ijgo.2013.06.015. PMID: 24008309

See all (86)

Clinical prediction guides

MRI combined with clinical features to differentiate ovarian thecoma-fibroma with cystic degeneration from ovary adenofibroma.

Bo J, Sun M, Wei C, Wei L, Fu B, Shi B, Fang X, Dong J
Br J Radiol 2024 May 7;97(1157):1057-1065. doi: 10.1093/bjr/tqae046. PMID: 38402483 Free PMC Article

Early diagnosis of Meigs syndrome in children A case report and a review of the literature.

Brillantino C, Errico ME, Minelli R, Esposito F, Pirisi P, Gaglione G, Grella MG, Ferrara D, Zeccolini M, Rossi E
Ann Ital Chir 2022 Jul 25;11 PMID: 36606361

Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes.

Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445 Free PMC Article

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.

Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284

Transplantation of reproductive organs.

Lee S, Mao L, Wang Y, D'Silva M, Yoo CH, Wolf P, Chung WS, Takahashi E, Chung DY, Gittes RF
Microsurgery 1995;16(4):191-8. doi: 10.1002/micr.1920160406. PMID: 7674907

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Recent systematic reviews

Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years.

Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M
Expert Rev Anticancer Ther 2021 Jan;21(1):23-32. Epub 2020 Oct 22 doi: 10.1080/14737140.2021.1837629. PMID: 33053314

Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.

Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

See all (2)

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