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Adult pineal parenchymal tumor

MedGen UID:
83710
•Concept ID:
C0280794
•
Neoplastic Process
Synonyms: Adult Pineal Gland Neoplasm; adult pineal gland neoplasm; Adult Pineal Gland Tumor; adult pineal gland tumor; adult pineal gland tumour; Adult Pineal Parenchymal Cell Neoplasm; adult pineal parenchymal cell neoplasm; Adult Pineal Parenchymal Cell Tumor; adult pineal parenchymal cell tumor; adult pineal parenchymal cell tumour; Adult Pineal Parenchymal Neoplasm; adult pineal parenchymal neoplasm; Adult Pineal Parenchymal Tumor; adult pineal parenchymal tumor; Parenchymal Neoplasm of Adult Pineal Gland; parenchymal neoplasm of adult pineal gland; Parenchymal Neoplasm of the Adult Pineal Gland; parenchymal neoplasm of the adult pineal gland; Parenchymal Tumor of Adult Pineal Gland; parenchymal tumor of adult pineal gland; Parenchymal Tumor of the Adult Pineal Gland; parenchymal tumor of the adult pineal gland; parenchymal tumour of adult pineal gland; parenchymal tumour of the adult pineal gland; pineal parenchymal cell neoplasm of adults
 
Monarch Initiative: MONDO:0003248

Definition

A pineal parenchymal cell neoplasm (pineocytoma or pineoblastoma) occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult pineal parenchymal tumor

Professional guidelines

PubMed

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Pineal Region Glioblastomas: Clinical Characteristics, Treatment, and Survival Outcome.
Niu X, Wang C, Zhou X, Yang Y, Liu Y, Zhang Y, Mao Q
World Neurosurg 2021 Feb;146:e799-e810. Epub 2020 Nov 10 doi: 10.1016/j.wneu.2020.11.016. PMID: 33186787
Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934

Recent clinical studies

Etiology

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Diagnosis

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Pineal parenchymal tumours and pineal cysts.
Jouvet A, Vasiljevic A, Champier J, Fèvre Montange M
Neurochirurgie 2015 Apr-Jun;61(2-3):123-9. Epub 2014 Jun 27 doi: 10.1016/j.neuchi.2013.04.003. PMID: 24975206
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982

Therapy

Neurosurgical application of pineal region tumor resection with 3D 4K exoscopy via infratentorial approach: a retrospective cohort study.
Hua W, Zhang X, Wang Q, Qiu T, Yang Z, Wang X, Xu H, Zhang J, Yu G, Fu M, Chen L, Zhu W, Mao Y
Int J Surg 2023 Dec 1;109(12):4062-4072. doi: 10.1097/JS9.0000000000000707. PMID: 37755386Free PMC Article
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.
Liu APY, Gudenas B, Lin T, Orr BA, Klimo P Jr, Kumar R, Bouffet E, Gururangan S, Crawford JR, Kellie SJ, Chintagumpala M, Fisher MJ, Bowers DC, Hassall T, Indelicato DJ, Onar-Thomas A, Ellison DW, Boop FA, Merchant TE, Robinson GW, Northcott PA, Gajjar A
Acta Neuropathol 2020 Feb;139(2):259-271. Epub 2019 Dec 4 doi: 10.1007/s00401-019-02106-9. PMID: 31802236Free PMC Article
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646

Prognosis

Clinical experience and outcomes in patients with pineal parenchymal tumor of intermediate differentiation (PPTID): a single-institution analysis.
Webb M, Johnson DR, Mahajan A, Brown P, Neth B, Kizilbash SH, Sener U
J Neurooncol 2022 Nov;160(2):527-534. Epub 2022 Oct 27 doi: 10.1007/s11060-022-04174-6. PMID: 36301435
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors.
Lutterbach J, Fauchon F, Schild SE, Chang SM, Pagenstecher A, Volk B, Ostertag C, Momm F, Jouvet A
Neurosurgery 2002 Jul;51(1):44-55; discussion 55-6. doi: 10.1097/00006123-200207000-00006. PMID: 12182434
Pineal tumors.
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Pineocytomas.
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Clinical prediction guides

Concomitant, Single Burr Hole Endoscopic Third Ventriculostomy and Tumor Biopsy for Pineal Lesions: Feasibility, Safety, and Benefits.
Leone A, Colamaria A, Fochi NP, Di Napoli V, Blagia M, Sacco M, Winkler G, Spetzger U, Almerayed W, Carbone F
World Neurosurg 2023 May;173:5-11. Epub 2023 Feb 9 doi: 10.1016/j.wneu.2023.01.082. PMID: 36764448
Pineal germinoma in a young adult: A case report.
Fernández-Rodríguez LJ, Maldonado-Pijoan X
Cancer Rep (Hoboken) 2022 Sep;5(9):e1611. Epub 2022 Mar 28 doi: 10.1002/cnr2.1611. PMID: 35347869Free PMC Article
Malignant Pineal Parenchymal Tumors in Adults: A National Cancer Database Analysis.
Chalif EJ, Murray RD, Mozaffari K, Chillakuru YR, Shim T, Monfared A, Sherman JH
Neurosurgery 2022 Jun 1;90(6):807-815. Epub 2022 Mar 23 doi: 10.1227/neu.0000000000001915. PMID: 35311743
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Pathologic Prognostic Factors of Pineal Parenchymal Tumor of Intermediate Differentiation.
Chatterjee D, Lath K, Singla N, Kumar N, Radotra BD
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):210-215. doi: 10.1097/PAI.0000000000000565. PMID: 28800009

Recent systematic reviews

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Papillary tumor of the pineal region in pediatric populations: An additional case and systematic review of a rare tumor entity.
Mathkour M, Hanna J, Ibrahim N, Scullen T, Kilgore MD, Werner C, Cormier I, Spencer P, Keen JR, Bui CJ
Clin Neurol Neurosurg 2021 Feb;201:106404. Epub 2020 Dec 8 doi: 10.1016/j.clineuro.2020.106404. PMID: 33360024
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.
Leroy R, Benahmed N, Hulstaert F, Van Damme N, De Ruysscher D
Int J Radiat Oncol Biol Phys 2016 May 1;95(1):267-278. Epub 2015 Oct 17 doi: 10.1016/j.ijrobp.2015.10.025. PMID: 27084646

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