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Carcinoma in situ of oropharynx

MedGen UID:
83852
•Concept ID:
C0347099
•
Neoplastic Process
Synonyms: Cancer in situ of oropharynx; Carcinoma in situ of mesopharynx; Carcinoma in situ of Oropharynx; carcinoma in situ of oropharynx; Carcinoma in situ of the Oropharynx; carcinoma in situ of the oropharynx; Carcinoma situ of oropharynx; Oropharyngeal Cancer Stage 0; oropharyngeal cancer stage 0; Oropharyngeal Carcinoma in situ; oropharyngeal carcinoma in situ; Oropharynx Carcinoma in situ; oropharynx carcinoma in situ; oropharynx in situ carcinoma; Stage 0 Carcinoma of Oropharynx; stage 0 carcinoma of oropharynx; Stage 0 Carcinoma of the Oropharynx; stage 0 carcinoma of the oropharynx; Stage 0 Oropharyngeal Cancer; stage 0 oropharyngeal cancer; Stage 0 Oropharyngeal Carcinoma; stage 0 oropharyngeal carcinoma; Stage 0 Oropharyngeal Carcinoma AJCC v6; stage 0 oropharyngeal carcinoma aJCC v6; Stage 0 Oropharyngeal Carcinoma AJCC v6 and v7; stage 0 oropharyngeal carcinoma aJCC v6 and v7; Stage 0 Oropharyngeal Carcinoma AJCC v7; stage 0 oropharyngeal carcinoma aJCC v7; stage 0 oropharyngeal carcinoma in situ; stage 0 oropharyngeal throat cancer; Stage 0 Oropharynx Carcinoma; stage 0 oropharynx carcinoma
SNOMED CT: Carcinoma situ of oropharynx (92668003); Carcinoma in situ of mesopharynx (92668003); Carcinoma in situ of oropharynx (92668003); Cancer in situ of oropharynx (92668003)
 
Monarch Initiative: MONDO:0021298

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma in situ of oropharynx

Professional guidelines

PubMed

Comprehensive management of HPV-related squamous cell carcinoma of the head and neck of unknown primary.
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Early detection, diagnosis, and management of oral and oropharyngeal cancer.
Mashberg A, Samit AM
CA Cancer J Clin 1989 Mar-Apr;39(2):67-88. doi: 10.3322/canjclin.39.2.67. PMID: 2495159

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Human papillomavirus as a driver of head and neck cancers.
Sabatini ME, Chiocca S
Br J Cancer 2020 Feb;122(3):306-314. Epub 2019 Nov 11 doi: 10.1038/s41416-019-0602-7. PMID: 31708575Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Diagnosis

HPV-related carcinoma of the oropharynx: challenges on small biopsy specimens.
Palsgrove D, Bishop JA
J Am Soc Cytopathol 2020 Sep-Oct;9(5):359-368. Epub 2020 Jun 19 doi: 10.1016/j.jasc.2020.06.001. PMID: 32651129
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Human papillomavirus as a driver of head and neck cancers.
Sabatini ME, Chiocca S
Br J Cancer 2020 Feb;122(3):306-314. Epub 2019 Nov 11 doi: 10.1038/s41416-019-0602-7. PMID: 31708575Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Therapy

Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute.
Tealab SH, Sedhom NFH, Hassouna A, Gouda I, Ismail H
J Investig Med 2019 Oct;67(7):1061-1066. Epub 2019 Mar 13 doi: 10.1136/jim-2018-000968. PMID: 30867228
Evaluating the PD-1 Axis and Immune Effector Cell Infiltration in Oropharyngeal Squamous Cell Carcinoma.
Schoenfeld JD, Gjini E, Rodig SJ, Tishler RB, Rawal B, Catalano PJ, Uppaluri R, Haddad RI, Hanna GJ, Chau NG, Rabinowits G, Lorch J, Jo VY, Krane JF, Goguen LA, Annino DJ, Abdelrahman S, Lipschitz M, Margalit DN
Int J Radiat Oncol Biol Phys 2018 Sep 1;102(1):137-145. Epub 2018 Jun 29 doi: 10.1016/j.ijrobp.2018.05.002. PMID: 29960819
HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior.
Kraft S, Faquin WC, Krane JF
Am J Surg Pathol 2012 Mar;36(3):321-30. doi: 10.1097/PAS.0b013e31823f2f17. PMID: 22301491
Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients.
Karakullukcu B, van Oudenaarde K, Copper MP, Klop WM, van Veen R, Wildeman M, Bing Tan I
Eur Arch Otorhinolaryngol 2011 Feb;268(2):281-8. Epub 2010 Aug 13 doi: 10.1007/s00405-010-1361-5. PMID: 20706842Free PMC Article
Early diagnosis of asymptomatic oral and oropharyngeal squamous cancers.
Mashberg A, Samit A
CA Cancer J Clin 1995 Nov-Dec;45(6):328-51. doi: 10.3322/canjclin.45.6.328. PMID: 7583906

Prognosis

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
HPV-related carcinoma of the oropharynx: challenges on small biopsy specimens.
Palsgrove D, Bishop JA
J Am Soc Cytopathol 2020 Sep-Oct;9(5):359-368. Epub 2020 Jun 19 doi: 10.1016/j.jasc.2020.06.001. PMID: 32651129
Human papillomavirus as a driver of head and neck cancers.
Sabatini ME, Chiocca S
Br J Cancer 2020 Feb;122(3):306-314. Epub 2019 Nov 11 doi: 10.1038/s41416-019-0602-7. PMID: 31708575Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Clinical prediction guides

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma.
Moore RF, Zhang XR, Allison DB, Rooper LM, Campbell AA, Eberhart CG
J Cutan Pathol 2021 Aug;48(8):1027-1033. Epub 2021 Apr 6 doi: 10.1111/cup.13987. PMID: 33745190
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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