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Lip carcinoma in situ

MedGen UID:
83849
•Concept ID:
C0347082
•
Neoplastic Process
Synonyms: Carcinoma in situ of Lip; carcinoma in situ of lip; Carcinoma in situ of the Lip; carcinoma in situ of the Lip; Lip Carcinoma in situ; lip carcinoma in situ; lip in situ carcinoma; Stage 0 Cancer of Lip; stage 0 cancer of Lip; Stage 0 Cancer of the Lip; stage 0 cancer of the Lip; Stage 0 Carcinoma of Lip; stage 0 carcinoma of Lip; Stage 0 Carcinoma of the Lip; stage 0 carcinoma of the Lip; Stage 0 Lip Cancer; stage 0 Lip cancer; Stage 0 Lip Cancer AJCC v6; stage 0 Lip cancer aJCC v6; Stage 0 Lip Cancer AJCC v6 and v7; stage 0 Lip cancer aJCC v6 and v7; Stage 0 Lip Cancer AJCC v7; stage 0 Lip cancer aJCC v7; Stage 0 Lip Carcinoma; stage 0 lip carcinoma
 
Monarch Initiative: MONDO:0004636

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip carcinoma in situ

Professional guidelines

PubMed

Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases.
Rossini RC, Dellatorre G, Mesquita LAF, Tarlé RG
J Dermatolog Treat 2021 Dec;32(8):1049-1052. Epub 2020 Feb 27 doi: 10.1080/09546634.2020.1724865. PMID: 32072836
Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience.
Mignogna MD, Lo Muzio L, Lo Russo L, Fedele S, Ruoppo E, Bucci E
Oral Oncol 2001 Apr;37(3):262-7. doi: 10.1016/s1368-8375(00)00096-8. PMID: 11287280

Recent clinical studies

Etiology

Invasive and in situ squamous cell carcinoma of the skin: a nationwide study in Iceland.
Adalsteinsson JA, Olafsdottir E, Ratner D, Waldman R, Feng H, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2021 Sep;185(3):537-547. Epub 2021 May 9 doi: 10.1111/bjd.19879. PMID: 33609287
SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center.
Neves-Silva R, Almeida LY, Silveira HA, Colturato CBN, Duarte A, Ferrisse TM, Silva EV, Vanzolin BF, Bufalino A, Ribeiro-Silva A, León JE
Head Neck 2020 Mar;42(3):374-384. Epub 2019 Nov 15 doi: 10.1002/hed.26008. PMID: 31729110
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Biology and pathological associations of the human papillomaviruses: a review.
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257
Oral carcinoma in situ.
Waldron CA, Shafer WG
Oral Surg Oral Med Oral Pathol 1975 Feb;39(2):227-38. doi: 10.1016/0030-4220(75)90224-8. PMID: 1054449

Diagnosis

Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Sebaceous Carcinoma of the Vulva: An Unexpected Diagnosis and Literature Review.
Rocha AC, Sá MI, Abrantes C, Sousa R
Acta Med Port 2022 Jan 3;35(1):63-67. doi: 10.20344/amp.13551. PMID: 35225764
Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland: Two case reports.
Ogawa M, Yokoo S, Yamaguchi T, Suzuki K, Seki-Soda M, Shimizu T, Kurihara J, Makiguchi T
Medicine (Baltimore) 2021 Dec 23;100(51):e28390. doi: 10.1097/MD.0000000000028390. PMID: 34941172Free PMC Article
SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center.
Neves-Silva R, Almeida LY, Silveira HA, Colturato CBN, Duarte A, Ferrisse TM, Silva EV, Vanzolin BF, Bufalino A, Ribeiro-Silva A, León JE
Head Neck 2020 Mar;42(3):374-384. Epub 2019 Nov 15 doi: 10.1002/hed.26008. PMID: 31729110
Oral carcinoma in situ.
Waldron CA, Shafer WG
Oral Surg Oral Med Oral Pathol 1975 Feb;39(2):227-38. doi: 10.1016/0030-4220(75)90224-8. PMID: 1054449

Therapy

5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Wang P, Zhang G, Zhang L, Zhou Z, Shi L, Zeng Q, Zhu L, Wang X
Photodiagnosis Photodyn Ther 2021 Sep;35:102321. Epub 2021 May 17 doi: 10.1016/j.pdpdt.2021.102321. PMID: 34015543
Surgery sequential with 5-Aminolevulinic acid photodynamic therapy for lip squamous cell carcinoma: Two cases reports.
Yan J, Wang P, Li L, Zhang L, Zhang G, Tang Y, Wang X
Photodiagnosis Photodyn Ther 2020 Dec;32:102043. Epub 2020 Oct 1 doi: 10.1016/j.pdpdt.2020.102043. PMID: 33010483
Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute.
Tealab SH, Sedhom NFH, Hassouna A, Gouda I, Ismail H
J Investig Med 2019 Oct;67(7):1061-1066. Epub 2019 Mar 13 doi: 10.1136/jim-2018-000968. PMID: 30867228
Risk of lip cancer after solid organ transplantation in the United States.
Laprise C, Cahoon EK, Lynch CF, Kahn AR, Copeland G, Gonsalves L, Madeleine MM, Pfeiffer RM, Engels EA
Am J Transplant 2019 Jan;19(1):227-237. Epub 2018 Sep 5 doi: 10.1111/ajt.15052. PMID: 30074684Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

Prognosis

Risk Factors and Prognosis for Metastatic Cutaneous Squamous Cell Carcinoma: A Cohort Study.
Knuutila JS, Riihilä P, Kurki S, Nissinen L, Kähäri VM
Acta Derm Venereol 2020 Sep 23;100(16):adv00266. doi: 10.2340/00015555-3628. PMID: 32930344Free PMC Article
SMARCB1 (INI-1) and NUT immunoexpression in a large series of head and neck carcinomas in a Brazilian reference center.
Neves-Silva R, Almeida LY, Silveira HA, Colturato CBN, Duarte A, Ferrisse TM, Silva EV, Vanzolin BF, Bufalino A, Ribeiro-Silva A, León JE
Head Neck 2020 Mar;42(3):374-384. Epub 2019 Nov 15 doi: 10.1002/hed.26008. PMID: 31729110
Revisiting lip shave: a solution for disorders of the vermilion border.
Sayan A, Wijesinghe S, Paraneetharan S, Ilankovan V
Br J Oral Maxillofac Surg 2018 Jan;56(1):60-63. Epub 2017 Dec 6 doi: 10.1016/j.bjoms.2017.11.014. PMID: 29223636
Head and neck in situ carcinoma: incidence, trends, and survival.
Reid BC, Winn DM, Morse DE, Pendrys DG
Oral Oncol 2000 Sep;36(5):414-20. doi: 10.1016/s1368-8375(00)00028-2. PMID: 10964047
Biology and pathological associations of the human papillomaviruses: a review.
Cheah PL, Looi LM
Malays J Pathol 1998 Jun;20(1):1-10. PMID: 10879257

Clinical prediction guides

Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights.
Vageli D, Doukas PG, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M
Head Neck Pathol 2023 Jun;17(2):331-338. Epub 2022 Oct 27 doi: 10.1007/s12105-022-01504-y. PMID: 36303015Free PMC Article
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases.
Rossini RC, Dellatorre G, Mesquita LAF, Tarlé RG
J Dermatolog Treat 2021 Dec;32(8):1049-1052. Epub 2020 Feb 27 doi: 10.1080/09546634.2020.1724865. PMID: 32072836
Discoid lupus erythematosus with squamous cell carcinoma: a case report and review of the literature in Indian patients.
Fernandes MS, Girisha BS, Viswanathan N, Sripathi H, Noronha TM
Lupus 2015 Dec;24(14):1562-6. Epub 2015 Aug 6 doi: 10.1177/0961203315599245. PMID: 26251401
Grading oral epithelial dysplasia: analysis of individual features.
Tilakaratne WM, Sherriff M, Morgan PR, Odell EW
J Oral Pathol Med 2011 Aug;40(7):533-40. Epub 2011 Apr 18 doi: 10.1111/j.1600-0714.2011.01033.x. PMID: 21501232
Oral dysplasia and in situ carcinoma: clinicopathologic correlations of eight patients.
Hayward JR, Regezi JA
J Oral Surg 1977 Sep;35(9):756-62. PMID: 267762

Recent systematic reviews

Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.
Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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