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Spermatocytic seminoma

MedGen UID:
83159
•Concept ID:
C0334517
•
Neoplastic Process
Synonym: Spermatocytic seminoma, somatic
SNOMED CT: Spermatocytic seminoma (9294008); Spermatocytoma (9294008)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0020513
OMIM®: 273300
Orphanet: ORPHA99865

Definition

Spermatocytic seminoma (SS) is an extremely rare form of testicular cancer distinguished from testicular seminomatous germ cell tumors (see this term) by a very low rate of metastasis and lack of an ovarian equivalent. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Spermatocytic seminoma
Follow this link to review classifications for Spermatocytic seminoma in Orphanet.

Professional guidelines

PubMed

Contemporary Trends in Presentation and Management of Spermatocytic Seminoma.
Patel PM, Patel HD, Koehne EL, Doshi C, Belshoff A, Seffren CM, Baker M, Gorbonos A, Gupta G
Urology 2020 Dec;146:177-182. Epub 2020 Oct 10 doi: 10.1016/j.urology.2020.10.002. PMID: 33049234
A systematic review of treatment outcomes in localised and metastatic spermatocytic tumors of the testis.
Grogg JB, Schneider K, Bode PK, Wettstein MS, Kranzbühler B, Eberli D, Sulser T, Beyer J, Hermanns T, Fankhauser CD
J Cancer Res Clin Oncol 2019 Dec;145(12):3037-3045. Epub 2019 Oct 23 doi: 10.1007/s00432-019-03056-1. PMID: 31646373
Management of clinical stage I testicular pure seminoma. Report on 42 patients and review of the literature.
Porcaro AB, Antoniolli SZ, Schiavone D, Maffei N, Bassetto MA, Curti P
Arch Ital Urol Androl 2002 Jun;74(2):77-80. PMID: 12161941

Recent clinical studies

Etiology

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Contemporary Trends in Presentation and Management of Spermatocytic Seminoma.
Patel PM, Patel HD, Koehne EL, Doshi C, Belshoff A, Seffren CM, Baker M, Gorbonos A, Gupta G
Urology 2020 Dec;146:177-182. Epub 2020 Oct 10 doi: 10.1016/j.urology.2020.10.002. PMID: 33049234
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives.
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Update on the pathology of testicular tumors.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):75-85. PMID: 26072638

Diagnosis

Spermatocytic Tumor: A Review.
Secondino S, Viglio A, Neri G, Galli G, Faverio C, Mascaro F, Naspro R, Rosti G, Pedrazzoli P
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119529. PMID: 37298487Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives.
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Spermatocytic seminoma.
Eble JN
Hum Pathol 1994 Oct;25(10):1035-42. doi: 10.1016/0046-8177(94)90062-0. PMID: 7927308

Therapy

Prognostic and predictive factors in testicular cancer.
Facchini G, Rossetti S, Berretta M, Cavaliere C, D'Aniello C, Iovane G, Mollo G, Capasso M, Della Pepa C, Pesce L, Facchini S, Imbimbo C, Pisconti S
Eur Rev Med Pharmacol Sci 2019 May;23(9):3885-3891. doi: 10.26355/eurrev_201905_17816. PMID: 31115016
Cellular evidence for selfish spermatogonial selection in aged human testes.
Maher GJ, Goriely A, Wilkie AO
Andrology 2014 May;2(3):304-14. Epub 2013 Dec 19 doi: 10.1111/j.2047-2927.2013.00175.x. PMID: 24357637
Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma.
Horn T, Schulz S, Maurer T, Gschwend JE, Kübler HR
Med Oncol 2011 Dec;28 Suppl 1:S423-5. Epub 2010 Nov 18 doi: 10.1007/s12032-010-9739-1. PMID: 21086073
Treatment of early stage testicular seminoma.
Classen J, Souchon R, Hehr T, Bamberg M
J Cancer Res Clin Oncol 2001 Aug;127(8):475-81. doi: 10.1007/s004320100243. PMID: 11501746
Anaplastic seminoma and spermatocytic seminoma--a retrospective analysis.
Stein M, Dale J, Kuten A, Moshkowitz B
S Afr J Surg 1993 Dec;31(4):144-6. PMID: 8122181

Prognosis

Spermatocytic Tumor: A Review.
Secondino S, Viglio A, Neri G, Galli G, Faverio C, Mascaro F, Naspro R, Rosti G, Pedrazzoli P
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119529. PMID: 37298487Free PMC Article
Contemporary Trends in Presentation and Management of Spermatocytic Seminoma.
Patel PM, Patel HD, Koehne EL, Doshi C, Belshoff A, Seffren CM, Baker M, Gorbonos A, Gupta G
Urology 2020 Dec;146:177-182. Epub 2020 Oct 10 doi: 10.1016/j.urology.2020.10.002. PMID: 33049234
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing Its Morphologic Spectrum Including Some Aspects Not Widely Known.
Hu R, Ulbright TM, Young RH
Am J Surg Pathol 2019 Jan;43(1):1-11. doi: 10.1097/PAS.0000000000001001. PMID: 29280854
Carcinoma in situ in the testis.
Rørth M, Rajpert-De Meyts E, Andersson L, Dieckmann KP, Fosså SD, Grigor KM, Hendry WF, Herr HW, Looijenga LH, Oosterhuis JW, Skakkebaek NE
Scand J Urol Nephrol Suppl 2000;(205):166-86. doi: 10.1080/00365590050509896. PMID: 11144894
Spermatocytic seminoma.
Weitzner S
Urology 1976 Jun;7(6):646-8. doi: 10.1016/0090-4295(76)90095-9. PMID: 936388

Clinical prediction guides

Prognostic and predictive factors in testicular cancer.
Facchini G, Rossetti S, Berretta M, Cavaliere C, D'Aniello C, Iovane G, Mollo G, Capasso M, Della Pepa C, Pesce L, Facchini S, Imbimbo C, Pisconti S
Eur Rev Med Pharmacol Sci 2019 May;23(9):3885-3891. doi: 10.26355/eurrev_201905_17816. PMID: 31115016
Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization.
Ulbright TM
Arch Pathol Lab Med 2019 Jun;143(6):711-721. Epub 2018 Jun 27 doi: 10.5858/arpa.2017-0478-RA. PMID: 29949388
Testicular and testicular adnexa tumors in the elderly.
Gigantino V, La Mantia E, Franco R, Cecere S, Rossetti S, Di Napoli M, Pisano C, Berretta M, Galzerano A, Botti G, Pignata S, Facchini G
Anticancer Drugs 2013 Mar;24(3):228-36. doi: 10.1097/CAD.0b013e32835a3598. PMID: 23059385
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Spermatocytic seminoma: a review.
Chung PW, Bayley AJ, Sweet J, Jewett MA, Tew-George B, Gospodarowicz MK, Warde PR
Eur Urol 2004 Apr;45(4):495-8. doi: 10.1016/j.eururo.2003.11.005. PMID: 15041115

Recent systematic reviews

A systematic review of treatment outcomes in localised and metastatic spermatocytic tumors of the testis.
Grogg JB, Schneider K, Bode PK, Wettstein MS, Kranzbühler B, Eberli D, Sulser T, Beyer J, Hermanns T, Fankhauser CD
J Cancer Res Clin Oncol 2019 Dec;145(12):3037-3045. Epub 2019 Oct 23 doi: 10.1007/s00432-019-03056-1. PMID: 31646373

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