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Ovarian seromucinous tumor

MedGen UID:
83409
•Concept ID:
C0346166
•
Neoplastic Process
Synonyms: mixed epithelial neoplasm of ovary; mixed epithelial neoplasm of the ovary; Mixed epithelial tumor of ovary; mixed epithelial tumor of ovary; mixed epithelial tumor of the ovary; mixed epithelial tumour of ovary; mixed epithelial tumour of the ovary; ovarian mixed epithelial neoplasm; ovarian mixed epithelial tumor; ovarian mixed epithelial tumour; Ovarian Seromucinous Tumor; ovarian seromucinous tumor; ovarian Seromucinous tumor; ovarian Seromucinous tumour
SNOMED CT: Mixed epithelial tumor of ovary (254855000)
 
Monarch Initiative: MONDO:0003811

Definition

A benign, borderline, or malignant mixed epithelial tumor of the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous. [from NCI]

Professional guidelines

PubMed

Management of Borderline ovarian tumors (BOT): results of a retrospective, single center study in Switzerland.
Kipp B, Vidal A, Lenick D, Christmann-Schmid C
J Ovarian Res 2023 Jan 23;16(1):20. doi: 10.1186/s13048-023-01107-3. PMID: 36691070Free PMC Article
Magnetic resonance imaging findings of cystic ovarian tumors: major differential diagnoses in five types frequently encountered in daily clinical practice.
Ohya A, Fujinaga Y
Jpn J Radiol 2022 Dec;40(12):1213-1234. Epub 2022 Aug 2 doi: 10.1007/s11604-022-01321-x. PMID: 35916971Free PMC Article
Clinical Features and Management of Women with Borderline Ovarian Tumors in a Single Center in Brazil.
Yoshida A, Tavares BVG, Sarian LO, Andrade LALÂ, Derchain SF
Rev Bras Ginecol Obstet 2019 Mar;41(3):176-182. Epub 2019 Apr 16 doi: 10.1055/s-0039-1683415. PMID: 30991432Free PMC Article

Recent clinical studies

Etiology

PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis.
Yun BS, Won S, Kim JH, Lee N, Kim M, Kim MK, Kim ML, Jung YW, Kim JY, Seong SJ, Shin E
J Ovarian Res 2022 Apr 6;15(1):41. doi: 10.1186/s13048-022-00975-5. PMID: 35387670Free PMC Article
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216
The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.
Kurman RJ, Shih IeM
Am J Pathol 2016 Apr;186(4):733-47. doi: 10.1016/j.ajpath.2015.11.011. PMID: 27012190Free PMC Article
Seromucinous Tumors of the Ovary. What's in a Name?
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2016 Jan;35(1):78-81. doi: 10.1097/PGP.0000000000000266. PMID: 26598986Free PMC Article

Diagnosis

Ovarian seromucinous carcinoma: an independent epithelial ovarian cancer?
Hu Y, Fu K, Liu H, He Q, Qiu X, Yang W, Zhang Y
J Ovarian Res 2023 Jan 20;16(1):18. doi: 10.1186/s13048-023-01100-w. PMID: 36670456Free PMC Article
Ovarian mucinous and seromucinous neoplasms: problematic aspects and modern diagnostic approach.
Talia KL, Parra-Herran C, McCluggage WG
Histopathology 2022 Jan;80(2):255-278. Epub 2021 Oct 20 doi: 10.1111/his.14399. PMID: 33963606
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Cancer Implications for Patients with Endometriosis.
Wilbur MA, Shih IM, Segars JH, Fader AN
Semin Reprod Med 2017 Jan;35(1):110-116. Epub 2017 Jan 3 doi: 10.1055/s-0036-1597120. PMID: 28049216

Therapy

New sonographic marker of borderline ovarian tumor: microcystic pattern of papillae and solid components.
Timor-Tritsch IE, Foley CE, Brandon C, Yoon E, Ciaffarrano J, Monteagudo A, Mittal K, Boyd L
Ultrasound Obstet Gynecol 2019 Sep;54(3):395-402. Epub 2019 Aug 8 doi: 10.1002/uog.20283. PMID: 30950132
Morphologic Reproducibility, Genotyping, and Immunohistochemical Profiling Do Not Support a Category of Seromucinous Carcinoma of the Ovary.
Rambau PF, McIntyre JB, Taylor J, Lee S, Ogilvie T, Sienko A, Morris D, Duggan MA, McCluggage WG, Köbel M
Am J Surg Pathol 2017 May;41(5):685-695. doi: 10.1097/PAS.0000000000000812. PMID: 28125452
Characteristics of ovarian and uterine cancers in a cohort of in vitro fertilization patients.
Venn A, Jones P, Quinn M, Healy D
Gynecol Oncol 2001 Jul;82(1):64-8. doi: 10.1006/gyno.2001.6209. PMID: 11426963
Oral contraceptive use and benign gynecologic conditions. A review.
Chiaffarino F, Parazzini F, La Vecchia C, Ricci E, Crosignani PG
Contraception 1998 Jan;57(1):11-8. doi: 10.1016/s0010-7824(97)00201-1. PMID: 9554245
Risk factors for seromucinous benign ovarian cysts in northern Italy.
Parazzini F, Moroni S, Negri E, La Vecchia C, Mezzopane R, Crosignani PG
J Epidemiol Community Health 1997 Aug;51(4):449-52. doi: 10.1136/jech.51.4.449. PMID: 9328556Free PMC Article

Prognosis

Ovarian seromucinous carcinoma: an independent epithelial ovarian cancer?
Hu Y, Fu K, Liu H, He Q, Qiu X, Yang W, Zhang Y
J Ovarian Res 2023 Jan 20;16(1):18. doi: 10.1186/s13048-023-01100-w. PMID: 36670456Free PMC Article
Clinicopathological Characteristics and Prognosis of 91 Patients with Seromucinous and Mucinous Borderline Ovarian Tumors: a Comparative Study.
Wu B, Li J, Tao X, Wang J, Zhu G, Lu X, Chen R
Reprod Sci 2023 Jun;30(6):1927-1937. Epub 2022 Dec 13 doi: 10.1007/s43032-022-01114-7. PMID: 36512190
Synchronous Occurrence of Ovarian Seromucinous Carcinoma and Endometrial Mucinous Carcinoma: A Case Report.
Urakawa R, Harada H, Tohyama A, Aoyama Y, Kinjo Y, Hoshino K, Ueda T, Kagami S, Tsukamoto J, Aoki T, Iwamura R, Hisaoka M, Matsuura Y, Yoshino K
J UOEH 2021;43(2):235-242. doi: 10.7888/juoeh.43.235. PMID: 34092768
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors.
Karpathiou G, Chauleur C, Corsini T, Venet M, Habougit C, Honeyman F, Forest F, Peoc'h M
Ann Diagn Pathol 2017 Apr;27:28-33. Epub 2017 Jan 7 doi: 10.1016/j.anndiagpath.2017.01.002. PMID: 28325358

Clinical prediction guides

Clinicopathological Characteristics and Prognosis of 91 Patients with Seromucinous and Mucinous Borderline Ovarian Tumors: a Comparative Study.
Wu B, Li J, Tao X, Wang J, Zhu G, Lu X, Chen R
Reprod Sci 2023 Jun;30(6):1927-1937. Epub 2022 Dec 13 doi: 10.1007/s43032-022-01114-7. PMID: 36512190
Clinicopathologic Features and the Loss of ARID1A Expression in Ovarian Seromucinous Borderline Tumors and Seromucinous Carcinomas.
Ok Atılgan A, Özen Ö, Haberal Reyhan AN, Ayhan A
Int J Surg Pathol 2023 Jun;31(4):398-408. Epub 2022 Nov 30 doi: 10.1177/10668969221134695. PMID: 36452965
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Differentiation of Seromucinous Borderline Tumor from Serous Borderline Tumor on MR Imaging.
Kurata Y, Kido A, Moribata Y, Kameyama K, Minamiguchi S, Konishi I, Togashi K
Magn Reson Med Sci 2018 Jul 10;17(3):211-217. Epub 2017 Oct 6 doi: 10.2463/mrms.mp.2017-0055. PMID: 28993546Free PMC Article
Seromucinous ovarian tumor A comparison with the rest of ovarian epithelial tumors.
Karpathiou G, Chauleur C, Corsini T, Venet M, Habougit C, Honeyman F, Forest F, Peoc'h M
Ann Diagn Pathol 2017 Apr;27:28-33. Epub 2017 Jan 7 doi: 10.1016/j.anndiagpath.2017.01.002. PMID: 28325358

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